Vaping Nicotine and Cannabis Across Adolescence and Young Adulthood

青少年和青年时期吸食尼古丁和大麻

基本信息

批准号：
10700931
负责人：
Jessica Louise Barrington-Trimis
金额：
$ 74.18万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-20 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10700931
关键词：
Address Adolescence Adolescent and Young Adult Adverse effects Age Age Months Anxiety Disorders Attention deficit hyperactivity disorder Behavioral California Cannabinoids Cannabis Cannabis policy Characteristics Chronic Cigarette Community Health Data Data Sources Dedications Dependence Development Devices Disease Drug abuse Drug usage Electronics Emotional Expectancy Flavoring Friends Future Health High School Student Impulsivity Inhalation Intervention JUUL Left Link Malignant Neoplasms Marijuana Smoking Measures Mediating Modeling Mood Disorders Nicotine Oils Outcome Participant Pharmaceutical Preparations Plants Play Policies Policy Maker Population Prevention Prevention strategy Problem behavior Proliferating Public Health Research Rewards Risk Risk Factors Role Sampling Schools Science Scientist Self Administration Smoking Students Surveys THC concentration Technology Testing Tobacco Tobacco use Tobacco-Related Carcinoma Uncertainty Variant Waxes Youth adverse outcome aged biopsychosocial catalyst cigarette smoking cohort combustible tobacco design deviant digital distress tolerance electronic cigarette use emerging adult experience experimental study flexibility follow-up habituation heated tobacco products high risk high school high-risk adolescents marijuana use marijuana vaping multiple drug use nicotine exposure nicotine use ninth grade novel prevent programs progression risk public health priorities public policy on tobacco recruit risk prediction smoking initiation social stem tobacco products trait uptake vaping vaping nicotine young adult

项目摘要

! PROJECT SUMMARY In 2015, evidence that e-cigarette use (“vaping”) in adolescents and young adults (AYAs) had increased and was associated with increased risk of cigarette smoking initiation generated concern in the public health community. Subsequent research has left the field with several critical questions, including: (1) whether vaping truly has a causal effect on smoking or merely reflects a common liability toward deviancy among ‘high-risk’ AYAs with emotional or behavioral problems, (2) whether an emerging wave of new vaping products, including new nicotine products such as JUUL, and an increasingly diverse class of products dedicated to vaping cannabis plant, oils, and waxes, may increase the appeal and addictive potential of vaping, and (3) whether there exist particular characteristics of vaping products and biopsychosocial mechanisms that underlie the risk of AYA vaping initiation, progression, and transition to other forms of drug use that could be targeted in prevention efforts. The uncertainties regarding the impact of AYA vaping have left policy officials with little evidence to determine if AYA vaping should be prioritized in public health programs, and if so, the most effective strategies for prevention. To address the evidence needs and provide a flexible framework for future study of the impact of various vaping products on the AYA tobacco product and cannabis use burden, we will test a novel ‘catalyst model’ of AYA vaping. The catalyst model proposes two steps, which we will evaluate in Aims 1 and 2 of this proposal. Step 1 (AIM 1). To determine whether (a) AYAs with fewer emotional-behavioral risk factors who have been previously deterred from drug use in traditional (non-vaporized) forms are at risk of vaping initiation, (b) the unique qualities and product features of vaping (e.g., concealability, flavors, appealing technology, social acceptability, low perceived harm) increase risk of AYA vaping, and (c) features of vaping products disproportionately increase the risk of vaping initiation for low-risk AYAs. Step 2 (AIM 2). To determine whether (a) vaping increases the risk of cross-product transitions involving initiation of other vaping products, or combustible nicotine or cannabis, as well as increases risk of progression to problematic drug use outcomes, including dependence, poly-drug use, and chronic drug use through early adulthood, (b) rewarding effects from exposure to nicotine, cannabinoids, and other product components (e.g. flavorings) increases risk of cross-product transitions and problematic drug use outcomes, and (c) product characteristics modify this association. To test the model, we will leverage data collected from participants from age 14-19 (2013-2018) from our existing cohort and follow participants into early adulthood (20-23, from 2019-2023; N~2000). We will also recruit a new cohort of 9th grade students at age 14 (N=2500) at the same schools as part of a cohort-sequential design that will apply causal inference analytic approaches to determine whether observed associations are likely causal. Collectively, this project will provide critical information regarding the priority and potential targets of public health efforts aimed at reducing the potential adverse public health effects resulting from AYA vaping, including tobacco-related cancer.

！项目概要 2015 年，有证据表明青少年和年轻人 (AYAs) 使用电子烟（“vaping”）的情况有所增加，并且与开始吸烟的风险增加有关，引起了公共卫生界的关注，随后的研究给该领域留下了几个关键问题，包括：（1）电子烟是否真的有效。对吸烟有因果影响或仅仅反映了“高风险”AYA 中常见的偏差行为存在情绪或行为问题，（2）是否出现了新的电子烟产品浪潮，包括新的 JUUL 等尼古丁产品，以及专门用于吸食大麻的日益多样化的产品植物、油和蜡，可能会增加电子烟的吸引力和成瘾潜力，以及（3）是否存在电子烟产品的特殊特征和生物心理社会机制构成了 AYA 电子烟开始、发展以及向其他形式的吸毒过渡的风险，这些风险可以作为预防工作的目标。 AYA 电子烟影响的不确定性使得政策官员几乎没有证据来确定是否 AYA 电子烟应该在公共卫生计划中得到优先考虑，如果是这样，最有效的预防策略应该是优先考虑的。满足证据需求并为未来研究各种电子烟的影响提供灵活的框架关于 AYA 烟草产品和大麻使用负担的产品，我们将测试 AYA 的新型“催化剂模型” 催化剂模型提出了两个步骤，我们将在本提案第 1 步的目标 1 和 2 中对其进行评估。（目标 1）确定 (a) 以前接受过治疗的 AYA 是否具有较少的情绪行为风险因素。阻止以传统（非汽化）形式使用药物的人面临开始吸电子烟的风险，(b) 独特的品质电子烟的产品特征（例如，隐蔽性、口味、吸引人的技术、社会可接受性、低感知危害）增加了 AYA 电子烟的风险，以及 (c) 电子烟产品的特征不成比例地增加了吸电子烟的风险。低风险 AYA 开始吸电子烟的风险步骤 2 (AIM 2) 确定 (a) 吸电子烟是否会增加以下风险：跨产品转型涉及启动其他电子烟产品或可燃尼古丁或大麻，例如并增加发展成有问题的药物使用结果的风险，包括依赖性、多种药物使用、和成年早期长期吸毒，(b) 接触尼古丁、大麻素的奖励效应，和其他产品成分（例如调味剂）增加了跨产品转换和有问题药物的风险使用结果，以及（c）产品特性修改了这种关联。为了测试模型，我们将利用数据。从我们现有队列中收集 14-19 岁（2013-2018）的参与者，并跟踪参与者进入早期成年期（20-23岁，2019-2023年；N~2000）我们还将招收一批新的14岁的9年级学生。（N=2500）在同一所学校作为队列序贯设计的一部分，该设计将应用因果推理分析总的来说，该项目将提供确定观察到的关联是否可能存在因果关系的方法。有关旨在减少 AYA 电子烟对公共健康的潜在不利影响（包括与烟草相关的癌症）的公共卫生工作的优先事项和潜在目标的重要信息。