Application of social cognitive theory to physical activity behavior among adults with Crohn's disease

社会认知理论在克罗恩病成人体力活动行为中的应用

• 批准号: 10745823
• 负责人: Whitney Neal
• 金额: $ 3.97万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-12-04 至 2025-12-03
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745823
• 关键词: Accelerometer; Adult; Affect; Age; Albumins; Area; Behavior; Behavioral; Biological; Biological Markers; C-reactive protein; CD6 antigen; Chronic; Chronic Disease; Clinical; Clinical Trials Design; Community Practice; Complex; Control Groups; Crohn' s disease; Development; Devices; Disease; Disease Outcome; Familiarity; Foundations; Future; General Population; Goals; Health Benefit; Health Care Costs; Health Promotion; Histologic; Individual; Inflammatory; Informal Social Control; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Leukocyte L1 Antigen Complex; Measures; Medical Records; Mentorship; Methodology; Mucous Membrane; Muscle function; Operative Surgical Procedures; Outcome; Participant; Patient Care; Patient Self-Report; Pattern; Pharmaceutical Preparations; Physical activity; Physical assessment; Play; Population; Postoperative Period; Public Health; Questionnaires; Reporting; Research; Research Personnel; Research Proposals; Role; Sample Size; Sampling; Scientist; Self Assessment; Self Efficacy; Social support; Solid; Specificity; Statistical Methods; Surgeon; Testing; Therapeutic Effect; Training; Translating; Translational Research; Translations; Ulcerative Colitis; behavior change; cardiorespiratory fitness; career; clinical application; clinical practice; clinical remission; design; evidence base; exercise intervention; expectation; healing; improved; indexing; programs; psychosocial; responsible research conduct; sedentary; sedentary lifestyle; sex; skills; social cognitive theory; sound; therapy development; treatment program

PROJECT SUMMARY/ABSTRACT Crohn’s disease (CD), which affects over 500,000 individuals with CD in the US, is a chronic and uniquely challenging condition that requires lifelong medications, major surgeries, and health promotion. Physical activity (PA) is an essential component of many chronic disease and surgical treatment programs, but the potential benefits of PA in CD are poorly understood as there has been a paucity of research in CD. Identifying factors that influence PA participation and the extent and intensity regular PA has a therapeutic effect (i.e., inflammatory biomarkers, mucosal healing) on disease activity in CD is important for developing effective PA interventions that can be translated to practice. Therefore, the primary objective of this research proposal is to examine the complex behavioral and biological correlates of PA in CD. This project seeks to compare PA rates between adults with CD and healthy controls (Aim 1) and examine the psychosocial and clinical influences on self-report and device-measured PA (Aims 2 and 3) in CD. The central hypothesis is that adults with CD who report lower levels of self-efficacy engage in less device-measured PA and more sedentary behavior than the general population, and that the relationship between PA and disease outcomes varies by both volume and pattern of PA behavior and the aspect of disease activity measured. The public health significance of this study lies in its potential to develop an improved, theoretically sound understanding of PA behavior in CD and the relationship between PA and disease activity. These findings could potentially result in better designed, more effective PA programs for adults with CD that ultimately have the potential to reduce healthcare costs associated with adverse postoperative outcomes. My ultimate career goal is to lead a collaborative research team that bridges the gap between evidence-based PA interventions and the translation of this evidence into clinical and community practice in the context of CD. To better prepare myself for a career as an independent investigator, I am seeking training in 4 major areas: 1) rigorous research in the CD field, including familiarity with CD clinical patient care; 2) multidisciplinary collaboration with clinicians and scientists; 3) translational research, including clinical trial design, statistical methods, and interpretation of results for clinical application and future intervention development; and 4) professional development, including principles of scientific integrity and responsible conduct of research. Training in these areas is integral to completing the research aims and providing me with a solid foundation for a successful career as an independent researcher.

项目概要/摘要 克罗恩病 (CD) 在美国影响着超过 500,000 名 CD 患者，是一种慢性且独特的疾病 病情具有挑战性，需要终身服药、进行大手术和促进健康。 (PA) 是许多慢性疾病和手术治疗计划的重要组成部分，但潜在的 由于缺乏关于 CD 识别因素的研究，人们对 PA 在 CD 中的益处知之甚少。 影响 PA 参与以及常规 PA 具有治疗作用的程度和强度（即炎症 生物标志物、粘膜愈合）对 CD 疾病活动的影响对于制定有效的 PA 干预措施非常重要 因此，本研究计划的主要目的是检验 CD 中 PA 的复杂行为和生物学相关性该项目旨在比较不同疾病之间的 PA 发生率。 患有 CD 的成年人和健康对照者（目标 1），并检查自我报告的心理社会和临床影响 和设备测量的 CD 中的 PA（目标 2 和 3） 中心假设是患有 CD 的成人报告较低。 与一般水平相比，自我效能水平涉及较少的设备测量 PA 和更多的久坐行为 人口，并且 PA 与疾病结果之间的关系因 PA 的数量和模式而异 PA 行为和测量的疾病活动方面。这项研究的公共卫生意义在于其。 对 CD 中的 PA 行为及其关系有更好的、理论上合理的理解的潜力 PA 与疾病活动之间的关系可能会导致 PA 设计得更好、更有效。 针对患有 CD 的成人的计划最终有可能降低与不良反应相关的医疗费用 我的最终职业目标是领导一个协作研究团队来弥合差距。 基于证据的 PA 干预措施与将证据转化为临床和社区之间的关系 为了更好地为独立调查员的职业生涯做好准备，我正在寻求 CD 背景下的实践。 4个主要领域的培训：1）在CD领域进行严格的研究，包括熟悉CD临床患者护理； 2）与信徒和科学家的多学科合作；3）转化研究，包括临床试验 临床应用和未来干预的设计、统计方法和结果解释 发展；4) 专业发展，包括科学诚信和负责任行为的原则 这些领域的培训对于完成研究目标和为我提供坚实的基础是不可或缺的。 为独立研究员的成功职业生涯奠定基础。