Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0

亚裔美国人、夏威夷原住民和太平洋岛民研究与教育 (CARE) 2.0 合作方法

基本信息

批准号：
10740342
负责人：
Joshua Grill
金额：
$ 322.24万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10740342
关键词：
Acceleration Achievement Adult Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Asian Americans Asian Indian Asian population Attitude Behavioral Biological Biological Markers Blood Budgets Caregivers Clinical Research Clinical Trials Communities Data Analyses Data Set Databases Education Effectiveness Elderly Eligibility Determination Enrollment Ensure Equity Ethnic Origin Filipino Focus Groups Funding Hawaiian Health Heterogeneity Image Individual Japanese Koreans Language Learning Life Style Modification Lightning Limited English Proficiency Methods Modality Multilingualism Native Hawaiian Native Hawaiian or Other Pacific Islander Outcome Pacific Islander Participant Pattern Persons Population Positioning Attribute Procedures R24 Recommendation Registries Reporting Research Research Design Risk Factors Samoan Sampling Source Structure Subgroup Testing Therapeutic Underrepresented Populations United States United States National Institutes of Health Vietnamese caregiving caregiving research cohort collaborative approach comparative dementia caregiving dementia risk effectiveness evaluation experience health disparity improved innovation interest outreach prospective racial population recruit recruitment science retention rate screening secondary analysis social culture socioeconomics tool willingness

项目摘要

Project Summary/Abstract of CARE 2.0 Despite being the fastest growing racial population in the United States, Asian American, Native Hawaiian, and Pacific Islander (AANHPI) persons remain severely underrepresented in research. For example, less than 3% of participants in the National Alzheimer's Coordinating Center database are AANHPI individuals and even fewer are enrolled in clinical trials of promising therapeutics. The Collaborative Approach for Research and Education (CARE) registry (R24 AG063718) is a US multi-lingual registry built to improve AANHPI representation in Alzheimer’s disease and related dementias (ADRD), aging, and caregiving research. Launched in October 2020, CARE has enrolled 9,405 AANHPI adults (as of 10/2/22) including 55.9% with limited English proficiency and 80.9% with no prior research participation experience. CARE has referred more than >5,500 participants to 27 studies that are in various stages of recruitment and study completion. As a critical next step and guided by the NIA health disparities framework, we propose CARE 2.0 to strategically expand the registry, advance the science of recruitment and retention of AANHPI participants, and examine the factors associated with research enrollment decisions among referred registry participants. Our specific aims include: 1) Examine attitudes toward health research in a diverse cohort of 10,000 newly recruited AANHPI adults in the US; 2) Elicit perspectives and recommendations from CARE participants about registry retention, and develop, implement, and evaluate recommended registry retention strategies. The Lightning Report Method will be used to conduct dynamic qualitative data analysis and rapid synthesis of the findings to allow rapid comparative analyses across groups and contexts to derive targeted strategies that are sensitive to the diverse needs of retaining AANHPI participants; and 3) Optimize CARE registry participants’ inclusion in NIA- funded and other aging studies and examine factors including study- and participant-level factors associated with participation in research. These innovative aims will increase and test the value of the CARE registry and inform the field more broadly on how best to increase representation of AANHPI groups in research. CARE is well-positioned to complete these aims and contribute to the growing science of recruitment and retention. This proposed application is responsive to PAR-22-093 (Research on Current Topics in ADRD) and NOT-AG-21-033 (Notice of Special Interest: Health Disparities and AD).

CARE 2.0 项目概要/摘要尽管亚裔美国人是美国人口增长最快的种族，夏威夷原住民和太平洋岛民 (AANHPI) 的代表性仍然严重不足例如，国家阿尔茨海默病协调中心的参与者不到 3%。中心数据库是 AANHPI 个体，参加临床试验的人更少研究和教育合作方法（CARE）。注册中心 (R24 AG063718) 是一个美国多语言注册中心，旨在提高 AANHPI 代表性从事阿尔茨海默病和相关痴呆症 (ADRD)、衰老和护理研究。 CARE 于 2020 年 10 月推出，已招募了 9,405 名 AANHPI 成年人（截至 22 年 10 月 2 日），其中包括 55.9% 的人英语水平有限，80.9% 的人之前没有参与过研究 CARE 已将超过 5,500 名参与者转介至不同领域的 27 项研究。作为下一步关键的招募和研究完成阶段，并由 NIA 卫生部门指导。差异框架，我们提出 CARE 2.0 来战略性地扩大登记范围，推进 AANHPI 参与者招募和保留的科学，并检查因素与所推荐的注册中心之间的研究注册决策相关。目标包括： 1) 检查 10,000 名不同人群对健康研究的态度在美国招募 AANHPI 成年人；2) 征求 CARE 的观点和建议；关于注册表保留，以及制定、实施和评估建议将使用闪电报告方法进行动态注册保留策略。定性数据分析和快速综合研究结果，以便进行快速比较分析跨群体和背景，以制定对不同需求敏感的有针对性的策略保留 AANHPI 参与者；以及 3) 优化 CARE 注册参与者纳入 NIA- 资助的和其他老龄化研究，并检查包括研究和参与者水平在内的因素与参与研究相关的因素将增加并受到考验。 CARE 注册表的价值，并更广泛地告知该领域如何最好地增加 AANHPI 团体在研究中的代表性能够很好地完成这些目标。并为不断发展的招聘和保留科学做出贡献。响应 PAR-22-093（ADRD 当前主题研究）和 NOT-AG-21-033（通知特别感兴趣：健康差异和AD）。