Training in Translational ADRD Neuroscience (TITAN)

转化 ADRD 神经科学培训 (TITAN)

• 批准号: 10475713
• 负责人: Joshua Grill
• 金额: $ 35.92万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475713
• 关键词: Alzheimer' s disease related dementia; Neurosciences; Training

Project Summary/Abstract Population aging is leading to a public health crisis in the growing number of people affected by Alzheimer’s disease (AD) and Related Dementias (ADRD). It has been more than 15 years since the last FDA approval for a new treatment for ADRD. To continue the dramatic progress over the last decade in understanding ADRD pathophysiology we will require significant preclinical and clinical translational research to bring candidate therapies to clinical use and grow a therapeutic armamentarium sufficient to curb the public health impact of ADRD. Essential to this success will be a new generation of ADRD scientists, especially scientists with the unique training and skills necessary to design and perform translational research. This training is rarely provided through the traditional course of medical, clinical psychology, basic science, or biostatistical education. As a result, there is a dearth of well-trained ADRD translational investigators. Moreover, there is inadequate diversity among the current group of active ADRD translational investigators, limiting the unique perspectives and team science synergies that could propel the field toward critical solutions. We propose here a new training program in translational ADRD research titled “Training in Translational ADRD Neuroscience (TITAN)” at the University of California, Irvine (UCI). This new training program will be broadly inclusive of promising graduate students and junior translational scientists, such as medical doctors, clinical psychologists, epidemiologists, biostatisticians, bioethicists, and neuroscientists. We have assembled an outstanding and similarly diverse team of preceptors who will ensure the success of this new training program. The program will develop novel training opportunities in ADRD translational research while also leveraging the considerable scientific and training resources at UCI, including the NIA P30-funded Alzheimer’s Disease Research Center (ADRC), which since April 2020 includes a Research Education Component with complementary objectives. Similarly, the UCI Institute for Clinical and Translational Science (ICTS) is UCI’s NCATS-funded CTSA program that offers synergistic training options to be leveraged, such as the K-club, responsible conduct of research workshops, and KL2 funding mechanisms. We will recruit diverse trainees from multidisciplinary specialties as well as individuals from nationally underrepresented racial and ethnic groups, individuals with disabilities, individuals from disadvantaged backgrounds, and women.

项目概要/摘要 人口老龄化正在导致越来越多的阿尔茨海默病患者面临公共卫生危机 疾病 (AD) 和相关痴呆症 (ADRD) 自 FDA 上次批准以来已经超过 15 年了。 ADRD 的新治疗方法 继续过去十年在理解 ADRD 方面的巨大进展。 病理生理学 我们将需要大量的临床前和临床转化研究来为候选者带来 临床使用的疗法并发展足以遏制公共卫生影响的治疗武器 ADRD 的成功至关重要的是新一代 ADRD 科学家，特别是具有 ADRD 能力的科学家。 设计和进行转化研究所需的独特培训和技能很少提供。 通过传统的医学、临床心理学、基础科学或生物统计教育课程。 结果，缺乏训练有素的 ADRD 转化研究人员，而且多样性不足。 目前活跃的 ADRD 转化研究人员中，限制了独特的视角和团队 科学协同作用可以推动该领域走向关键解决方案。 我们在此提出一项新的转化型 ADRD 研究培训计划，名为“转化型 ADRD 培训” 加州大学欧文分校 (UCI) 的神经科学 (TITAN)”这一新培训计划将广泛开展。 包括有前途的研究生和初级转化科学家，例如医生、临床医生 我们聚集了心理学家、流行病学家、生物统计学家、生物伦理学家和神经科学家。 杰出且同样多元化的导师团队将确保这一新培训计划的成功。 该计划将开发 ADRD 转化研究方面的新型培训机会，同时也利用 UCI 拥有大量科学和培训资源，包括 NIA P30 资助的阿尔茨海默病项目 研究中心 (ADRC)，自 2020 年 4 月起包括一个研究教育部分 同样，UCI 临床和转化科学研究所 (ICTS) 是 UCI 的互补目标。 NCATS 资助的 CTSA 计划提供可利用的协同培训选项，例如 K 俱乐部、 负责任地开展研究研讨会和 KL2 资助机制，我们将从中招募不同的学员。 多学科专业以及来自全国代表性不足的种族和族裔群体的个人， 残疾人、弱势群体和妇女。