RSV to Asthma Cooperative Clinical Ascertainment and Biospecimen Research Core

RSV 与哮喘合作临床确定和生物样本研究核心

• 批准号: 8196536
• 负责人: Tina V Hartert
• 金额: $ 43.39万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8196536
• 关键词: 4 year old; Accident and Emergency department; Acute; Address; Age; Age-Months; Age-Years; Aliquot; Allergic; Allergic Disease; Argentina; Asthma; Blood; Bronchiolitis; Calendar; Caring; Child; Childhood; Childhood Asthma; Chronic; Chronic lung disease; Classification; Clinic; Clinical; Code; DNA; Data; Databases; Demographic Factors; Development; Diagnosis; Disease; Enrollment; Epidemiologist; Etiology; Family; Funding; Genetic; Genotype; Healthcare; Home visitation; Hospitals; House Call; Hypersensitivity; IgE; Immune; Immune response; Immunologist; Infant; Integration Host Factors; International; Intervention; Investigation; Lead; Life; Link; Lower Respiratory Tract Infection; Molecular; Monitor; Names; Nose; Outcome; Outcome Assessment; Phenotype; Physicians; Plasma; Questionnaires; Recording of previous events; Recruitment Activity; Recurrence; Recurrent disease; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Respiratory Syncytial Virus Infections; Respiratory Tract Infections; Respiratory syncytial virus; Risk; Role; Sampling; Scientist; Seasons; Severities; Severity of illness; Specimen; Symptoms; Telephone; Time; United States National Institutes of Health; Upper Respiratory Infections; Urine; Viral; Virus; Virus Diseases; Visit; Vulnerable Populations; Wheezing; Work; acronyms; atopy; base; cohort; comparison group; data management; early childhood; experience; follow-up; human DNA; improved; infancy; lung injury; pathogen; pediatrician; prospective; repository; respiratory; viral detection; virus genetics

CORE B: The purpose of this core is to establish and administer a prospective cohort, clinical database, and biospecimen repository that will enable research on the role of RSV in atopic and chronic lung disease inception. The core will support scientific projects that focus on host factors (Project 1), viral factors (Project 2), and mechanisms through which target interventions may work (Project 3). This core will prospectively enroll and follow 2000 term otherwise healthy infants who will be < 6 months of age during winter virus season through age 3-4 years, at which time recurrent childhood wheeze and allergic sensitization will be defined - named the ReSPIRA cohort (Respiratory Study for Protection of Infants from RSV to Asthma). The core will provide detailed clinical information and biospecimens on a tightly phenotyped group of infants with a high likelihood of developing asthma, and thus allows the projects which this core serves to identify host genetic, viral genetic, cellular, immune, and molecular determinants of recurrent wheezing, early childhood asthma and atopy following infant RSV infection. The first two years of the clinical core will focus on enrollment, and the 3 subsequent years will focus on cohort follow-up and delivery of data and biospecimens to co-investigators, whose projects will address research questions related to RSV illness and early childhood asthma. Our specific aims are to: (1) Create the ReSPIRA cohort; (2) Clinically characterize (phenotype) the infant cohort in Argentina with regards to RSV infection status, host response, and lung injury during infancy, on the outcomes of recurrent childhood wheezing, asthma, and atopy; and (3) Establish and maintain a biospecimen repository and distribute its' resources to conduct studies on the mechanisms through which RSV infection may lead to recurrent wheezing and asthma development. This core supports the overall Center by centralizing resources on cohort inception, detailed classification of RSV infection/exposure, outcomes assessments, data management and administration, to support the study of the role of infant RSV illness on later childhood atopy and asthma outcomes. As bronchiolitis and asthma are the most common, serious, acute and chronic conditions of infancy and childhood, respectively, and are diseases that disproportionately burden vulnerable populations, this core and supported projects will have major, long-lasting impact by improving our understanding of the role of, and the mechanisms through which RSV contributes to later childhood outcomes.

核心 B：该核心的目的是建立和管理前瞻性队列、临床数据库和 生物样本库将有助于研究 RSV 在特应性和慢性肺病中的作用 成立。该核心将支持关注宿主因素（项目 1）、病毒因素（项目 2) 以及目标干预措施发挥作用的机制（项目 3）。该核心将有望 招募并跟踪 2000 名在冬季病毒期间年龄 < 6 个月的健康足月婴儿 3-4岁的季节，此时会出现反复的儿童喘息和过敏性过敏 定义 - 命名为 ReSPIRA 队列（保护婴儿免受 RSV 至哮喘的呼吸研究）。 该核心将提供一组紧密表型婴儿的详细临床信息和生物样本 患哮喘的可能性很高，因此允许该核心用于识别的项目 反复喘息的宿主遗传、病毒遗传、细胞、免疫和分子决定因素、早期 婴儿 RSV 感染后的儿童哮喘和过敏症。临床核心的前两年将重点关注 入组，随后 3 年将重点关注队列随访和数据交付 生物样本给共同研究人员，他们的项目将解决与 RSV 疾病相关的研究问题和 儿童早期哮喘。我们的具体目标是： (1) 创建 ReSPIRA 队列； (2) 临床特征 （表型）阿根廷婴儿队列的 RSV 感染状态、宿主反应和肺部 婴儿期损伤，对儿童期反复喘息、哮喘和特应性的影响； (3) 建立 维护生物样本库并分配其资源以进行机制研究 RSV 感染可能导致反复喘息和哮喘发展。 该核心通过集中资源来支持整个中心的队列启动、详细分类 RSV 感染/暴露、结果评估、数据管理和管理，以支持研究 婴儿 RSV 疾病对儿童后期特应性和哮喘结局的作用。如细支气管炎和哮喘 分别是婴儿期和儿童期最常见、最严重、急性和慢性的疾病， 针对给弱势群体带来不成比例负担的疾病，这一核心项目和支持项目将 通过提高我们对作用及其机制的理解，产生重大、持久的影响 RSV 有助于儿童后期的发展。