Vaping Nicotine and Cannabis Across Adolescence and Young Adulthood

青少年和青年时期吸食尼古丁和大麻

基本信息

批准号：
10747805
负责人：
Jessica Louise Barrington-Trimis
金额：
$ 13.07万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10747805
关键词：
Address Adolescence Adolescent and Young Adult Adverse effects Aftercare Age Age Months Award Back Behavioral Cannabinoids Cannabis Characteristics Chronic Cigarette Community Health Cross-Sectional Studies Data Decision Making Dedications Dependence Development Disease Drug usage Education Electronics Emotional Environment Epidemic Expectancy Female Flavoring Freedom Friends Future Gender Health Individual Inhalation Intervention Interview JUUL Left Life Experience Malignant Neoplasms Marijuana Smoking Measures Modeling Moods Motivation Nicotine Oils Oral Outcome Parents Participant Pattern Persons Plants Play Policies Population Predisposition Prevention Prevention strategy Problem behavior Proliferating Public Health Relapse Reporting Research Rewards Risk Risk Factors Role Schools Self Administration Smoking Social Environment Stress Students Surveys Technology Testing Tobacco Tobacco use Tobacco-Related Carcinoma Uncertainty Variant Waxes Women&apos s Health Youth adverse outcome aged biopsychosocial catalyst cigarette smoking cohort combustible tobacco coping craving design deviant electronic cigarette use emerging adult emotion regulation empowerment experience experimental study flexibility habituation health goals heated tobacco products high-risk adolescents insight intergenerational male marijuana use marijuana vaping multiple drug use nicotine exposure nicotine use ninth grade novel parent grant parent project pleasure polysubstance use prevent programs progression risk public health priorities recruit response self esteem smoking initiation social substance use theories therapy design tobacco products trend uptake vaping vaping nicotine young adult

项目摘要

PROJECT SUMMARY (PARENT AWARD R01CA229617) In 2015, evidence that e-cigarette use ("vaping") in adolescents and young adults (AYAs) had increased and was associated with increased risk of cigarette smoking initiation generated concern in the public health community. Subsequent research has left the field with several critical questions, including: (1) whether vaping truly has a causal effect on smoking or merely reflects a common liability toward deviancy among 'high-risk' AYAs with emotional or behavioral problems, (2) whether an emerging wave of new vaping products, including new nicotine products such as JUUL, and an increasingly diverse class of products dedicated to vaping cannabis plant, oils, and waxes, may increase the appeal and addictive potential of vaping, and (3) whether there exist particular characteristics of vaping products and biopsychosocial mechanisms that underlie the risk of AYA vaping initiation, progression, and transition to other forms of drug use that could be targeted in prevention efforts. The uncertainties regarding the impact of AYA vaping have left policy officials with little evidence to determine if AYA vaping should be prioritized in public health programs, and if so, the most effective strategies for prevention. To address the evidence needs and provide a flexible framework for future study of the impact of various vaping products on the AYA tobacco product and cannabis use burden, we will test a novel 'catalyst model' of AYA vaping. The catalyst model proposes two steps, which we will evaluate in Aims 1 and 2 of this proposal. Step 1 (AIM 1 ). To determine whether (a) AYAs with fewer emotional-behavioral risk factors who have been previously deterred from drug use in traditional (non-vaporized) forms are at risk of vaping initiation, (b) the unique qualities and product features of vaping (e.g., concealability, flavors, appealing technology, social acceptability, low perceived harm) increase risk of AYA vaping, and (c) features of vaping products disproportionately increase the risk of vaping initiation for low-risk AYAs. Step 2 (AIM 2). To determine whether (a) vaping increases the risk of cross-product transitions involving initiation of other vaping products, or combustible nicotine or cannabis, as well as increases risk of progression to problematic drug use outcomes, including dependence, poly-drug use, and chronic drug use through early adulthood, (b) rewarding effects from exposure to nicotine, cannabinoids, and other product components (e.g. flavorings) increases risk of cross-product transitions and problematic drug use outcomes, and (c) product characteristics modify this association. To test the model, we will leverage data collected from participants from age 14-19 (2013-2018) from our existing cohort and follow participants into early adulthood (20-23, from 2019-2023; N-2000). We will also recruit a new cohort of 9th grade students at age 14 (N=2500) at the same schools as part of a cohort-sequential design that will apply causal inference analytic approaches to determine whether observed associations are likely causal. Collectively, this project will provide critical information regarding the priority and potential targets of public health efforts aimed at reducing the potential adverse public health effects resulting from AYA vaping, including tobacco-related cancer.

项目摘要（家长奖 R01CA229617） 2015 年，有证据表明青少年和年轻人 (AYA) 电子烟使用（“vaping”）有所增加，并且与开始吸烟的风险增加相关，这引起了公共卫生界的关注。随后的研究给该领域留下了几个关键问题，包括：（1）电子烟是否确实对吸烟有因果影响，还是仅仅反映了有情绪或行为问题的“高风险”AYA 中常见的偏差倾向，（2）是否新兴的新电子烟产品浪潮，包括 JUUL 等新尼古丁产品，以及专门用于电子烟大麻植物、油和蜡的日益多样化的产品，可能会增加电子烟的吸引力和成瘾潜力(3) 电子烟产品和生物心理社会机制是否存在特定特征，这些特征构成了 AYA 电子烟开始、进展和向其他形式的吸毒过渡的风险，这些风险可以作为预防工作的目标。 AYA 电子烟影响的不确定性使得政策官员几乎没有证据来确定 AYA 电子烟是否应在公共卫生计划中优先考虑，如果是的话，最有效的预防策略。为了满足证据需求并为未来研究各种电子烟产品对 AYA 烟草产品和大麻使用负担的影响提供灵活的框架，我们将测试 AYA 电子烟的新型“催化剂模型”。催化剂模型提出了两个步骤，我们将在本提案的目标 1 和目标 2 中对其进行评估。步骤1（目标1）。确定 (a) 情绪行为风险因素较少且之前已不再使用传统（非汽化）形式吸毒的 AYA 是否面临开始吸电子烟的风险，(b) 电子烟的独特品质和产品特征（例如，吸电子烟的独特性和产品特性）。、隐蔽性、口味、吸引人的技术、社会可接受性、低感知危害）增加 AYA 电子烟的风险，以及 (c) 电子烟产品的特征不成比例地增加电子烟的风险启动低风险 AYA。步骤 2（目标 2）。确定 (a) 电子烟是否会增加涉及开始使用其他电子烟产品或可燃尼古丁或大麻的跨产品转换的风险，以及增加发展成有问题的药物使用结果的风险，包括依赖、多种药物使用和成年早期长期吸毒，(b) 接触尼古丁、大麻素和其他产品成分（例如调味剂）带来的奖励效应会增加跨产品转换和有问题的吸毒结果的风险，以及(c) 产品特性改变这种关联。为了测试该模型，我们将利用现有队列中 14-19 岁（2013-2018）参与者收集的数据，并跟踪参与者进入成年早期（20-23 岁，2019-2023 年；N-2000）。我们还将在同一所学校招募一批新的 14 岁 9 年级学生 (N=2500)，作为队列序贯设计的一部分，该设计将应用因果推理分析方法来确定观察到的关联是否可能是因果关系。总的来说，该项目将提供有关公共卫生工作的优先事项和潜在目标的重要信息，旨在减少 AYA 电子烟对公共健康的潜在不利影响，包括与烟草相关的癌症。