Core Center--NIDCD Research Core Center P30

核心中心--NIDCD研究核心中心P30

• 批准号: 7901262
• 负责人: Edwin W Rubel
• 金额: $ 7.28万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-14 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7901262
• 关键词: Core; Center; NIDCD; Research; P30

DESCRIPTION (provided by applicant): This document requests renewal of the UW Research Core Center Grant that provides important infrastructure support for a large research commitment to the mission area of NIDCD. The NIDCD-funded Research Base is composed of 18 grants to 17 investigators with an annual direct cost of over $4.2 million. In addition, 10 grants and two K-awards to 8 investigators are included because they are in the mission area of NIDCD. Four Research Cores provide support for the research programs, and stimulate interactions and collaborations among investigators. Core A, the Human Subjects Recruitment Core, continues the longstanding function of recruiting and scheduling human infant subjects that meet specific criteria for studies on development of hearing and language perception. This Research Core has added services that facilitate recruitment of subjects with specific hearing and perceptual impairments. Core B, the Computer Resources Core, provides personnel with skills needed for software development for real-time physiological and behavioral investigations of auditory processing in animals and humans. Also, a systems and network manager teaches and advises investigators on optimal computer solutions. Core C, the Imaging Core, provides personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal microscopy, 3-dimensional reconstructions, and quantitative analyses of cellular attributes. This Core also supports human brain imaging initiatives. Core D, the Genetics Core, controls breeding and DMA screening for investigators using inbred and genetically manipulated mouse strains. Equipment is provided for rapid analyses of DMA sequences and for embryo preservation to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores are supported by an Administrative Core that oversees the operations of each Research Core, organizes group meetings, provides clerical, fiscal, and personnel support, and prepares reports to the funding agency.

描述（由申请人提供）：本文件请求续签华盛顿大学研究核心中心拨款，该拨款为 NIDCD 任务领域的大型研究承诺提供重要的基础设施支持。 NIDCD 资助的研究基地由向 17 名研究人员提供的 18 项资助组成，每年直接费用超过 420 万美元。此外，还包括向 8 名研究人员提供的 10 项补助金和 2 项 K 奖，因为他们属于 NIDCD 的任务区域。四个研究核心为研究项目提供支持，并促进研究人员之间的互动与合作。核心 A，即人类受试者招募核心，延续了招募和安排符合听力和语言感知发展研究特定标准的人类婴儿受试者的长期功能。该研究核心增加了有助于招募具有特定听力和知觉障碍的受试者的服务。核心 B，即计算机资源核心，为人员提供软件开发所需的技能，以对动物和人类的听觉处理进行实时生理和行为研究。此外，系统和网络管理员还向调查人员教授最佳计算机解决方案并提供建议。 Core C（成像核心）为广泛使用现代数字显微成像方法（包括共焦显微镜、3 维重建和细胞属性定量分析）的项目提供人员和设备维护。该核心还支持人脑成像计划。 Core D，即遗传学核心，使用近交和基因操纵小鼠品系为研究人员控制育种和 DMA 筛选。提供了快速分析 DMA 序列和胚胎保存的设备，以提高使用通讯障碍小鼠模型进行研究的效率。研究核心由行政核心支持，行政核心负责监督每个研究核心的运作，组织小组会议，提供文书、财务和人事支持，并为资助机构准备报告。