ECHO Renewal for the CANOE Study Cohort

CANOE 研究队列的 ECHO 更新

• 批准号: 10745082
• 负责人: Tina V Hartert
• 金额: $ 132.05万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745082
• 关键词: 2 year old; Address; Age; Asthma; Biological Process; Biological Specimen Banks; Birth; Black Populations; Bronchiolitis; COVID-19 pandemic; Child; Child Health; Childhood; Childhood Acute Lymphocytic Leukemia; Childhood Asthma; Cohort Studies; Collection; Communities; Conceptions; Data; Data Element; Development; Diagnosis; Disease; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Epithelial Cells; Funding; Goals; Hispanic Populations; Hypersensitivity; Incidence; Individual; Infant; Infection; Infrastructure; Intervention; Licensure; Life; Medical History; Mentors; Modification; Monoclonal Antibodies; Neonatal; Nose; Outcome; Participant; Population; Predisposition; Pregnant Women; Prevention; Prevention strategy; Preventive; Primary Prevention; Protocols documentation; Public Health; Publications; Recommendation; Recurrence; Research; Research Personnel; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus Vaccines; Respiratory syncytial virus; Risk; Rural Community; Sampling; Severities; Southeastern United States; Testing; Urban Community; Vaccines; Wheezing; Work; age related; airway epithelium; asthma prevention; chronic respiratory disease; cohort; cost-effectiveness evaluation; design; disorder prevention; diversity and inclusion; early life exposure; ethnic diversity; expectation; follow-up; infancy; infant infection; innovation; interest; low and middle-income countries; middle childhood; multi-racial; novel; pandemic disease; pandemic impact; policy implication; pregnant; prevent; public health intervention; pulmonary function; racial diversity; recruit; resilience factor; respiratory microbiome; retention rate; vaccine acceptance

ABSTRACT The overarching goals of this application are to: 1) maintain retention of children in the Vanderbilt CANOE birth cohort with emphasis on diversity and implementation of the ECHO Cohort Protocol with high fidelity and conduct new enrollment, and 2) address key questions in the field about one of the most common and modifiable early life environmental exposures consistently associated with significantly increased asthma risk, respiratory syncytial virus (RSV) infection, delineating the severity-dependent and age-dependent effects of RSV infection on asthma risk. This innovative project has significant public health impact, as establishing the age- and severity-dependent relationship between RSV and asthma is the first and most important step in disease primary prevention. We propose to address key unanswered questions in the field: the severity- and age-dependent association of RSV and asthma, and the impact of infection on lung function. In addition, we will explore the broad impact of the SARS-CoV-2 pandemic on asthma incidence and control in an exploratory aim, which may provide support for multi-faceted environmental modifications in asthma prevention and control, and data to inform the potential impact of broad public health interventions. The birth cohort that this application supports is the Vanderbilt CANOE (Childhood Allergy and the NeOnatal Environment) study. CANOE is a birth cohort designed to identify and understand how environmental factors modify the development of the airway epithelium. The study includes the unique longitudinal sampling of the child airway throughout the first year of life, and annually. The Vanderbilt CANOE study has unique early life exposure and outcomes ascertainment, including surveillance for RSV and a novel biospecimen repository of nasal airway epithelial cells. The CANOE cohort also has important information for longitudinal development of the airway microbiome and the airway epithelium. The proposed research is innovative and timely given the anticipated licensure of multiple RSV prevention products in the coming year (maternal vaccines and long- acting monoclonal antibodies for infants). The proposed work represents a novel, multi-faceted approach to identifying and understanding the influence of severity of RSV infection and age of RSV infection on asthma risk and lung function. The answers to these questions will be critical to developing prevention strategies and informing public health expectations for RSV non-pharmaceutical preventive strategies and evaluating potential long-term value-added benefits of vaccines in preventing lifelong chronic respiratory disease. These data may not only bolster RSV vaccine acceptability and uptake in the US, but will almost certainly be useful in evaluating the cost-effectiveness of RSV prevention strategies in low and middle income countries.

抽象的 此应用程序的总体目标是：1) 保持范德比尔特独木舟出生时儿童的保留 强调多样性和高保真度实施 ECHO 队列协议的队列 进行新的注册，并且 2) 解决该领域关于最常见和最常见的问题之一的关键问题 可改变的生命早期环境暴露始终与显着增加的哮喘风险相关， 呼吸道合胞病毒（RSV）感染，描述了严重程度依赖性和年龄依赖性影响 RSV 感染对哮喘风险的影响。这一创新项目具有重大的公共卫生影响，因为建立了 RSV 和哮喘之间的年龄和严重程度依赖性关系是第一步也是最重要的一步 疾病一级预防。我们建议解决该领域尚未解答的关键问题：严重性和 RSV 与哮喘的年龄依赖性关联，以及感染对肺功能的影响。此外，我们 将探讨 SARS-CoV-2 大流行对哮喘发病率和控制的广泛影响 目标，这可能为哮喘预防和治疗的多方面环境改变提供支持 控制和数据以告知广泛的公共卫生干预措施的潜在影响。 此应用程序支持的出生队列是范德比尔特 CANOE（儿童过敏和新生儿 环境）研究。 CANOE 是一个出生队列，旨在识别和了解环境因素如何影响 改变气道上皮的发育。该研究包括独特的纵向抽样 儿童气道贯穿生命的第一年，并且每年一次。范德比尔特 CANOE 研究具有独特的早期生命 暴露和结果确定，包括 RSV 监测和新型生物样本库 鼻气道上皮细胞。 CANOE 队列还具有纵向发展的重要信息 气道微生物组和气道上皮。鉴于以下情况，拟议的研究具有创新性和及时性 预计明年将获得多种 RSV 预防产品的许可（孕产妇疫苗和长期疫苗） 婴儿作用单克隆抗体）。拟议的工作代表了一种新颖的、多方面的方法 识别和了解 RSV 感染的严重程度和 RSV 感染的年龄对哮喘的影响 风险和肺功能。这些问题的答案对于制定预防策略和 告知公众健康对 RSV 非药物预防策略的期望并评估潜力 疫苗在预防终身慢性呼吸道疾病方面的长期增值效益。这些数据可能 不仅可以提高 RSV 疫苗在美国的接受度和使用率，而且几乎肯定会在以下方面发挥作用： 评估低收入和中等收入国家 RSV 预防策略的成本效益。