TICIPS: HIV/AIDS, Secondary Infections and Immune Modul*

TICIPS：艾滋病毒/艾滋病、继发感染和免疫模块*

• 批准号: 7939040
• 负责人: William Robert Folk
• 金额: $ 15万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7939040
• 关键词: Adult; Affect; African; African Traditional Medicine; Anti-Inflammatory Agents; Anti-inflammatory; CD4 Positive T Lymphocytes; Cytokine Network Pathway; Data; Disease Progression; HIV; HIV-1; Health Surveys; Immune; In Vitro; Indigenous; Individual; Infection; Inflammatory; Lymphocyte Count; Malignant Neoplasms; Measures; Medical; Outcome Study; Phytotherapy; Plants; Property; Quality of life; Safety; Surveys; Viral; Viral Load result; Virus Diseases; immune function; microbial; randomized placebo controlled trial; secondary infection; stress related disorder; wasting

DESCRIPTION (provided by applicant): An estimated 4.69 million South Africans are infected with Type 1 human immunodeficiency virus (HIV). HIV infection in incurable and, if untreated, is ultimately fatal in approximately 95% of infected individuals. L frutescens is thought to be among the most efficacious plants used in southern African traditional medicine. The plant has been used in indigenous settings to treat serious microbial infections, especially HIV infection, as well as cancer and inflammatory conditions. Beneficial effects have also been observed in wasting conditions and stress-related disorders. It is possible that L frutescens may have useful effects in HIV infected adults. Early HIV infection has been associated with a significant reduction in quality of life in multiracial South Africans measured by the Medical Outcomes Study HIV Health Survey (MOS-HIV) instrument. The observed anti-inflammatory properties of L. frutescens may favourably influence cytokine networks with beneficial effects on quality of life, viral replication and immune functioning. It is essential to document that this widely used phytotherapy can be used safely in HIV-infected adults, and to attempt to demonstrate potentially beneficial affects. Recent data has demonstrated that there are significant in vitro interactions between Sutherlandia and antiretrovirals commonly used to treat HIV infection. We propose a 4- year randomized placebo controlled trial of Lesssertia frutescens in order to determine this plant species safety and effects on quality of life and markers of HIV disease progression. Specific Aim 1: To determine the safety of Lessertia frutescens used by HIV-1 infected adults. Specific Aim 2: To determine the effect of Lessertia frutescens on quality of life in HIV-infected adults measured by the Medical Outcomes Study HIV Health Survey (MOS-HIV). Specific Aim 3: To assess the influence of Lessertia frutescens on CD4 T-lymphocyte count in HIVinfected adults. Specific Aim 4: To evaluate the impact of Lessertia frutescens on HIV viral load in HIV-infected adults.

描述（由申请人提供）：估计有 469 万南非人感染 1 型人类免疫缺陷病毒 (HIV)。 HIV 感染无法治愈，如果不治疗，大约 95% 的感染者最终会死亡。 L frutescens 被认为是南部非洲传统医学中使用的最有效的植物之一。该植物已在当地环境中用于治疗严重的微生物感染，尤其是艾滋病毒感染，以及癌症和炎症性疾病。在消耗性疾病和压力相关疾病中也观察到了有益效果。果乳杆菌可能对感染艾滋病毒的成年人产生有益的作用。根据医疗结果研究艾滋病毒健康调查 (MOS-HIV) 仪器的测量，早期艾滋病毒感染与多种族南非人的生活质量显着下降有关。观察到的果乳杆菌的抗炎特性可能会对细胞因子网络产生有利影响，对生活质量、病毒复制和免疫功能产生有益影响。必须证明这种广泛使用的植物疗法可以安全地用于感染艾滋病毒的成年人，并尝试证明潜在的有益影响。最近的数据表明，Sutherlandia 与常用于治疗 HIV 感染的抗逆转录病毒药物之间存在显着的体外相互作用。我们提议对 Lesssertia frutescens 进行一项为期 4 年的随机安慰剂对照试验，以确定该植物物种的安全性以及对生活质量和 HIV 疾病进展标志物的影响。 具体目标 1：确定 HIV-1 感染成人使用Lessertia frutescens 的安全性。 具体目标 2：确定Lessertia frutescens 对通过医疗结果研究 HIV 健康调查 (MOS-HIV) 测量的 HIV 感染成人的生活质量的影响。 具体目标 3：评估Lessertia frutescens 对 HIV 感染成人的 CD4 T 淋巴细胞计数的影响。 具体目标 4：评估Lessertia frutescens 对 HIV 感染成人的 HIV 病毒载量的影响。