Neuroimmunology of Disease Training Program

疾病神经免疫学培训计划

• 批准号: 10200159
• 负责人: Howard E Gendelman
• 金额: $ 18.99万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200159
• 关键词: Disease; Training Programs; neuroimmunology

ABSTRACT Despite advances in basic and translational neuroscience research, the development of new therapeutics remains in want. The National Institutes of Health has recognized the need to translate bench research to therapies that improve human disease outcomes and initiated programs that train researchers who can effectively conceptualize neurological disease processes. One critical “in need” area is in the discipline of neuroimmunity. This research area remains understudied despite its close linkage to the pathobiology of degenerative, infectious, developmental, and psychiatric disorders. To these ends, our training goal is to provide talented students with a fundamental understanding of peripheral and central immunology as it affects neuronal injury, differentiation, regeneration, and protection. The program is designed to provide the student with broad exposure to research methods that facilitate technical proficiency. The program ensures that the student will acquire broad knowledge in neuroimmunity. This would allow critical thinking for how inflammation affects the pathogenesis and treatment of neurological disorders. Several approaches are proposed to achieve this goal. First, is the use of our newly published textbook Neuroimmune Pharmacology (2nd Ed.) designed specifically as a coursework guide in neuroscience, immunology, and pharmacology. Second, is in developing a cross discipline mentorship training to provide the student with opportunities to intersect studies of immunity and neural function. Third, are “unique” research experiences in systems biology, cell signaling, glial and neuronal biology, human disease models and synaptic physiology. These opportunities serve to complement research in neural genetics, development, repair, and pharmacology. Fourth, are formal student presentations to interdisciplinary basic neuroscientists and supervisory committees to acquire research feedback in design, interpretation and conceptualization of ongoing research activities. This serves to challenge existing paradigms and existing student perceptions. Fifth, are uniquely offered cross-discipline team mentoring, teaching, and clinical neurological experiences. Sixth, are cross-disciplinary internships where students will complete thesis component(s) in another laboratory using a different research approach and mentor. Seventh, are sustained community, university and logistical support. By coordinating the training efforts of divergent research groups linked by common interests in neuroimmunity trainees will develop deeper understandings of innate and adaptive immunity in relationship to neurologic disease. Such trainees will be better prepared to develop successful careers in studies of disease pathobiology and therapeutic interventions for human nervous system disorders.

抽象的 尽管基础和转化神经科学研究取得了进展，但新疗法的开发 美国国立卫生研究院已经认识到需要将实验室研究成果转化为技术。 改善人类疾病结果的疗法，并启动了培训研究人员的计划 从概念上讲，一个关键的“有需要”的领域是有效地治疗神经系统疾病的过程。 尽管该研究领域与病理学密切相关，但其研究仍然不足。 为此，我们的培训目标是： 为有才华的学生提供对外周和中枢免疫学的基本了解，因为它影响 该计划旨在为学生提供神经损伤、分化、再生和保护。 广泛接触促进技术熟练程度的研究方法。 学生将获得神经免疫方面的广泛知识，这将使我们能够批判性地思考炎症是如何发生的。 提出了几种方法来实现神经系统疾病的发病机制和治疗。 这个目标首先是利用我们新出版的教材《神经免疫药理学》（第二版）设计的。 其次，正在开发神经科学、免疫学和药理学的课程指南。 跨学科指导培训，为学生提供免疫交叉研究的机会 第三，在系统生物学、细胞信号传导、神经胶质细胞和神经功能方面有“独特”的研究经验。 这些机会可以作为神经生物学、人类疾病模型和突触生理学的补充。 第四，神经遗传学、发育、修复和药理学的研究，是正式的学生演讲。 跨学科的基础神经科学家和监督委员会以获得设计方面的研究反馈， 对正在进行的研究活动的解释和概念化有助于挑战现有的范式。 第五，提供独特的跨学科团队指导、教学和培训。 第六，临床神经学经验是跨学科实习，学生将在其中完成论文。 第七，另一个实验室使用不同的研究方法和导师。 社区、大学和后勤支持 通过协调不同研究小组的培训工作。 通过神经免疫受训者的共同兴趣联系在一起，将对先天和 这些受训者将为发展与神经系统疾病相关的适应性免疫做好更好的准备。 在人类神经系统疾病病理学和治疗干预研究方面取得成功 失调。