Neuroimmunology of Disease Training Program

疾病神经免疫学培训计划

基本信息

批准号：
10875267
负责人：
Howard E Gendelman
金额：
$ 0.18万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10875267
关键词：
Disease Training Programs neuroimmunology

项目摘要

ABSTRACT Despite advances in basic and translational neuroscience research, effective therapeutics for neurodegenerative, neuroinflammatory, psychiatric, developmental, and neuroinfectious disorders remain in want. The National Institutes of Health has recognized bench to bedside research to improve disease outcomes and as such initiated programs to train researchers who can conceptualize new disease approaches to aide in effective treatments for neurological disease. One critical “in need” area is neuroimmunity which remains understudied despite its close linkage to the pathobiology of a broad spectrum of neurological disorders. The tradition of training separate groups of students in the disciplines of neuroscience and immunology hinders field growth. Following notable training successes, we seek continuance in training of predoctoral students in studies of neuroimmunology with linkages to neuronal injury, differentiation, regeneration, and protection. The program is designed to train 4 predoctoral students at a time in 1 or 2 year appointments with broad exposures to research methods facilitating best approach, technical, and outcome proficiency. And that each student acquires a broad interdisciplinary field knowledge. This allows for critical thinking in how inflammation affects disease pathogenesis and treatment. Several approaches are proposed to achieve these goals. First, is providing students training opportunities for multidisciplinary studies that intersect immunity and neural function. Second, is the use of our textbook Neuroimmune Pharmacology designed specifically as a guide in the intersections between neuroscience, immunology, and pharmacology. This is taught in our Neuroimmunology course. Third, we will provide a unique conceptual framework to integrate approaches relevant to neuroimmunology research. This contains, but is not limited to, systems biology, cell signaling, glial and neuronal biology, relevant rodent and laboratory models, and synaptic-network physiology. Fourth, are our bi-monthly workshops with student presentations to the program’s neuroscience and immunology faculty and a statistician to acquire feedback in research design, uses and limits of quantitative approaches, statistical interpretations, and conceptualization of ongoing research activities. These are highly interactive, diving into the mechanics of research and complement the formal student research presentations at the program’s annual retreat. Fifth, are clinical neurological experiences to gain the big-picture of a real-world perspective of neurological disease. Sixth, are “cross- disciplinary internships” where students will complete thesis component(s) in another laboratory using a different research approach and mentor. Seventh, are sustained community, university, and logistical support. By coordinating the training efforts of divergent research groups linked by common interests in neuroimmunity, trainees will develop deeper understandings of innate and adaptive immunity in relationship to neurologic disease. Such trainees will be better prepared to develop successful careers in studies of disease pathobiology and therapeutic interventions for human nervous system disorders.

抽象的尽管基础和转化神经科学研究取得了进展，但有效的治疗方法神经退行性、神经炎症、精神、发育和神经感染性疾病仍然存在美国国立卫生研究院已认可临床研究以改善疾病结果。因此启动了培训研究人员的计划，他们可以概念化新的疾病方法来帮助神经系统疾病的有效治疗方法之一仍然是神经免疫。尽管它与广泛的神经系统疾病的病理学密切相关，但尚未得到充分研究。在神经科学和免疫学学科中对不同学生群体进行培训的传统阻碍了该领域的发展在取得显着的培训成功之后，我们寻求继续对博士生进行研究培训。神经免疫学与神经损伤、分化、再生和保护的联系。旨在在 1 或 2 年的任命中一次培训 4 名博士前学生，让他们广泛接触研究促进最佳方法、技术和结果熟练程度的方法，并且每个学生都能获得广泛的知识。这允许对炎症如何影响疾病进行批判性思考。提出了几种实现这些目标的方法。其次，学生有机会进行免疫和神经功能交叉的多学科研究。是使用我们专门设计的教科书《神经免疫药理学》作为交叉点的指南第三，神经科学、免疫学和药理学之间的关系。我们将提供一个独特的概念框架来整合与神经免疫学研究相关的方法。这包含但不限于系统生物学、细胞信号传导、神经胶质和神经元生物学、相关啮齿动物第四，是我们与学生举办的双月研讨会。向该项目的神经科学和免疫学教师以及统计学家进行演示，以获取反馈研究设计、定量方法的使用和限制、统计解释以及概念化这些活动具有高度互动性，深入研究研究机制并进行补充。第五，该项目年度静修会上的正式学生研究报告是临床神经学研究。第六，获得神经系统疾病真实世界视角的经验。学科实习”，学生将使用不同的实验室在另一个实验室完成论文部分第七，持续的社区、大学和后勤支持。协调因神经免疫方面的共同兴趣而联系在一起的不同研究小组的培训工作，学员将对与神经系统相关的先天性和适应性免疫有更深入的了解这些学员将为在疾病病理学研究领域发展成功的职业生涯做好更好的准备。以及人类神经系统疾病的治疗干预。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Brain changes in a maternal immune activation model of neurodevelopmental brain disorders.

神经发育脑疾病的母体免疫激活模型中的大脑变化。

DOI：
发表时间：
2019
期刊：
影响因子：
6.7
作者：
Bergdolt, Lara;Dunaevsky, Anna
通讯作者：
Dunaevsky, Anna

Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies.

细胞外囊泡在药物滥用和 HIV 相关神经病理学中的作用。

DOI：
发表时间：
2020-09-15
期刊：
影响因子：
5.6
作者：
Odegaard, Katherine E;Chand, Subhash;Wheeler, Sydney;Tiwari, Sneham;Flores, Adrian;Hernandez, Jordan;Savine, Mason;Gowen, Austin;Pendyala, Gurudutt;Yelamanchili, Sowmya V
通讯作者：
Yelamanchili, Sowmya V

Lactic acid bacterial surface display of scytovirin inhibitors for anti-ebolavirus infection.

乳酸菌表面展示细胞病毒素抑制剂，用于抗埃博拉病毒感染。

DOI：
发表时间：
2023
期刊：
影响因子：
0
作者：
Wiggins, Joshua;Nguyen, Ngan;Wei, Wenzhong;Wang, Leah Liu;Hollingsead Olson, Haley;Xiang, Shi
通讯作者：
Xiang, Shi

Multielectrode Transcranial Electrical Stimulation of the Left and Right Prefrontal Cortices Differentially Impacts Verbal Working Memory Neural Circuitry.

左右前额皮质的多电极经颅电刺激对言语工作记忆神经回路有不同的影响。

DOI：
10.1093/cercor/bhz246
发表时间：
2019-12-04
期刊：
Cerebral cortex
影响因子：
3.7
作者：
Sam M. Koshy;Alex I. Wiesman;Rachel K. Spooner;C. Embury;Michael T. Rezich;E. Heinrichs;T. Wilson
通讯作者：
T. Wilson

Peripheral inflammation is strongly linked to elevated zero maze behavior in repeated social defeat stress.

周围炎症与反复社交失败压力下零迷宫行为的升高密切相关。