Mechanisms and Functional Outcomes of Excercise Progression Models in the Ederly

老年运动进展模型的机制和功能结果

基本信息

批准号：
7820459
负责人：
Jason David Allen
金额：
$ 49.95万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7820459
关键词：
Accounting Activities of Daily Living Address Aerobic Exercise Age Age Reporting Aging American American Heart Association Area Baltimore Biological Availability Biopsy Blood Vessels Blood flow Body Composition Body Regions Cardiovascular system Clinical Research Data Disabled Persons Disease Elderly Ensure Excision Exercise Exercise stress test Frequencies Health Care Costs Health Expenditures Healthcare Individual Intervention Laboratories Life Longitudinal Studies Measures Metabolic Modeling Muscle Muscle Contraction Muscle function Nitric Oxide Orthopedics Oxygen Performance Peripheral Persons Physical Function Physical activity Physiologic pulse Physiological Population Probability Protocols documentation Qualifying Reporting Risk Roentgen Rays Site Skeletal Muscle Sports Medicine Stimulus Stress Testing Training Training Programs Work college disability early onset functional outcomes human old age (65+)mortality muscle form muscular structure novel prevent response strength training success

项目摘要

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04): Clinical Research and specific Challenge Topic 04-AG-107: Mechanisms of specific benefits of different types of physical activity. MECHANISMS AND FUNCTIONAL OUTCOMES OF EXERCISE PROGRESSION MODELS IN THE ELDERLY By 2030, the number of Americans 65 years or older will account for roughly 20% of the US population, with a projected increase in the Nation's health care spending of 25%. A major factor in the projected increase in health care costs is the consequences of a progressive decline in functional capacity with advancing age. The decline in functional capacity can be slowed with the help of exercise training as recommended by the American College of Sports Medicine (ACSM) and American Heart Association (AHA). Unfortunately, improvements in functional capacity, in the elderly are rather small, in part, because many elderly cannot tolerate sufficiently high intensity exercise due to orthopedic and cardiovascular limitations. Thus, despite some success, existing training strategies, for the elderly, appear less than optimal. Therefore, the challenge for our rapidly aging nation is to define interventions, for the elderly that can slow the decline in functional capacity and performance, prevent early onset of physical disability and loss of independence. The potential impact is a reduction in the probability of disease, disability, early mortality, and health care expenditures. We hypothesize that regionally specific exercise stimuli, applied at the beginning of a training program, will serve as a physiological primer capable of removing peripheral barriers that limit functional capacity, in elderly at risk of losing independence. Removal of peripheral barriers early in a training program will unlock a greater potential for change in functional capacity. Subsequently, the objectives of this proposal are twofold: (1) To determine differences between 4 weeks of a regionally specific exercise stimulus or standard aerobic exercise training on physical and functional performance; and (2) To determine the effects of subsequent 8 weeks of progressive whole- body training protocol on the magnitude of change in physical and functional performance. Of particular importance to these objectives is the combination of physiological information from biospecimens (vascular and muscular) with functional outcomes in the elderly, following two different types of exercise training progression models. Statement of Relevance By 2030, 20% of the US population will be > 65 years old. Current training strategies for the elderly only show small effects on functional capacity. We will use a Regionally Specific Training Program to remove peripheral limitations and unlock a greater potential for change in functional capacity.

描述（由申请人提供）：本申请涉及广泛的挑战领域 (04)：临床研究和具体挑战主题 04-AG-107：不同类型身体活动的特定益处的机制。老年人锻炼进展模型的机制和功能结果到 2030 年，65 岁或以上的美国人数量将约占美国人口的 20%，预计美国医疗保健支出将增加 25%。预计医疗保健费用增加的一个主要因素是随着年龄的增长功能能力逐渐下降的后果。根据美国运动医学会 (ACSM) 和美国心脏协会 (AHA) 的建议，通过运动训练可以减缓功能能力的下降。不幸的是，老年人功能能力的改善相当小，部分原因是许多老年人由于骨科和心血管限制而无法忍受足够高强度的运动。因此，尽管取得了一些成功，但针对老年人的现有训练策略似乎不太理想。因此，我们快速老龄化的国家面临的挑战是为老年人制定干预措施，减缓功能能力和表现的下降，防止过早出现身体残疾和丧失独立能力。潜在的影响是减少疾病、残疾、早期死亡的可能性和医疗保健支出。我们假设，在训练计划开始时应用的区域特定运动刺激将作为生理学入门，能够消除限制功能能力的外围障碍，对于有失去独立风险的老年人。在训练计划的早期消除外围障碍将释放功能能力改变的更大潜力。随后，该提案的目标有两个：（1）确定 4 周的区域特定运动刺激或标准有氧运动训练对身体和功能表现的差异； (2) 确定随后 8 周渐进式全身训练方案对身体和功能表现变化幅度的影响。对于这些目标特别重要的是，遵循两种不同类型的运动训练进展模型，将生物样本（血管和肌肉）的生理信息与老年人的功能结果相结合。相关性声明到 2030 年，20% 的美国人口将> 65 岁。目前针对老年人的训练策略对功能能力的影响很小。我们将使用区域特定培训计划来消除外围限制并释放功能能力变化的更大潜力。