Vaping Nicotine and Cannabis Across Adolescence and Young Adulthood

青少年和青年时期吸食尼古丁和大麻

基本信息

批准号：
10306912
负责人：
Jessica Louise Barrington-Trimis
金额：
$ 11.91万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-20 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10306912
关键词：
Address Administrative Supplement Adolescence Adolescent Adolescent and Young Adult Affect African American Age Attitude Behavioral Cannabinoids Cannabis Characteristics Chronic Community Health Data Data Analyses Dependence Discrimination Drug usage Electronic cigarette Electronics Emotional Ethnic Origin Ethnic group Flavoring Frequencies Future Health Hispanics Inhalation Intervention JUUL Knowledge Lead Left Marijuana Smoking Mental Health Minority Modeling Nicotine Outcome Participant Pattern Perception Plant Oils Play Policies Population Prevention Prevention strategy Problem behavior Public Health Race Reporting Research Rewards Risk Risk Factors Schools Smoking Social status Socioeconomic Status Stress Students Substance Use Disorder Substance-Related Disorders Surveys Technology Testing Tobacco Tobacco use Tobacco-Related Carcinoma Typology Uncertainty Waxes Youth adolescent substance use adverse outcome behavioral health biopsychosocial catalyst cigarette smoking cohort combustible tobacco design deviant electronic cigarette use emerging adult ethnic difference flexibility high-risk adolescents illicit drug use marijuana legalization marijuana use marijuana vaping multiple drug use never smoker nicotine exposure nicotine use novel parent grant polysubstance use programs racial and ethnic racial and ethnic disparities recruit risk perception smoking initiation social substance use tobacco products trend vaping vaping nicotine vapor young adult

项目摘要

In 2015, evidence that e-cigarette use ("vaping") in adolescents and young adults (AYAs) had increased and was associated with increased risk of cigarette smoking initiation generated concern in the public health community. Subsequent research has left the field with several critical questions, including: (1) whether vaping truly has a causal effect on smoking or merely reflects a common liability toward deviancy among 'high-risk' AYAs with emotional or behavioral problems, (2) whether an emerging wave of new vaping products, including new nicotine products such as JUUL, and an increasingly diverse class of products dedicated to vaping cannabis plant, oils, and waxes, may increase the appeal and addictive potential of vaping, and (3) whether there exist particular characteristics of vaping products and biopsychosocial mechanisms that underlie the risk of AYA vaping initiation, progression, and transition to other forms of drug use that could be targeted in prevention efforts. The uncertainties regarding the impact of AYA vaping have left policy officials with little evidence to determine if AYA vaping should be prioritized in public health programs, and if so, the most effective strategies for prevention. To address the evidence needs and provide a flexible framework for future study of the impact of various vaping products on the AYA tobacco product and cannabis use burden, we will test a novel 'catalyst model' of AYA vaping. The catalyst model proposes two steps, which we will evaluate in Aims 1 and 2 of this proposal. Step 1 (AIM 1). To determine whether (a) AYAs with fewer emotional-behavioral risk factors who have been previously deterred from drug use in traditional (non-vaporized) forms are at risk of vaping initiation, (b) the unique qualities and product features of vaping (e.g., concealability, flavors, appealing technology, social acceptability, low perceived harm) increase risk of AYA vaping, and (c) features of vaping products disproportionately increase the risk of vaping initiation for low-risk AYAs. Step 2 (AIM 2). To determine whether (a) vaping increases the risk of cross-product transitions involving initiation of other vaping products, or combustible nicotine or cannabis, as well as increases risk of progression to problematic drug use outcomes, including dependence, poly-drug use, and chronic drug use through early adulthood, (b) rewarding effects from exposure to nicotine, cannabinoids, and other product components (e.g. flavorings) increases risk of cross-product transitions and problematic drug use outcomes, and (c) product characteristics modify this association. To test the model, we will leverage data collected from participants from age 14-19 (2013-2018) from our existing cohort and follow participants into early adulthood (20-23, from 2019-2023; N~2000). We will also recruit a new cohort of 9ᵗʰ grade students at age 14 (N=2500) at the same schools as part of a cohort-sequential design that will apply causal inference analytic approaches to determine whether observed associations are likely causal. Collectively, this project will provide critical information regarding the priority and potential targets of public health efforts aimed at reducing the potential adverse public health effects resulting from AYA vaping, including tobacco-related cancer.

2015 年，有证据表明青少年和年轻人 (AYA) 使用电子烟（“vaping”）已增加并与开始吸烟的风险增加相关引起关注随后的研究给该领域留下了几个关键的问题。问题，包括：（1）电子烟是否确实对吸烟有因果影响，还是仅仅反映了吸烟的因果关系？具有情绪或行为问题的“高风险”AYA 中常见的偏差责任，(2) 是否会出现新的电子烟产品浪潮，包括 JUUL 等新尼古丁产品，以及专门用于吸食大麻植物、油和蜡的产品类别日益多样化，可能会增加电子烟的吸引力和成瘾潜力，以及（3）是否存在特定的电子烟产品的特征和构成 AYA 风险的生物心理社会机制电子烟的开始、进展以及向其他可能有针对性的药物使用形式的过渡 AYA 电子烟影响的不确定性给政策留下了空间。官员们几乎没有证据来确定 AYA 电子烟是否应该在公共卫生中优先考虑计划，如果是的话，最有效的预防策略。满足证据需求并为未来研究影响提供灵活的框架各种电子烟产品对 AYA 烟草产品和大麻使用负担的影响，我们将测试一种新颖的 AYA 电子烟的“催化剂模型” 催化剂模型提出了两个步骤，我们将在其中进行评估。本提案的目标 1 和 2 步骤 1 (AIM 1) 确定 (a) AYA 是否较少。以前在传统方法中被阻止使用药物的情绪行为危险因素（非汽化）形式面临着开始吸电子烟的风险，(b) 独特的品质和产品电子烟的特点（例如，隐蔽性、口味、吸引人的技术、社会可接受性、低感知到的危害）增加 AYA 电子烟的风险，以及 (c) 电子烟产品的特征不成比例地增加低风险 AYA 开始使用电子烟的风险步骤 2 (AIM 2)。确定 (a) 电子烟是否会增加涉及启动的跨产品转型的风险其他电子烟产品，或可燃尼古丁或大麻，以及增加风险进展为有问题的药物使用结果，包括依赖性、多种药物使用和慢性药物使用在成年早期使用，(b) 接触尼古丁、大麻素和大麻素的奖励效应其他产品成分（例如调味剂）会增加跨产品转换的风险，有问题的药物使用结果，以及 (c) 产品特性改变了这种关联。模型中，我们将利用从 14-19 岁（2013-2018）参与者那里收集的数据现有队列并跟踪参与者进入成年早期（20-23岁，2019-2023年；N~2000）。还将在同一所学校招收一批 14 岁的 9ᵗʰ 年级新学生 (N=2500) 队列序贯设计将应用因果推理分析方法来确定总的来说，该项目将提供关键的观察到的关联是否可能具有因果关系。有关旨在减少疾病的公共卫生努力的优先事项和潜在目标的信息 AYA 电子烟对公共健康造成的潜在不利影响，包括与烟草相关的影响癌症。