Administrative Core

行政核心

• 批准号: 9980277
• 负责人: JAY A NELSON
• 金额: $ 8.71万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9980277
• 关键词: Adjuvant; Binding; Communication; Complex; Contracts; Cytomegalovirus; Data; Decision Making; Development; Doctor of Philosophy; Emerging Communicable Diseases; Ensure; Environment; Fostering; Goals; Grant; Hematopoiesis; Hematopoietic stem cells; Human; Institutes; Institution; International; Lead; Maintenance; Molecular; Monitor; National Institute of Allergy and Infectious Disease; Office of Administrative Management; Pacific Northwest; Pathogenesis; Principal Investigator; Reporting; Research; Role; Signal Pathway; Signal Transduction; Time; Transplantation; United States National Institutes of Health; Viral; Virus Latency; biodefense; cell growth regulation; collaborative environment; data dissemination; data resource; data sharing; experience; meetings; member; programs

CORE C PROJECT SUMMARY The overall goal of this PPG is to elucidate the molecular mechanisms of HCMV regulation of cellular signaling in the establishment and maintenance of viral latency and viral reactivation, as well as how viral dysregulation of HSC signaling may compromise hematopoiesis. To meet this goal we have assembled an extraordinary group of virologists who will collaborate in five highly interactive projects and two scientific cores. The Program Director (PD) and Principal Investigator of the Administrative Core is Jay Nelson, Ph.D., who is a senior molecular virologist with extensive experience studying the molecular interaction of cytomegaloviruses and their host environment. Dr. Nelson will be co-leading this program with Dr. Andrew Yurochko, who is an international expert in the study of Human Cytomegalovirus dissemination and pathogenesis. They will be assisted by an exceptional administrative team that has a proven track record in administering and managing large, complex grants and contracts such as the Pacific Northwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases (PNWRCE) and a NIAID Adjuvant Discovery Contract. The significant experience of this group with the organization, reporting and communications associated with the successful administration of multi-institutional research programs will be invaluable in ensuring a successful management of this PPG. The Administrative Core will serve as a hub for administration, communication and monitoring for the entire program. The core will serve all projects and all scientific cores, and it will interact with all institutions involved in this program. The Administrative Core will also serve as a central point of interaction with NIH Program. Finally, the administrative team will assist the program director in ensuring regular and timely communication among the members of this consortium as well as reporting to NIAID Program.

核心 C 项目摘要 该 PPG 的总体目标是阐明 HCMV 调节细胞信号传导的分子机制 病毒潜伏期和病毒再激活的建立和维持，以及病毒失调如何 HSC 信号传导的减弱可能会损害造血功能。为了实现这一目标，我们组建了一支非凡的团队 病毒学家小组将在五个高度互动的项目和两个科学核心中进行合作。该计划 行政核心的主任 (PD) 和首席研究员是 Jay Nelson 博士，他是一名高级 分子病毒学家，在研究巨细胞病毒的分子相互作用和 他们的宿主环境。 Nelson 博士将与 Andrew Yurochko 博士共同领导该项目，Andrew Yurochko 博士是一名 研究人类巨细胞病毒传播和发病机制的国际专家。他们将是 由在管理和管理方面拥有良好记录的杰出管理团队协助 大型、复杂的赠款和合同，例如太平洋西北地区卓越中心 生物防御和新发传染病 (PNWRCE) 以及 NIAID 佐剂发现合同。这 该小组在组织、报告和沟通方面具有丰富的经验 多机构研究计划的成功管理对于确保研究计划的成功至关重要 该 PPG 的管理。行政核心将作为行政、沟通和管理的中心 对整个程序进行监控。该核心将服务于所有项目和所有科学核心，并且它将与 参与该计划的所有机构。行政核心也将作为互动的中心点 与美国国立卫生研究院计划。最后，行政团队将协助项目总监确保定期和 该联盟成员之间及时沟通并向 NIAID 计划报告。