Core Center - NIDCD Research Core Center P30

核心中心 - NIDCD 研究核心中心 P30

• 批准号: 8526210
• 负责人: Edwin W Rubel
• 金额: $ 67.09万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8526210
• 关键词: 3-Dimensional; Animals; Area; Auditory; Behavioral; Breeding; Center Core Grants; Collaborations; Communication; Communication impairment; Computers; Confocal Microscopy; Contracts; DNA; DNA Sequence Analysis; Direct Costs; Disease; Educational process of instructing; Equilibrium; Equipment; Funding Agency; Genetic; Grant; Group Meetings; Health; Hearing; Hearing problem; Human; Human Resources; Image; Inbreeding; Infant; Investigation; K-Series Research Career Programs; Lead; Maintenance; Microscopic; Mission; Mouse Strains; National Institute on Deafness and Other Communication Disorders; Phenotype; Physiological; Prevention; Process; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Schedule; Science; Services; Solutions; System; Time; Universities; Washington; base; body system; digital; efficacy research; equilibration disorder; hearing impairment; human subject; imaging modality; improved; meetings; mouse model; operation; programs; ranpirnase; reconstruction; screening; skills; software development

DESCRIPTION (provided by applicant): The UW P30 Research Core Center Grant from NIDCD provides important infrastructure support for a large research commitment of the University of Washington to the mission areas of NIDCD. The Research Base is composed of 15 grants to 15 investigators with an annual direct cost of over $3 million. In addition, nine grants and one K-award, three R03 grants and one contract are included because they are in the mission area of NIDCD. Four Research Cores provide support for the research programs, and stimulate interactions and collaborations among investigators. Core A, the Human Subjects Recruitment Core, continues the longstanding function of recruiting and scheduling human infant subjects that meet specific criteria for studies on communication sciences and disorders. This Research Core has added services that facilitate recruitment of subjects with specific hearing impairments. Core B, the Computer Resources Core (Computer Core), provides personnel with skills needed for software development for real-time physiological and behavioral investigations of auditory processing in animals and humans. Also, a systems and network manager teaches and advises investigators on optimal computer solutions. Core C, the Imaging Core, provides personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal microscopy, 3-dimensional reconstructions, and quantitative analyses of cellular attributes. Core D, the Genetics Core, controls breeding and DNA screening for investigators using inbred and genetically manipulated mouse strains. Equipment is provided for rapid analyses of DNA sequences, and for phenotyping hearing and balance disorders to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores are supported by an Administrative Core that oversees the operations of each Research Core, organizes group meetings, provides clerical, fiscal, and personnel support, and prepares reports to the funding agency.

描述（由申请人提供）：NIDCD 提供的 UW P30 研究核心中心拨款为华盛顿大学对 NIDCD 任务领域的大型研究承诺提供重要的基础设施支持。该研究基地由向 15 名研究人员提供的 15 项资助组成，每年直接费用超过 300 万美元。此外，还包括 9 项赠款和 1 项 K 奖、3 项 R03 赠款和 1 项合同，因为它们属于 NIDCD 的任务区域。四个研究核心为研究项目提供支持，并促进研究人员之间的互动与合作。核心 A，即人类受试者招募核心，延续了招募和安排符合传播科学和障碍研究特定标准的人类婴儿受试者的长期功能。该研究核心增加了有助于招募具有特定听力障碍的受试者的服务。核心B，即计算机资源核心（Computer Core），为人员提供软件开发所需的技能，用于动物和人类听觉处理的实时生理和行为研究。此外，系统和网络管理员还向调查人员教授最佳计算机解决方案并提供建议。 Core C（成像核心）为广泛使用现代数字显微成像方法（包括共焦显微镜、3 维重建和细胞属性定量分析）的项目提供人员和设备维护。 Core D，即遗传学核心，为研究人员使用近交和基因操纵的小鼠品系控制育种和 DNA 筛选。提供了用于快速分析 DNA 序列以及对听力和平衡障碍进行表型分析的设备，以提高使用沟通障碍小鼠模型进行研究的效率。研究核心由行政核心支持，行政核心负责监督每个研究核心的运作，组织小组会议，提供文书、财务和人事支持，并为资助机构准备报告。