Hawaii Pacific Islands Mammography Registry
夏威夷太平洋岛屿乳腺X线摄影登记处
基本信息
- 批准号:10819068
- 负责人:
- 金额:$ 5.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-08 至 2028-02-29
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAdultAdvanced Malignant NeoplasmAmerican SamoaArtificial IntelligenceAsianAsian AmericansAsian populationBiological MarkersBlack raceBody mass indexBreastBreast Cancer DetectionBreast Cancer Risk FactorBreast biopsyCaliforniaCancer CenterCharacteristicsChineseClinicClinicalClinical TrialsDataDatabasesEarly DiagnosisEarly treatmentEthnic OriginEthnic PopulationFamily history ofFilipinoFrequenciesGoalsGuamHawaiiHealthHigh Risk WomanHispanicImageIncidenceJapanJapaneseJapanese AmericanLife Style ModificationMachine LearningMalignant NeoplasmsMammographic screeningMammographyMeasuresMissionModelingMorbidity - disease rateNative HawaiianNative Hawaiian or Other Pacific IslanderNot Hispanic or LatinoObesityPacific IslanderPacific IslandsPatternPersonal SatisfactionPopulationPopulation HeterogeneityPopulation StudyPositioning AttributePrevalencePreventionPublic HealthRecording of previous eventsRegistriesResearch PersonnelResearch SupportResourcesRiskRisk FactorsRisk ReductionSamplingSan FranciscoSourceTestingTextureUnited States National Institutes of HealthUniversitiesWeight GainWomanadvanced breast cancerbreast densitybreast imagingcalcificationcancer invasivenesscancer riskclinical riskcohortdata registrydensitydigitaldisorder preventionethnic differenceethnic diversityexperiencehigh riskhuman diseaseimaging biomarkerimprovedimproved outcomemalignant breast neoplasmmammography registrymembermortalitynext generationnovelparent projectprogramsracial differenceracial populationradiomicsreproductiverisk predictionscreeningtumor registry
项目摘要
PARENT PROJECT SUMMARY / ABSTRACT
Despite recent advances in early detection and treatment, breast cancer remains a major cause of morbidity
and mortality. Native Hawaiian women have the highest breast cancer incidence in Hawaii despite their
favorable reproductive patterns. Japanese American women now experience the same breast cancer risk as
non-Hispanic White women Further, advanced breast cancer rates are considerably higher in Asian American
Women in Hawaii and the Pacific compared to the US mainland, 15% versus 9%. The absolute risk of invasive
cancer and advanced cancer in these groups of the US population is not known. Our long-term goal is to
develop accurate and validated breast cancer risk biomarkers that can contribute to screening strategies for
Asian groups with diverse breast cancer risk profiles who to date have not been well represented in breast
cancer cohorts and clinical trials. The Hawaii Pacific Islands Mammography Registry (HIPIMR) will be the
source to identify and validate novel image biomarkers for the diverse ethnic groups of this region with varying
risk factor profiles including Native Hawaiians, Japanese, Filipino, Chinese, and other ethnic groups.
Combining San Francisco Mammography Registry and HIPIMR cohorts will give us the statistical power to
describe the risk of invasive and advanced cancer in Asian groups. Our central hypothesis is that standard
breast cancer risk factors and image factors and their prevalence are different in the diverse populations found
in high concentrations in the Pacific (Hawaii, Guam, American Samoa) and Asian ethnic groups in the
mainland US compared to non-Hispanic White, non-Hispanic Black and Hispanic women. We plan to test the
hypothesis that using risk factor profiles and next-generation breast composition and texture features across
Asian groups, the fastest growing segment of the US population,9 and NHPI ethnic groups will improve cancer
risk prediction. Our specific aims are as compared to non-Hispanic White women: 1. Examine clinical risk
factors and their association with invasive and advanced breast cancer in women undergoing breast cancer
screening by Asian (Japanese, Filipino, Chinese) and Native Hawaiian Pacific Islander (AANHPI) ancestry, 2.
Identify next-generation breast imaging characteristics from 2D and 3D mammography, including volumetric
breast density, calcifications, masses, texture features, and their association with invasive and advanced
breast cancer for AANHPI women, using advanced artificial intelligence and machine learning approaches, 3.
Identify the combination of clinical risk factors and image factors associated with invasive and advanced breast
cancer risk among AANHPI women. This study addresses the need for accurate identification of defined
clinical and radiomic risk factors among AANHPI populations and their relation to breast cancer risk to improve
outcomes for these women.
父项目摘要/摘要
尽管最近在早期检测和治疗方面取得了进展,但乳腺癌仍然是发病的主要原因
和死亡率。夏威夷原住民女性的乳腺癌发病率是夏威夷最高的,尽管她们
有利的繁殖模式。日裔美国女性现在面临与美国女性相同的乳腺癌风险
非西班牙裔白人女性 此外,亚裔美国人的晚期乳腺癌发病率要高得多
夏威夷和太平洋地区的女性比例与美国大陆相比,分别为 15% 和 9%。侵入性的绝对风险
美国人口中这些群体的癌症和晚期癌症尚不清楚。我们的长期目标是
开发准确且经过验证的乳腺癌风险生物标志物,有助于制定乳腺癌筛查策略
具有不同乳腺癌风险特征的亚洲群体迄今为止在乳腺癌方面尚未得到充分体现
癌症队列和临床试验。夏威夷太平洋岛屿乳腺 X 线摄影登记处 (HIPIMR) 将是
来源来识别和验证该地区不同种族群体的新颖图像生物标志物
风险因素概况包括夏威夷原住民、日本人、菲律宾人、中国人和其他族裔群体。
结合旧金山乳腺 X 线摄影登记处和 HIPIMR 队列将为我们提供统计能力
描述亚洲群体患侵袭性癌症和晚期癌症的风险。我们的中心假设是标准
乳腺癌危险因素和影像因素及其患病率在不同人群中存在差异
太平洋地区(夏威夷、关岛、美属萨摩亚)和亚洲族群高度集中
美国大陆与非西班牙裔白人、非西班牙裔黑人和西班牙裔女性的比较。我们计划测试
假设使用风险因素概况和下一代乳房成分和纹理特征
亚洲群体(美国人口中增长最快的群体)9 和 NHPI 族群将改善癌症
风险预测。与非西班牙裔白人女性相比,我们的具体目标是: 1. 检查临床风险
因素及其与乳腺癌女性浸润性和晚期乳腺癌的关系
按亚洲人(日本人、菲律宾人、中国人)和夏威夷太平洋岛民 (AANHPI) 血统进行筛选,2。
从 2D 和 3D 乳房 X 线摄影中识别下一代乳房成像特征,包括体积
乳腺密度、钙化、肿块、纹理特征及其与侵入性和晚期的关系
使用先进的人工智能和机器学习方法治疗 AANHPI 女性乳腺癌,3.
确定与侵入性和晚期乳腺相关的临床危险因素和影像因素的组合
AANHPI 女性的癌症风险。这项研究解决了准确识别已定义的
AANHPI 人群的临床和放射学危险因素及其与乳腺癌风险的关系,以改善
这些妇女的结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KARLA M KERLIKOWSKE其他文献
KARLA M KERLIKOWSKE的其他文献
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{{ truncateString('KARLA M KERLIKOWSKE', 18)}}的其他基金
Evaluation of novel tomosynthesis density measures in breast cancer risk prediction
新型断层合成密度测量在乳腺癌风险预测中的评价
- 批准号:
10680241 - 财政年份:2023
- 资助金额:
$ 5.55万 - 项目类别:
Hawaii Pacific Islands Mammography Registry
夏威夷太平洋岛屿乳腺X线摄影登记处
- 批准号:
10588112 - 财政年份:2023
- 资助金额:
$ 5.55万 - 项目类别:
New Risk Assessment Paradigm to Predict Screening Detection, Failures and False Alarms
新的风险评估范式可预测筛查检测、故障和误报
- 批准号:
9982825 - 财政年份:2020
- 资助金额:
$ 5.55万 - 项目类别:
New Risk Assessment Paradigm to Predict Screening Detection, Failures and False Alarms
新的风险评估范式可预测筛查检测、故障和误报
- 批准号:
9279002 - 财政年份:2017
- 资助金额:
$ 5.55万 - 项目类别:
Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detection
乳腺实质的放射组学表型及其与乳腺癌风险和检测的关联
- 批准号:
9897495 - 财政年份:2017
- 资助金额:
$ 5.55万 - 项目类别:
Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response
用于估计乳腺癌风险和治疗反应的自动密度测量
- 批准号:
8601620 - 财政年份:2013
- 资助金额:
$ 5.55万 - 项目类别:
Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response
用于估计乳腺癌风险和治疗反应的自动密度测量
- 批准号:
9120340 - 财政年份:2013
- 资助金额:
$ 5.55万 - 项目类别:
Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response
用于估计乳腺癌风险和治疗反应的自动密度测量
- 批准号:
8693976 - 财政年份:2013
- 资助金额:
$ 5.55万 - 项目类别:
Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response
用于估计乳腺癌风险和治疗反应的自动密度测量
- 批准号:
8913697 - 财政年份:2013
- 资助金额:
$ 5.55万 - 项目类别:
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