Neural and Behavioral Indices of Balance Performance in Individuals with sensory loss

感觉丧失个体平衡表现的神经和行为指数

• 批准号: 10751174
• 负责人: Brittani A Morris
• 金额: $ 4.13万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10751174
• 关键词: Activities of Daily Living; Adult; Affect; Age; Anatomy; Attention; Auditory; Auditory system; Behavior; Behavior assessment; Behavioral; Brain; Clinical; Cognitive; Compensation; Complex; Conscious; Cues; Data; Data Set; Dependence; Development; Disease; Dizziness; Dorsal; Environment; Equilibrium; Evaluation; Exhibits; Eye; Functional Magnetic Resonance Imaging; Future; Gait; Goals; Health; Individual; Intervention; Knowledge; Literature; Measures; Mission; Motor; Movement; National Institute on Deafness and Other Communication Disorders; Network-based; Neurobiology; Participant; Pathway Analysis; Patients; Performance; Peripheral; Persons; Positioning Attribute; Postdoctoral Fellow; Posture; Public Health; Research; Resources; Rest; Sensorineural Hearing Loss; Sensory; Testing; United States; Vestibular loss; Vision; Visual; Visual attention; Work; analysis pipeline; balance testing; behavior measurement; equilibration disorder; fall risk; falls; follow-up; hearing impairment; improved; indexing; inner ear diseases; medical attention; motor control; neural; neural patterning; neuroimaging; normal hearing; sensory input; virtual reality environment; visual stimulus

ABSTRACT People with unilateral vestibular hypofunction (VH, peripheral disease of the inner ear) are thought to develop visual dependence. They get dizzy and off balance in complex visual environments. They sway more with dynamic visuals compared to static or with eyes closed compared to open. Individuals with UHL are not regularly assessed for balance function, but those with at least moderate hearing loss show increased risk for falls. Data from mechanistic studies in our lab have demonstrated that individuals with UHL do not increase postural sway in the presence of complex visual scenes as much as healthy controls, suggesting they are not as reliant on visual input to maintain their balance. Based on these findings, we hypothesize that individuals with UHL may reallocate attentional resources to motor control of balance (conscious movement processing) to compensate for the loss of auditory cues. To test the hypotheses of visual dependence in VH and conscious movement processing in UHL, this proposal will combine behavioral assessments of balance with analyses of network-based functional connectivity from resting-state functional magnetic resonance imaging (fMRI). The long-term goal of this research is to identify the neurobiological index explaining balance behavior and develop an intervention approach targeting functional connectivity differences that maximizes functional mobility gains in people with sensory loss. In the current project we will address the following Specific Aims: Aim 1: Identify balance profiles for people with VH and UHL. Individuals with VH, UHL and controls (N=24 each) will perform a battery of balance measures including static, dynamic, gait, and tests targeting sensory and cognitive aspects of balance. We will also analyze their postural sway from force plate data as they are tested in a virtual reality environment. Aim 2: Identify internetwork functional connectivity differences in VH, UHL, and healthy controls. Resting-state fMRI data will be acquired from VH and UHL (N=12 each) and compared to a distribution of healthy control data. Aim 3: Determine the extent to which balance performance (Aim 1) correlate with neurobiological data (Aim 2) in VH and UHL. We will calculate correlations between postural sway data and ratio of attention-motor connectivity to attention-vision connectivity. If we accomplish our aims, we will identify which balance domains are most affected by vestibular and hearing loss and whether people with UHL should be regularly screened for balance performance. We will establish which brain connections are altered by sensory loss and the implications for balance. This knowledge will have important implications to public health for improved assessment of balance and development of future interventions in VH and UHL.

抽象的 患有单侧前庭功能减退（VH，内耳周围疾病）的人 认为发展视觉依赖。他们在复杂的视觉中感到头晕和失去平衡 环境。与静态或闭上眼睛相比，它们在动态视觉效果中摇摆得更多 与开放相比。患有 UHL 的人不会定期接受平衡功能评估，但那些 至少有中度听力损失的人跌倒的风险增加。来自机械研究的数据 我们的实验室已经证明患有 UHL 的人不会增加身体的姿势摇摆 复杂视觉场景的存在与健康对照一样多，表明它们不那么依赖 通过视觉输入来保持平衡。基于这些发现，我们假设个体 UHL 可能会将注意力资源重新分配到平衡的运动控制（有意识的运动 处理）以补偿听觉线索的损失。检验视觉假设 VH 的依赖性和 UHL 中的有意识运动处理，该提案将结合 通过基于网络的功能连接分析进行平衡行为评估 静息态功能磁共振成像（fMRI）。本研究的长期目标 是确定解释平衡行为的神经生物学指标并制定干预措施 针对功能连接差异的方法，可最大限度地提高功能移动性收益 感觉丧失的人。在当前的项目中，我们将实现以下具体目标： 1：确定 VH 和 UHL 患者的平衡状况。具有 VH、UHL 和控制功能的个人 （每人 N=24）将执行一系列平衡测量，包括静态、动态、步态和测试 针对平衡的感官和认知方面。我们还将分析他们的姿势摇摆 在虚拟现实环境中测试的测力台数据。目标 2：识别互联网络 VH、UHL 和健康对照的功能连接差异。静息态 fMRI 数据将 从 VH 和 UHL（各 N=12）获取并与健康对照数据的分布进行比较。 目标 3：确定平衡表现（目标 1）与神经生物学的相关程度 VH 和 UHL 中的数据（目标 2）。我们将计算姿势摇摆数据和比率之间的相关性 注意力-运动连接到注意力-视觉连接。 如果我们实现了我们的目标，我们将确定哪些平衡领域受到的影响最大 前庭和听力损失以及 UHL 患者是否应该定期筛查 平衡性能。我们将确定哪些大脑连接会因感觉丧失而改变 对平衡的影响。这些知识将对公共卫生产生重要影响 改进了对 VH 和 UHL 未来干预措施的平衡和发展的评估。