Histology Core Laboratory

组织学核心实验室

• 批准号: 8158329
• 负责人: david e kleiner
• 金额: $ 126.91万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8158329
• 关键词: Histology; Laboratories

The Histology Laboratory of the Laboratory of Pathology (LOP) is a core facility devoted to supporting the clinical activities of LOP. This consists of accessioning human tissues removed at surgery or in clinics, processing the tissues, preparing and staining slides for microscopy. Pathology residents are trained in techniques of gross dissection and learn to evaluate large and small specimen in preparation for microscopic evaluation. The lab also processes slides and blocks submitted from laboratories outside the NIH on NIH patients or non-NIH patients. Within the LOP, the Histology lab serves the Surgical Pathology, Hematopathology, Postmortem Pathology, Cytopathology, and Ultrastructural and Pediatric Pathology sections as well as the Specialized Diagnostics Unit. To date during FY10, about 22,000 tissue blocks were prepared from over 7,000 specimens and over 120,000 slides were cut and stained. Additionally, the laboratory processes case material sent in consultation or for review prior to protocol entry for patients in the Clinical Center. This fiscal year over 77,000 consult slides and 1372 blocks on over 6,400 cases were received. These numbers represent approximately stable volume from FY09 to FY10. Although about 95% of effort is devoted to clinical duties, the Histology Laboratory also performs recuts of tissue blocks and does some routine staining for research projects in NCI by arrangement. This activity is coordinated with the tissue research request function of Clinical Operations. The Histology Lab does not conduct primary research but supports the activities of many investigators.

病理学实验室（LOP）的组织学实验室是致力于支持LOP的临床活动的核心设施。这包括在手术或诊所中切除的人体组织，处理组织，制备和染色幻灯片以进行显微镜检查。病理学居民接受了剖析技术的培训，并学会了评估大小标本以准备微观评估。该实验室还处理NIH外的实验室提交的幻灯片和块，该幻灯片对NIH患者或非NIH患者。在LOP中，组织学实验室为手术病理学，血肿，验尸病理学，细胞病理学以及超微结构和儿科病理学以及专门的诊断单元。迄今为止，在第10财年期间，从7,000多个标本中制备了约22,000个组织块，并切割了120,000多个幻灯片。此外，在临床中心的患者输入方案之前，实验室工艺案例材料在咨询或审查之前进行了审查。本财政年度超过77,000张咨询幻灯片和1372个街区，收到了6,400多个案件。这些数字代表从09财年到1财年大约稳定的体积。尽管大约95％的努力致力于临床职责，但组织学实验室还进行了组织块的恢复，并通过安排对NCI的研究项目进行一些常规染色。该活动与临床操作的组织研究请求功能协调。组织学实验室不进行主要研究，而是支持许多研究者的活动。