Influence of physical activity on leptin receptor expression in adult women

体力活动对成年女性瘦素受体表达的影响

基本信息

批准号：
7844928
负责人：
JOSEPH G CANNON
金额：
$ 18.38万
依托单位：
AUGUSTA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7844928
关键词：
21 year old Adipocytes Adipose tissue Adult Aerobic Aerobic Exercise Affect Animals Atherosclerosis Belief Biological Markers Blood Blood Pressure Blood Vessels Blood flow Body Weight Body Weight Changes Body Weight decreased Body fat CD14 gene Caliber Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Cell Adhesion Molecules Cell Culture Techniques Cell surface Cells Chronic Communication Coronary heart disease Eating Energy Metabolism Environmental Risk Factor Exercise FCGR3B gene Fatty acid glycerol esters Flow Cytometry Foundations Genetic Goals Health Health Benefit Health behavior Heart Diseases Hormones Human Hypertension Hypotension Hypothalamic structure Immune system In Vitro Incentives Individual Intention Intervention Knowledge Leptin Link Measures Mediating Metabolic Diseases Methods Monitor Mononuclear Obesity Outcome Overweight Pathogenesis Patients Persons Phenotype Physical activity Physiological Play Prevalence Preventive Procedures Production Proteins Role Societies Stroke Testing Therapeutic Thick Training Vascular remodeling Weight Weight maintenance regimen Woman base cardiovascular disorder risk cytokine experience in vivo intima media leptin receptor monocyte mortality novel older women prevent public health relevance receptor expression response sedentary treatment program weight maintenance

项目摘要

DESCRIPTION (provided by applicant): The prevalence of hypertension and cardiovascular disease has increased in recent decades in parallel with increasing obesity. This project explores the hypothesis that a person's physical activity levels influence expression of receptors for leptin, a hormone produced primarily by adipose tissue that increases blood pressure. Leptin also modifies the function of monocytes, cells that play a central role in the pathogenesis of atherosclerosis. Healthy subjects between the ages of 21 and 40 will be assessed for body fat, habitual physical activity levels, aerobic capacity, cardiovascular function, and monocyte leptin receptor expression. The goals of this project are to (a) identify and validate a biomarker (leptin receptor expression on monocytes) that may provide a novel method for determining cardiovascular disease risk and for monitoring the response to exercise intervention; and (b) to determine how leptin affects monocyte function. If physical activity is shown to reduce leptin receptor expression, thus breaking a critical link between fatness and cardiovascular disease, such information can be used as incentive in exercise-based preventive and treatment programs. Less emphasis could be placed on weight loss itself, which is so difficult to attain or maintain, and more emphasis could be placed on the health benefits of exercise, regardless of weight outcomes. PUBLIC HEALTH RELEVANCE: Being overweight puts an individual at greater risk of cardiovascular disease. This project will investigate how fat cells communicate with cells of the immune system to cause high blood pressure and atherosclerosis, and how physical activity disrupts this unhealthy communication.

描述（由申请人提供）：近几十年来，高血压和心血管疾病的患病率随着肥胖的增加而增加。该项目探讨了这样的假设：一个人的体力活动水平会影响瘦素受体的表达，瘦素是一种主要由脂肪组织产生的激素，会增加血压。瘦素还可以改变单核细胞的功能，这些细胞在动脉粥样硬化的发病机制中发挥着核心作用。将评估 21 岁至 40 岁之间的健康受试者的体脂、习惯性体力活动水平、有氧能力、心血管功能和单核细胞瘦素受体表达。该项目的目标是 (a) 识别和验证生物标志物（单核细胞上的瘦素受体表达），该标志物可能为确定心血管疾病风险和监测对运动干预的反应提供一种新方法； (b) 确定瘦素如何影响单核细胞功能。如果身体活动被证明可以减少瘦素受体的表达，从而打破肥胖和心血管疾病之间的关键联系，那么这些信息可以用作基于运动的预防和治疗计划的激励。可以少强调减肥本身，因为减肥很难实现或维持，而可以更多地强调运动对健康的益处，而不管体重结果如何。公共卫生相关性：超重会使个人患心血管疾病的风险更大。该项目将研究脂肪细胞如何与免疫系统细胞进行通讯以导致高血压和动脉粥样硬化，以及体力活动如何破坏这种不健康的通讯。