Neurology of Deficient Response Control in ADHD
ADHD 反应控制缺陷的神经病学
基本信息
- 批准号:7911612
- 负责人:
- 金额:$ 59.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-15 至 2014-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdolescenceAdultAffectAnatomyAnisotropyAreaAtlasesAttention deficit hyperactivity disorderBasal GangliaBehaviorBehavioralBiologicalBrainChildChildhoodClinicalCognitiveComplexDevelopmentDiagnosisDiffusion Magnetic Resonance ImagingDiseaseDissociationFailureFamilyFinancial compensationFunctional Magnetic Resonance ImagingFunctional disorderFundingGoalsGrantImageImage AnalysisImpairmentIndividualLaboratoriesLesionMagnetic Resonance ImagingMeasuresMedialMediatingMethodsModelingMotorNeurologicNeurologyPatternPerformancePrefrontal CortexResearchSchoolsShapesShort-Term MemorySignal TransductionStimulusStructureSystemTask PerformancesTestingThickWorkbasebehavior observationbrain behavioreffective therapyendophenotypeimaging modalityimprovedinsightmorphometryneural circuitneuroimagingneuromechanismnovelpublic health relevancerelating to nervous systemresponsesocialstimulus intervaltreatment strategyvigilancewhite matter
项目摘要
DESCRIPTION (provided by applicant): Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly prevalent disorder in which impaired control of unwanted behavior affects family/social relationships and school performance. Motor response control, mediated by the basal ganglia and, at the cortical level, the supplementary motor area (SMA), is crucial for selecting to withhold unwanted responses and thereby necessary for effective inhibition of impulsive, hyperactive and off-task behavior that characterizes ADHD. Findings from the initial grant period established that ADHD is associated with abnormalities in motor response control, including impaired response inhibition and increased intrasubject response variability (ISV); additionally, the degree of impairment on these measures was found to be similar across tasks with differing cognitive demands, suggesting that impaired motor response control is a primary deficit in ADHD. Consistent with these behavioral observations, functional and anatomic MRI studies reveal children with ADHD show abnormalities in the SMA and interconnected regions of the basal ganglia. Functional MRI examination of brain-behavior correlations provided further insight, revealing that for children with ADHD, but not typically developing (TD) children, recruitment of the prefrontal cortex was associated with lower ISV, reflecting improved response control. The combined behavior and imaging findings provide the basis for a shift towards a more developmental model of ADHD in which dysfunction in neural systems critical to motor response control, established early in development, contributes to the pathophysiology of the disorder, while function of later-developing prefrontal systems facilitates compensation. The goals of the current proposal are to: use novel imaging methods to investigate the hypothesis that abnormalities in a neural circuit involving the SMA and basal ganglia contribute to ADHD-associated impairments in response control (Aim 1), investigate the hypothesis that successful motor response control in some children with ADHD depends on recruitment of prefrontal (rather than typical premotor) circuits (Aims 2 and 3), and investigate whether a presentation format that increases vigilance can also result in improved response control (Aim 4). The proposed studies will not only help to identify relevant intermediate endophenotypes of ADHD but also might point to potentially effective treatment strategies. PUBLIC HEALTH RELEVANCE: Attention Deficit Hyperactivity Disorder (ADHD) is a common disorder in childhood in which problems with response control affect social relationships and school performance. The purpose of this research is to identify differences in brain structure contributing to ADHD-associated impairments in response control and to identify mechanisms that help children with ADHD improve task performance. This work may help to improve diagnosis and treatment of ADHD.
描述(由申请人提供):注意力缺陷/多动症(ADHD)是一种非常普遍的疾病,其中对不良行为的控制受损会影响家庭/社会关系和学校表现。运动反应控制由基底神经节和皮质水平的辅助运动区 (SMA) 介导,对于选择抑制不需要的反应至关重要,因此对于有效抑制 ADHD 特征的冲动、多动和偏离任务行为是必要的。最初资助期的研究结果表明,ADHD 与运动反应控制异常有关,包括反应抑制受损和受试者内反应变异性 (ISV) 增加;此外,发现这些措施的受损程度在具有不同认知需求的任务中是相似的,这表明运动反应控制受损是 ADHD 的主要缺陷。与这些行为观察结果一致,功能性和解剖性 MRI 研究表明,患有 ADHD 的儿童的 SMA 和基底神经节互连区域存在异常。对大脑行为相关性的功能性 MRI 检查提供了进一步的见解,表明对于患有 ADHD 的儿童(但不是典型发育中的儿童)来说,前额皮质的募集与较低的 ISV 相关,反映出反应控制的改善。综合行为和影像学发现为转向 ADHD 的更发育模型提供了基础,其中对运动反应控制至关重要的神经系统功能障碍,在发育早期建立,有助于该疾病的病理生理学,而后期发育的功能前额叶系统有助于补偿。当前提案的目标是:使用新颖的成像方法来研究以下假设:涉及 SMA 和基底神经节的神经回路异常会导致 ADHD 相关的反应控制损伤(目标 1);研究成功的运动反应的假设一些患有 ADHD 的儿童的控制能力取决于前额叶(而不是典型的运动前)回路的募集(目标 2 和 3),并调查提高警惕性的呈现形式是否也能改善反应控制(目标4)。拟议的研究不仅有助于确定 ADHD 的相关中间内表型,而且还可能指出潜在有效的治疗策略。公共卫生相关性:注意力缺陷多动障碍 (ADHD) 是一种常见的儿童疾病,其中反应控制问题会影响社会关系和学校表现。这项研究的目的是确定导致多动症相关反应控制障碍的大脑结构差异,并确定帮助多动症儿童提高任务表现的机制。这项工作可能有助于改善多动症的诊断和治疗。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stewart H Mostofsky其他文献
Stewart H Mostofsky的其他文献
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{{ truncateString('Stewart H Mostofsky', 18)}}的其他基金
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism
自闭症患者的睡眠和昼夜节律障碍、大脑和神经行为发育
- 批准号:
10085599 - 财政年份:2020
- 资助金额:
$ 59.78万 - 项目类别:
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism
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10677587 - 财政年份:2020
- 资助金额:
$ 59.78万 - 项目类别:
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism
自闭症患者的睡眠和昼夜节律障碍、大脑和神经行为发育
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10450073 - 财政年份:2020
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Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism
自闭症患者的睡眠和昼夜节律障碍、大脑和神经行为发育
- 批准号:
10677587 - 财政年份:2020
- 资助金额:
$ 59.78万 - 项目类别:
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism
自闭症患者的睡眠和昼夜节律障碍、大脑和神经行为发育
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10227214 - 财政年份:2020
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Movement-Based Training for Children with ADHD: A Feasibility Study
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Neurology of Deficient Response Control in ADHD
ADHD 反应控制缺陷的神经病学
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7730783 - 财政年份:2009
- 资助金额:
$ 59.78万 - 项目类别:
Neurology of Deficient Response Control in ADHD
ADHD 反应控制缺陷的神经病学
- 批准号:
7730783 - 财政年份:2009
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$ 59.78万 - 项目类别:
Neurology of Deficient Response Control in ADHD
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8080990 - 财政年份:2009
- 资助金额:
$ 59.78万 - 项目类别:
Neurology of Deficient Response Control in ADHD
ADHD 反应控制缺陷的神经病学
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8318256 - 财政年份:2009
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