Integrated Membrane Program (IMP)

综合膜计划（IMP）

基本信息

批准号：
10618904
负责人：
Todd B Reynolds
金额：
$ 31.83万
依托单位：
UNIVERSITY OF TENNESSEE KNOXVILLE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10618904
关键词：
Membrane programs

项目摘要

Project Summary The Integrated Membrane Program (IMP) T32 Training Grant will address an important gap that exists in the biomedical workforce of the future. The IMP will address research training needs in the area of biological membranes (biomembranes), which are crucially important structures that define and separate physical spaces within and outside cells, making them fundamental to life on Earth. However, biomembranes do much more, as they control intracellular signaling and development, are required for energy production, mediate drug delivery and drug resistance, are essential for making essential cellular macromolecules, and affect growth and movement, which impacts cancer and other diseases. Thus, understanding biomembranes impacts many critical areas of biomedical research. Biomembranes research as a field covers the mechanisms by which membranes are synthesized from their constituent proteins, lipids, and carbohydrates, are trafficked and changed in response to the environment, and then in turn affect the many processes described above. Additionally, human manipulation of natural and synthetic membranes can be harnessed for myriad applications from computation to energy production to the development of new materials. Multiple fields and disciplines including biology, physics, chemistry, engineering, and computational science have applicability to biomembranes, but increasingly, there is a need for scientists who can bridge these fields and integrate different approaches to meet the next generation of research challenges. The University of Tennessee, Knoxville (UT) has unique breadth and depth in biomembrane research, with federally funded, collaborative researchers spanning 7 departments in 4 colleges. The 32 faculty in the IMP mentor pool have a shared commitment to establish a training program that will span fields and disciplines. These scientists are already working together through the establishment of the UT- facilitated Community of Scholars (COS) for Biomembranes, which has met 2-3 times every semester since 2018, and where many students have presented seminars on their research. The shared research, training, and overall momentum that exists within the Biomembranes COS forms the foundation for the IMP T32. Multiple investigators within the Biomembranes COS have ongoing collaborations that span fields and disciplines, and have co-mentored graduate students. The establishment of a T32-based IMP will formalize this integrated approach to training so these students can advance fundamental knowledge of biomembranes and apply this knowledge to improve human health. In addition to integrated training in science, the IMP will further enhance training in responsible conduct of research, reproducibility, and diversity and inclusion, which are already being addressed at UT, but will be formalized under this NIH T32 mechanism.

项目概要综合膜计划 (IMP) T32 培训补助金将解决现有技术中存在的重要差距未来的生物医学劳动力。 IMP 将满足生物领域的研究培训需求膜（生物膜），是定义和分隔物理空间的至关重要的结构细胞内外，使它们成为地球生命的基础。然而，生物膜的作用远不止于此，它们控制细胞内信号传导和发育，是能量产生、介导药物输送所必需的和耐药性，对于制造必需的细胞大分子至关重要，并影响生长和运动会影响癌症和其他疾病。因此，了解生物膜影响许多关键生物医学研究领域。生物膜研究作为一个领域涵盖了膜的机制由其组成蛋白、脂质和碳水化合物合成，被运输和响应而改变环境，然后反过来影响上述许多过程。此外，人类天然和合成膜的操纵可用于从计算到计算的无数应用从能源生产到新材料的开发。多个领域和学科，包括生物学、物理学、化学、工程学和计算科学都适用于生物膜，但越来越多地需要科学家能够弥合这些领域并整合不同的方法来满足下一代的需求研究挑战。田纳西大学诺克斯维尔分校（UT）在以下领域拥有独特的广度和深度：生物膜研究，由联邦政府资助，合作研究人员横跨 4 个学院的 7 个系。 IMP 导师库中的 32 名教员共同致力于建立一个培训计划，该计划将涵盖领域和学科。这些科学家已经通过建立 UT- 促进了生物膜学者社区 (COS)，自此以来每学期举行 2-3 次会议 2018 年，许多学生就他们的研究举办了研讨会。共同的研究、培训和生物膜 COS 中存在的整体动力构成了 IMP T32 的基础。多种的生物膜 COS 内的研究人员正在进行跨领域和学科的合作，并且共同指导研究生。基于 T32 的 IMP 的建立将使这种集成正式化培训方法，使这些学生能够提高生物膜的基础知识并应用它改善人类健康的知识。除了科学方面的综合培训外，IMP还将进一步加强负责任的研究行为、可重复性以及多样性和包容性方面的培训，这些培训已经在在 UT 中解决，但将在 NIH T32 机制下正式化。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Challenges and the Evolving Landscape of Assessing Blood-Based PD-L1 Expression as a Biomarker for Anti-PD-(L)1 Immunotherapy.

评估基于血液的 PD-L1 表达作为抗 PD-(L)1 免疫疗法的生物标志物的挑战和不断发展的前景。

DOI：
发表时间：
2022-05-20
期刊：
影响因子：
4.7
作者：
Wang, Tao;Denman, Desirée;Bacot, Silvia M;Feldman, Gerald M
通讯作者：
Feldman, Gerald M

Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury.

人参中的人参皂苷 Rc 可改善棕榈酸酯引起的 UB/OC-2 耳蜗细胞损伤。

DOI：
发表时间：
2023-04-16
期刊：
影响因子：
5.6
作者：
Gill, Nicholas B;Dowker;Hubbard, Katelin;Voy, Brynn H;Whelan, Jay;Hedrick, Mark;Bettaieb, Ahmed
通讯作者：
Bettaieb, Ahmed

Complete Genome Sequence of Pseudomonas sp. Strain 273, a Haloalkane-Degrading Bacterium.

假单胞菌属的完整基因组序列。

DOI：
发表时间：
2023-07-18
期刊：
影响因子：
0.8
作者：
Xie, Yongchao;Chen, Gao;Ramirez, Diana;Yan, Jun;Löffler, Frank E
通讯作者：
Löffler, Frank E

PEGylated nanoparticles interact with macrophages independently of immune response factors and trigger a non-phagocytic, low-inflammatory response.

聚乙二醇化纳米粒子与巨噬细胞相互作用，独立于免疫反应因子，并引发非吞噬性、低炎症反应。

DOI：
发表时间：
2024-02
期刊：
影响因子：
0
作者：
Asoudeh, Monireh;Nguyen, Nicole;Raith, Mitch;Denman, Desiree S;Anozie, Uche C;Mokhtarnejad, Mahshid;Khomami, Bamin;Skotty, Kaitlyn M;Isaac, Sami;Gebhart, Taylor;Vaigneur, Lauren;Gelgie, Aga;Dego, Oudessa Kerro;Freeman, Trevor;Beever, Jon;Da
通讯作者：
Da

MCMV Centrifugal Enhancement: A New Spin on an Old Topic.

MCMV 离心增强：老话题的新旋转。