International Herpesvirus Workshop

国际疱疹病毒研讨会

基本信息

批准号：
10057653
负责人：
JAY A NELSON
金额：
$ 1万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10057653
关键词：
Acquired Immunodeficiency Syndrome Animal Disease Models Animals Antiviral Agents Atherosclerosis Atmosphere B-Lymphocytes Berlin Blindness Books Budgets Burkitt Lymphoma Cells Chickenpox Clinical Research Communities Congenital Abnormality Cytomegalovirus DNA biosynthesis Data Development Disease Educational workshop Encephalitis Ensure Enzymatic Biochemistry Eye Fees Fertilization Fostering Funding Gene Expression Regulation Gene Transduction Agent Genital Genitalia Genome Germany Grant Health Sciences Herpes zoster disease Herpesviridae Herpesviridae Infections Herpesvirus 1 Human Human Herpesvirus 2 Human Herpesvirus 4 Human Herpesvirus 8 Immune Immune Evasion Immune response Immunology Individual Infection Infectious Mononucleosis Institutes International Kaposi Sarcoma Laboratories Lesion Life Malignant Neoplasms Medical Membrane Proteins Meningitis Mental Retardation Microbiology Molecular Molecular Biology Morbidity - disease rate Nasopharynx Carcinoma Neoplasms Oral Oregon Organ Transplantation Participant Pathogenesis Pathogenicity Patients Persons Postdoctoral Fellow Prevention Publishing Request for Proposals Research Research Personnel Resistance development Rest Scientist Skin Structure Students Talents Training Transcriptional Regulation Transplant Recipients Travel Ulcer United States National Institutes of Health Universities Vaccination Vaccine Therapy Viral Viral Drug Resistance Viral Vector Virus Work base cost deafness experience gene therapy graduate student immunosuppressed interdisciplinary approach interest meetings mortality opportunistic pathogen pathogen patient population post-doctoral training posters professor symposium transmission process vaccine development virus genetics

项目摘要

Project Summary This proposal requests funds to be used to support travel and registration fees for postdoctoral fellows and graduate students to attend the 45th International Herpesvirus Workshop (IHW) in Berlin, Germany. The IHW is the major annual meeting for scientists studying all the herpesviruses and is very well established in its 45th year. This meeting has been very successful, in part, because of the enthusiastic participation of the world’s leading herpesvirus researchers. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now- recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. In addition, CMV has been implicated as a pathogenic contributor in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt’s lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi’s sarcoma in AIDS patients and other immunosuppressed persons in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immune-compromised individuals. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.

项目概要该提案要求资金用于支持博士后研究员的旅费和注册费以及研究生参加在德国柏林举行的第 45 届国际疱疹病毒研讨会 (IHW)。研究所有疱疹病毒的科学家的重要年会，已举办了 45 届今年的会议非常成功，部分原因在于全世界的热情参与。研讨会的优势在于由顶尖疱疹病毒研究人员进行的交叉授精。不同疱疹病毒的比较、关键问题的不同方法以及支持和支持该领域领先研究人员的参与，最重要的是包括有前途的年轻研究人员和此外，该论坛是真正的国际性论坛，在世界各地都有广泛的参加者。现在由各种疾病引起的疾病清楚地表明了这次会议的医学重要性。已识别出八种人类疱疹病毒，其中包括皮肤和眼睛溃疡（HSV-1）、生殖器病变（HSV-1）。 2）、脑膜炎和脑炎（HSV-1和HSV-2）、传染性单核细胞增多症（EBV）、水痘和带状疱疹 (VZV) 是导致出生缺陷的主要原因，包括智力低下、失明和耳聋。先天性传播，也是艾滋病患者和器官移植中重要的机会病原体此外，CMV 被认为是发展中的致病因素。动脉粥样硬化也与疱疹病毒感染有关。淋巴瘤、其他 B 细胞肿瘤和鼻咽癌最新的人类疱疹病毒。发现（HHV-8 或 KSHV）与艾滋病患者和其他患者的卡波西肉瘤有关其他群体中的免疫抑制者所有的疱疹病毒都会终生存在，因此会造成感染。免疫受损个体治疗中因重新激活而引起的重大问题。大多数人类疱疹病毒是各种免疫患者发病和死亡的重要原因研讨会将采用跨学科方法讨论以下主题：病毒结构、病毒进入和细胞传播的机制、膜蛋白、发病机制和潜伏期、DNA 复制、疫苗接种和免疫反应、转录控制、基因表达调节、化疗目标和病毒基因治疗。