Midcareer Investigator Award in Patient-Oriented Research: Yael Schenker, MD, MAS

以患者为导向的研究中的职业生涯中期研究员奖：Yael Schenker，医学博士，MAS

• 批准号: 10592288
• 负责人: Yael Schenker
• 金额: $ 18.46万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592288
• 关键词: Address; Adult; Advanced Malignant Neoplasm; Age; Aging; Attention; Award; Behavior Therapy; Caregiver Burden; Caregivers; Caring; Chronic; Clinical; Clinical Investigator; Cognition; Collaborations; Communication; Compassion; Computerized Medical Record; Data; Data Set; Dedications; Diagnosis; Discipline; Disease; Educational Curriculum; Elderly; Enrollment; Environment; Faculty; Family Caregiver; Fostering; Foundations; Funding; Future; Geriatric Assessment; Geriatrics; Goals; Grant; Infrastructure; Intervention; Intervention Studies; Intervention Trial; Investigation; Learning; Malignant Neoplasms; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modeling; Morbidity - disease rate; Office Nursing; Older Population; Oncology; Outcome; Palliative Care; Patients; Personal Satisfaction; Policies; Population; Positioning Attribute; Postdoctoral Fellow; Pragmatic clinical trial; Public Health; Quality of Care; Quality of life; Reporting; Research; Research Personnel; Research Training; Resources; Role; Social support; Students; Techniques; Testing; Thinking; Time; Training; Universities; Update; Visit; Work; age related; care delivery; care seeking; career; career development; design; experience; improved; improved outcome; innovation; longitudinal dataset; medical specialties; mindfulness; next generation; novel; older patient; outreach; palliative; preference; professor; programs; resilience; skills; student mentoring; therapy design; therapy development; trial design

ABSTRACT: The growing population of older adults with advanced cancer experiences significant public health problems, including steep declines in quality of life, receipt of care that does not reflect patients' values and preferences, and high rates of caregiver burden. Inadequate attention to patient priorities and age-related concerns (e.g., function, cognition, and social support)—contribute to morbidity in this population. The emerging field of geriatric palliative care seeks to address age-related concerns and align care with patient goals over the trajectory of chronic and serious illness. The overarching goal of this K24 proposal is to enhance the candidate's mentorship of students, fellows, and junior faculty pursuing geriatric palliative care research, with a particular focus on identifying unmet geriatric palliative care needs and developing and testing interventions to improve quality of life and goal-concordant care for older patients with advanced cancer. As a successful mid-career investigator with a track record of leading successful palliative intervention trials with seriously ill older patients, the candidate is well-positioned to mentor the next generation of aging researchers. This award will leverage an outstanding longitudinal dataset of over 400 audio-recorded `primary' palliative care visits with older patients with advanced cancer and longitudinal patient- and caregiver-reported outcomes to explore optimal geriatric palliative care intervention designs. The research aims are to (1) characterize communication about age-related concerns in primary palliative care visits with older adults with advanced cancer and their family caregivers; (2) identify missed opportunities for addressing age- related concerns in primary palliative care visits for older adults with advanced cancer and their family caregivers; and (3) refine a conceptual model for primary palliative care delivery that incorporates age- related concerns and can be optimized to improve quality of life for older adults with advanced cancer. The K24 award will provide protected time for the candidate to update and expand her mentorship program, building bridges between researchers in geriatrics, palliative care and oncology. She will leverage outstanding aging research and mentoring resources available at the University of Pittsburgh; learn new skills to foster inquiry, wellbeing and resilience among trainees; and create a Junior Faculty Visiting Professor Program for geriatric palliative care researchers. This proposal is significant and innovative because it will support new clinical investigators using novel mentoring techniques and develop pilot data to inform large-scale trials addressing deficiencies in quality of care for a burgeoning population of older adults with advanced cancer. It is highly feasible because the candidate is a committed mentor with ongoing R01 funding, from an outstanding research environment with strong geriatrics programs and a large pool of potential mentees.

摘要：患有晚期癌症的老年人口数量不断增加，其影响显着 公共卫生问题，包括生活质量急剧下降、接受的护理没有反映 患者的价值观和偏好，以及护理人员的高负担率。 优先事项和与年龄相关的问题（例如功能、认知和社会支持）——有助于 老年姑息治疗这一新兴领域致力于解决与年龄相关的问题。 关注慢性病和严重疾病的发展轨迹，并使护理与患者目标保持一致。 该 K24 提案的总体目标是加强候选人对学生、研究员、 和初级教师从事老年姑息治疗研究，特别关注确定未满足的问题 老年姑息治疗需求以及开发和测试干预措施以改善生活质量和 作为一名成功的职业生涯中期研究者，为患有晚期癌症的老年患者提供目标一致的护理。 拥有对重病老年患者进行领先成功的姑息干预试验的记录， 候选人有能力指导下一代老龄研究人员。 利用包含 400 多次录音“初级”姑息治疗就诊的出色纵向数据集 患有晚期癌症的老年患者以及患者和护理人员纵向报告的结果 探索最佳的老年姑息治疗干预设计。研究目的是 (1) 表征。 在初级姑息治疗就诊时与患有以下疾病的老年人就与年龄相关的问题进行沟通 晚期癌症及其家庭护理人员；(2) 找出错失的解决年龄问题的机会； 患有晚期癌症的老年人及其家人在初级姑息治疗就诊中的相关问题 (3) 完善初级姑息治疗的概念模型，其中纳入了年龄因素 相关问题，并且可以进行优化以改善患有晚期癌症的老年人的生活质量。 K24 奖项将为候选人提供受保护的时间来更新和扩展她的指导 她将在老年病学、姑息治疗和肿瘤学研究人员之间架起桥梁。 利用匹兹堡大学优秀的老龄化研究和指导资源； 学习新技能，培养学员的探究精神、幸福感和适应力，并创建一支初级教师队伍； 老年姑息治疗研究人员客座教授计划这一提案意义重大。 创新，因为它将支持新的临床研究人员使用新颖的指导技术和 开发试点数据，为大规模试验提供信息，解决新兴市场护理质量的缺陷 患有晚期癌症的老年人群是高度可行的，因为候选人是 坚定的导师，拥有持续的 R01 资金，来自出色的研究环境和强大的实力 老年病学项目和大量潜在学员。