Postmortem Pathology

尸检病理学

• 批准号: 8554073
• 负责人: david e kleiner
• 金额: $ 55.01万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8554073
• 关键词: Acquired Immunodeficiency Syndrome; Aplastic Anemia; Arts; Autopsy; Cause of Death; Cessation of life; Chronic Granulomatous Disease; Clinical; Clinical Investigator; Clinical Pathology; Clinical Protocols; Clinical Research; Databases; Dementia; Disease; Genetic; Glioma; Goals; Hematologic Neoplasms; Hospitals; Hour; Human; Immunologic Deficiency Syndromes; Information Systems; Institutes; Intramural Research Program; Investigation; Job' s Syndrome; Laboratories; Magnetic Resonance Imaging; Malignant Neoplasms; Mission; Multiple Sclerosis; Mycobacterium Infections; Normal tissue morphology; Pathology; Patient Care; Patients; Procedures; Process; Protocols documentation; Pulmonary Pathology; Reporting; Research; Research Personnel; Research Project Grants; Research Subjects; Research Support; Science; Services; Specimen; Stem cells; System; Text; Time; Tissues; Training; United States National Institutes of Health; Viral hepatitis; clinical care; graft vs host disease; human tissue; melanoma; nervous system disorder; quality assurance; quality of death; tool; treatment response; tumor

The Postmortem Pathology Section provides a complete, 24 hour per day, 365 days per year service in autopsy pathology for the Clinical Center. All patients on protocols for any of the Institutes or the Clinical Center may have an autopsy performed by the Laboratory of Pathology at the discretion of the principle investigator. The results from autopsies are used to assess treatment response, to answer clinical questions at the time of death, to identify pathology that was unknown or misdiagnosed prior to death, and to provide for hospital and protocol quality assurance. In addition, when the use and study of human pathological material is requested by research staff of any of the categorical institutes, the Postmortem Section makes every effort to collaborate with and/or supply the researchers with the human tissues upon approved request. (The Laboratory of Pathology has a standard procedure for tissue requests.) The autopsy material is utilized by NIH staff and fellows for research projects involving clinicopathological correlation and characterization of disease processes. Currently, several projects are on-going: clinical-pathological studies in dementia; culture of glioma stem cells from post-mortem tumor specimens; MRI correlations with normal tissue and de-myelinating disease (multiple sclerosis); investigation into Job syndrome and chronic granulomatous disease; characterization of pulmonary pathology in patients with non-tuberculous mycobacterial infection and complications of graft-versus-host disease. A partial database of major autopsy findings from 1953 through the present is available and all findings from March, 1999 on are available on-line through the Laboratory of Pathology's Information System. This system contains the full text of all autopsy reports. Texts of final reports are also available in the Clinical Research Information System (CRIS) after sign-out. In addition to its primary clinical responsibilities and research support function, the Post-mortem Pathology section is responsible for training pathology residents in the art and science of autopsy pathology. Diseases with deaths investigated in 2011 include AIDS, hematological malignancies, melanoma, gliomas, non-AIDS immunodeficiencies, viral hepatitis, and aplastic anemia.

验尸病理学部分每天为临床中心提供尸检病理学的每天24小时，每年365天。所有机构或临床中心方案方案的患者均可酌情由病理实验室进行尸检。尸检的结果用于评估治疗反应，在死亡时回答临床问题，以确定死亡前未知或误诊的病理，并提供医院和方案质量保证。此外，当任何一个分类机构的研究人员都要求对人类病理材料的使用和研究时，验尸部分会尽一切努力与研究人员在批准的请求下与研究人员合作和/或为研究人员提供人体组织。 （病理学实验室具有组织请求的标准程序。）NIH工作人员和研究员将尸检材料用于涉及临床病理学相关性和疾病过程表征的研究项目。目前，正在进行一些项目：痴呆症的临床病理研究；肿瘤后肿瘤标本中神经胶质瘤干细胞的培养；与正常组织和去层状疾病的MRI相关性（多发性硬化症）；研究工作综合征和慢性肉芽肿性疾病；肺病理学的肺病理学的表征和宿主疾病并发症的并发症。从1953年到当前的主要尸检结果的部分数据库，可以通过病理信息系统实验室在线获得所有发现，从1999年3月开始。该系统包含所有尸检报告的全文。登录后的临床研究信息系统（CRIS）也可以找到最终报告的文本。除了其主要的临床责任和研究支持功能外，“验尸病后病理”部分还负责训练尸检艺术和科学的病理居民。 2011年调查的死亡疾病包括艾滋病，血液恶性肿瘤，黑色素瘤，神经胶质瘤，非AIDS免疫缺陷，病毒性肝炎和性贫血。