Massachusetts Alzheimer's Disease Research Center

马萨诸塞州阿尔茨海默病研究中心

基本信息

批准号：
10378606
负责人：
BRADLEY T. HYMAN
金额：
$ 330.67万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10378606
关键词：
Alzheimer&apos s Disease Amyloid beta-Protein Authorization documentation Autopsy Basic Science Behavioral Biological Assay Biological Markers Blood Blood Vessels Cerebrospinal Fluid Clinical Clinical Data Clinical Research Clinical Sciences Clinical Trials Clinical Trials Design Cognitive Collaborations Communities Data Data Linkages Data Set Dementia Development Diagnosis Diagnostic Services Disease Education Environment Event Faculty Faculty Recruitment Fertilization Frontotemporal Dementia Functional disorder Future General Hospitals Goals Heterogeneity Image Imaging Techniques Impairment Individual Infrastructure Institution Knowledge Laboratories Leadership Learning Lesion Lewy Body Disease Link MRI Scans Marshal Massachusetts Measures Mentors Methods Mission Molecular Profiling Natural Immunity Nerve Degeneration Neurofibrillary Tangles Neuropsychology Participant Pathology Patients Phenotype Plasma Play Population Heterogeneity Positron-Emission Tomography Process Prognosis Research Research Methodology Research Personnel Research Support Resources Role Sampling Science Scientist Statistical Data Interpretation Structure Techniques Technology Testing Therapeutic Trials Training Training Programs Update Work base biomarker validation clinical biomarkers clinical center clinical phenotype cohort community setting digital disease heterogeneity education research follow-up frontotemporal degeneration imaging biomarker imaging study induced pluripotent stem cell inflammatory marker inter-individual variation medical schools mild cognitive impairment multidisciplinary neuroimaging neuropathology new technology next generation outreach posters programs racial and ethnic recruit resilience symposium targeted biomarker tau Proteins therapeutic evaluation therapeutic target tool validation studies

项目摘要

OVERVIEW: Massachusetts Alzheimer’s Disease Research Center (MADRC) The MADRC is an interdisciplinary Center at Massachusetts General Hospital, Harvard Medical School, with two major strategic goals: 1) to understand the underpinnings of heterogeneity of Alzheimer’s disease and Alzheimer’s Disease Related Disorders, and 2) to develop techniques, strategies, and technologies to accelerate a cure. To approach these goals, we propose 7 Cores (Administrative, Clinical, Biomarker, Imaging, Neuropathology, Data, and Outreach). We will use advanced Imaging, Biomarker, and analytic approaches to study our Research Cohort, which we view as a state of the art clinical phenotyping laboratory. Autopsy follow up for validation of biomarkers and imaging, and therapeutic targets, is essential. We plan to study a diverse population, both in the sense of various pathophysiologies, and also with varying racial and ethnic backgrounds, and rely on a vigorous ORE core both to fulfill our own recruitment needs and to support clinical trials and other affiliated programs. We have refocused our Center’s activities by remodeling the Research Cohort to include subjects who are cognitively normal, have mild cognitive impairment, or dementia, targeting diverse causes of dementia including Alzheimer’s disease and related disorders (Frontotemporal dementia, Lewy Body Disease, and vascular lesions). We postulate that heterogeneity of progression, even among individuals with the same “disease”, reflects underlying differences that can be uncovered, and that doing so will enhance clinical trial design by parsing variability from the very large, long cohort trials now in common use. Each Core is challenged to develop tools to help accelerate a cure – from intermediate imaging/biomarker targets that may help with diagnosis (a patient’s state) or prognosis (a patient’s fate), to performing autopsies to validate those targets. We will develop markers of inflammation and neurodegeneration, believing that innate immunity and resilience play a role in addition to tangles and plaques. Development of statistical and data methods are critical for anlaysis. These tools will allow us to test hypotheses about faster or slower rates of progression in a deeply phenotyped cohort. A final goal, central to our mission, is to build the future by training the next generation of scientists, which we propose to do under the framework of the Research Education Component. Together, we hope to make a difference in these devastating diseases.

概述：马萨诸塞州阿尔茨海默病研究中心 (MADRC) MADRC 是哈佛医学院马萨诸塞州总医院的一个跨学科中心，两个主要战略目标：1）了解阿尔茨海默病异质性的基础和阿尔茨海默病相关疾病，以及 2) 开发技术、策略和技术来为了加速治愈，我们提出了 7 个核心（管理、临床、生物标志物、我们将使用先进的成像、生物标记和分析。研究我们的研究队列的方法，我们将其视为最先进的临床表型实验室。我们计划进行尸检随访以验证生物标志物和成像以及治疗靶标。研究不同的人群，无论是在不同的病理生理学意义上，还是在不同的种族和群体中种族背景，并依靠充满活力的 ORE 核心来满足我们自己的招聘需求并支持临床试验和其他附属项目。我们通过重塑研究队列来重新调整我们中心的活动重点，以纳入以下对象：认知正常、有轻度障碍或痴呆，针对痴呆的多种原因包括阿尔茨海默病和相关疾病（额颞叶痴呆、路易体病和我们假设进展存在异质性，即使在具有相同症状的个体之间也是如此。 “疾病”，反映了可以发现的潜在差异，这样做将加强临床试验通过解析目前常用的大型、长期队列试验的变异性来进行设计。每个核心都面临着开发工具来帮助加速治愈的挑战——从中间成像/生物标志物可能有助于诊断（患者的状态）或预后（患者的命运）的目标，以进行尸检为了验证这些目标，我们将开发炎症和神经退行性变的标记物，相信除了缠结和斑块之外，先天免疫和恢复力也发挥着作用。数据方法对于分析至关重要。这些工具将使我们能够检验有关更快或更慢速率的假设。深度表型队列中的进展。我们使命的核心最终目标是通过培训下一代科学家来建设未来。建议在研究教育部分的框架下开展工作，我们希望共同做出一个。这些毁灭性疾病的差异。