Year 2, Targeted and Clinical Assay Supplement to the NPH MCAC

第 2 年，NPH MCAC 的靶向和临床检测补充

• 批准号: 10867046
• 负责人: SUSAN J SUMNER
• 金额: $ 120万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10867046
• 关键词: Aldosterone; Amino Acids; Biogenic Amines; Biological; Biological Assay; Biological Markers; Branched-Chain Amino Acids; Clinical; Diet; Dietary Practices; Dietary intake; Enrollment; Food Patterns; Goals; Health; Individual; Learning; Link; Liquid substance; Measurement; Persons; Phenotype; Phytochemical; Precision Health; Regulation; Renin; Sex Hormone-Binding Globulin; acylcarnitine; cardiovascular health; individual response; metabolomics; precision nutrition; prediction algorithm; response; tool

Abstract The Nutrition for Precision Health (NPH) study will enroll over 10,000 people to learn more about individuals’ dietary patterns, and their responses to dietary intake. The overall goal of the NPH study is to develop algorithms that predict individual responses to food and dietary patterns. To facilitate the NPH study goal, the NPH Metabolomics and Clinical Assay Center (MCAC) will conduct a range of NPH consortium prioritized clinical assays, targeted and untargeted metabolomics assays, and phytochemical assays using biospecimens collected from people while on their habitual diets, prior to and following each of 3 NPH diets, and following liquid meal and diet specific meal challenges. This supplement is prepared to add additional biomarker assays that will aid in linking the relationship between dietary intake and health. 1

抽象的 精准健康营养 (NPH) 研究将招募超过 10,000 人，以更多地了解个人的健康状况 NPH 研究的总体目标是制定饮食模式及其对饮食摄入的反应。 预测个体对食物和饮食模式的反应的算法 为了促进 NPH 研究目标， NPH 代谢组学和临床检测中心 (MCAC) 将开展一系列 NPH 联盟优先工作 临床检测、靶向和非靶向代谢组学检测以及使用检测的植物化学检测 生物样本是在人们习惯饮食时、在 3 种 NPH 饮食之前和之后收集的， 以及在液体餐和饮食特定膳食挑战之后，该补充剂可添加额外的营养。 生物标志物测定有助于将饮食摄入与健康之间的关系联系起来。 1

项目成果

Transforming Big Data into AI‐ready data for nutrition and obesity research

• DOI: 10.1002/oby.23989
• 发表时间: 2024-03-01
• 期刊: Obesity
• 影响因子: 6.9
• 作者: Diana M Thomas;Rob Knight;Jack A Gilbert;M. Cornelis;Marie G Gantz;Kate Burdekin;Kevin Cummiskey
• 通讯作者: Kevin Cummiskey

Concordance of Chronic Kidney Disease Stage and Metformin Management Using CKD-EPI 2021 Race-Free Equation vs CKD-EPI 2009 Equation to Estimate Glomerular Filtration Rate.

使用 CKD-EPI 2021 无种族方程与 CKD-EPI 2009 方程估算肾小球滤过率的慢性肾病分期和二甲双胍管理的一致性。

• 发表时间: 2023-02-01
• 影响因子: 9.3
• 作者: Maynard, Robert D;Korpi;Cotten, Steven W
• 通讯作者: Cotten, Steven W

Psychedelics for Medicinal Use: How Will This Alter the Collective Laboratory Consciousness?

药用迷幻药：这将如何改变集体实验室意识？

• 发表时间: 2023-04-03
• 影响因子: 9.3
• 作者: Cotten, Steven W;Strathmann, Frederick G;Barrett, Frederick S;Labay, Laura;Mullally, James;Sherwood, Alexander M;Wiegand, Frank
• 通讯作者: Wiegand, Frank