International Herpesvirus Workshop

国际疱疹病毒研讨会

• 批准号: 10752979
• 负责人: DANIEL N STREBLOW
• 金额: $ 0.7万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-07 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10752979
• 关键词: Acquired Immunodeficiency Syndrome; Animal Disease Models; Animals; Antiviral Agents; Atherosclerosis; Atmosphere; B-Lymphocytes; Blindness; Books; Budgets; Burkitt Lymphoma; Cells; Chickenpox; Clinical Research; Communities; Congenital Abnormality; Cytomegalovirus; DNA biosynthesis; Data; Development; Disease; Educational workshop; Encephalitis; Ensure; Enzymatic Biochemistry; Eye; Fees; Fertilization; Fostering; Funding; Gene Expression Regulation; Gene Transduction Agent; Genital; Genitalia; Genome; Grant; Health; Herpes zoster disease; Herpesviridae; Herpesviridae Infections; Herpesvirus 1; Human; Human Herpesvirus 2; Human Herpesvirus 4; Human Herpesvirus 8; Immune; Immune Evasion; Immune response; Immunology; Individual; Infection; Infectious Mononucleosis; International; Kaposi Sarcoma; Knowledge; Laboratories; Lesion; Life; Malignant Neoplasms; Medical; Membrane Proteins; Meningitis; Mental Retardation; Microbiology; Molecular; Molecular Biology; Montana; Morbidity - disease rate; Nasopharynx Carcinoma; Neoplasms; Oral; Oregon; Participant; Pathogenesis; Pathogenicity; Patients; Persons; Postdoctoral Fellow; Prevention; Publishing; Request for Proposals; Research; Research Personnel; Resistance development; Rest; Science; Scientist; Skin; Structure; Students; Talents; Training; Transcriptional Regulation; Travel; Ulcer; Underrepresented Minority; United States National Institutes of Health; Universities; Vaccination; Vaccine Therapy; Viral; Viral Vector; Virus; Work; antiviral drug development; cost; deafness; experience; gene therapy; graduate student; immunosuppressed; interdisciplinary approach; interest; meetings; mortality; opportunistic pathogen; organ transplant recipient; pathogen; patient population; post-doctoral training; posters; professor; reactivation from latency; symposium; therapeutic target; transmission process; vaccine development; virus genetics

Project Summary This proposal requests funds to be used to support travel and registration fees for postdoctoral fellows and graduate students to attend the 47th International Herpesvirus Workshop (IHW) in Missoula, Montana. The IHW is the major annual meeting for scientists studying all the herpesviruses and is very well established in its 47th year. This meeting has been very successful, in part, because of the enthusiastic participation of the world's leading herpesvirus researchers. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now- recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. In addition, CMV has been implicated as a pathogenic contributor in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosuppressed persons in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immune-compromised individuals. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.

项目概要 该提案要求资金用于支持博士后研究员的旅费和注册费以及 研究生参加在蒙大拿州米苏拉举行的第 47 届国际疱疹病毒研讨会 (IHW)。 IHW 是研究所有疱疹病毒的科学家的主要年会，已举办了 47 届 年。这次会议非常成功，部分原因在于世界各国的热情参与 领先的疱疹病毒研究人员。讲习班的力量在于相互促进 不同疱疹病毒的比较、关键问题的不同方法以及支持和支持 该领域领先研究人员的参与，最重要的是包括有前途的年轻研究人员和 学员在训练中。此外，该论坛是真正的国际性论坛，全世界都有广泛的参加者。这 现在由各种疾病引起的疾病清楚地表明了这次会议的医学重要性。 识别出八种人类疱疹病毒。这些包括皮肤和眼睛溃疡（HSV-1）、生殖器病变（HSV- 2）、脑膜炎和脑炎（HSV-1和HSV-2）、传染性单核细胞增多症（EBV）、水痘和带状疱疹 （VZV）。 CMV 是导致出生缺陷的主要原因，包括智力低下、失明和耳聋。 先天性传播，也是艾滋病患者和器官移植中重要的机会病原体 收件人。此外，CMV 被认为是疾病发展的致病因素。 动脉粥样硬化。癌症也与疱疹病毒感染有关。 EBV 与伯基特氏病有关 淋巴瘤、其他 B 细胞肿瘤和鼻咽癌。最新的人类疱疹病毒 发现（HHV-8 或 KSHV）与艾滋病患者和其他患者的卡波西肉瘤有关 其他群体中的免疫抑制者。所有疱疹病毒都会终生存在，因此构成 免疫受损个体治疗中的重大问题。重新激活引起的疾病 大多数人类疱疹病毒是各种免疫患者发病和死亡的重要原因 人口。研讨会将采用跨学科方法讨论以下主题：病毒结构、 病毒进入和细胞传播的机制、膜蛋白、发病机制和潜伏期、DNA 复制、 疫苗接种和免疫反应、转录控制、基因表达调节、化疗 靶点和病毒基因治疗。