MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)

通过刺激住院医师研究参与 MGH 衰老途径疾病 (MGH DAP StARR)

基本信息

批准号：
10592226
负责人：
BRADLEY T. HYMAN
金额：
$ 26.87万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-15 至 2027-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10592226
关键词：
Address Adult Aging Alzheimer&apos s disease related dementia Area Basic Science Bioinformatics Biological Markers Biomedical Research Boston Cardiovascular Diseases Clinical Clinical Medicine Clinical Research Communication Communities Coupled Dedications Dementia Development Disease Early Diagnosis Environment Faculty Fellowship Financial Hardship Fostering Foundations Functional disorder Funding Future Gastrointestinal Diseases General Hospitals General Population Goals Health Hospitalists Individual Inpatients Institution Intellectual Interest Investigation Knowledge Laboratories Laboratory Research Leadership Life Link Massachusetts Measures Medical Medicine Mentors Mentorship Metabolic Diseases Methodology Modeling Myopathy Neurodegenerative Disorders Neurology Parkinson Disease Participant Pathway interactions Patient Care Patients Physician Assistants Physicians Play Prevalence Productivity Quality of life Readiness Research Research Personnel Research Project Grants Residencies Role Science Scientist Solid Specific qualifier value Structure Therapeutic Time Training Training Programs Translating Translational Research Work age related aging population apprenticeship career clinical investigation cost design diagnostic tool frailty imaging modality implementation strategy improved innovation interest multidisciplinary multiple chronic conditions new technology next generation novel therapeutics programs role model skeletal disorder skill acquisition skills statistics symposium tool

项目摘要

PROJECT SUMMARY Physician-scientists play a unique role in bridging the gap between basic science and clinicians through the identification of important clinical questions and translating results to improve patient care. Regrettably, the physician-scientist workforce has continued to diminish, which may lead to negative, long-lasting consequences in biomedical research. Many residency programs focus heavily on acquiring medical knowledge as opposed to fostering intellectual curiosity and an introduction into the biomedical research field. Furthering the diminishing interest in a career as a physician-scientist is the ability to identify an encouraging and successful mentor. There is a critical need for a renewed emphasis on established physician- scientists as role models to trainees. In this proposal, we aim to enhance attractiveness and preparedness for a career as a physician-scientist during residency training. Alzheimer’s disease and related dementias (ADRD), frailty, and multimorbidity in aging are fundamental areas of science that greatly benefit from a robust physician-scientist workforce. The overall goal of this training program in ADRD, frailty, and multimorbidity in aging is to raise interest and preparedness of future physician-scientists to tackle the problems facing the aging population by providing a solid foundation to train residents to be productive, independent scientists who can advance studies in a broad range of areas from basic science to clinical investigation. To this end, we propose the implementation of the Massachusetts General Hospital Diseases of Aging Pathway via Stimulating Access to Research in Residency (MGH DAP StARR) program. The program will train new physician-scientists throughout the biomedical research continuum who will promote new preventative and therapeutic measures for aging-related diseases. The MGH DAP StARR program is centered around the following four objectives: [1] engage in the creation of important scientific contributions through strong, longitudinal mentorship with an emphasis on leadership essentials; [2] develop laboratory, translational, or clinical research approaches necessary to conduct high- quality research in pertinent areas of aging; [3] formulate hypothesis-based research questions, development and execution of a research project, and effectively communicate the significance of their science with intense mentorship from NIA- funded investigators; and [4] establish a pathway for continued development as independent physician-scientists in ADRD, frailty, and multimorbidity in aging. MGH DAP StARR program will allow two residents from the Departments of Medicine and Neurology at MGH to conduct research for 12-24 months at MGH or the Marcus Institute of Aging Research at Hebrew Senior Life Institute of Aging. The program will be co-led by Christine Ritchie (Medicine), Bradley Hyman (Neurology), and Jatin Vyas (Medicine Residency Program Director), an Internal Steering Committee, and External Advisory Board, along with 64 multidisciplinary and NIA-funded research preceptors. Together, these initiatives are designed to attract, train, and retain MDs in biomedical investigation in the areas of ADRD, frailty, and multimorbidity in aging at the most critical juncture of their career - residency training.

项目概要医生科学家通过识别在弥合基础科学和资助者之间的差距方面发挥着独特的作用遗憾的是，医生科学家团队正在研究重要的临床问题并转化结果以改善患者护理。持续减少，这可能会给许多生物医学研究带来负面的、长期的后果。课程主要侧重于获取医学知识，而不是培养求知欲和介绍进一步进入生物医学研究领域的能力是对医生科学家职业兴趣的减弱。确定一位令人鼓舞且成功的导师迫切需要重新重视已建立的医生。科学家作为受训者的榜样在这项提案中，我们的目标是增强对职业的吸引力和准备。住院医师培训期间的医师科学家。衰老过程中的多发病是科学的基本领域，强大的医师科学家队伍极大地受益于这一领域。该培训计划的总体目标是提高 ADRD、虚弱和老年多重病的兴趣和准备未来的医师科学家通过提供坚实的培训基础来解决人口老龄化所面临的问题居民成为富有成效的、独立的科学家，他们可以推进从基础科学到广泛领域的研究为此，我们建议麻省总医院实施疾病研究。通过促进住院医师研究的老龄化途径 (MGH DAP StARR) 计划该计划将进行培训。贯穿生物医学研究连续体的新医师科学家将促进新的预防和治疗 MGH DAP StARR 计划围绕以下四个目标：[1] 通过强有力的、纵向的指导来创造重要的科学贡献，重点是领导要素；[2] 开发进行高水平研究所需的实验室、转化或临床研究方法老龄化相关领域的高质量研究；[3] 制定基于假设的研究问题、开发和执行的研究项目，并在 NIA 的大力指导下有效地传达其科学的重要性资助研究人员；以及 [4] 建立一条作为 ADRD 独立医师科学家持续发展的途径， MGH DAP StARR 计划将允许来自医学部的两名住院医师进行治疗。 MGH 和神经病学在 MGH 或希伯来大学马库斯衰老研究所进行为期 12-24 个月的研究该项目将由 Christine Ritchie（医学）、Bradley Hyman（神经病学）共同领导。和 Jatin Vyas（住院医师项目主任）、内部指导委员会和外部顾问委员会，与 64 名多学科和 NIA 资助的研究导师一起，这些举措旨在吸引，培训并保留 ADRD、虚弱和老龄化多发病领域生物医学研究领域的医学博士他们职业生涯中最关键的时刻——住院医师培训。