Program in Recovery and Restoration of CNS Health and Function

中枢神经系统健康和功能的恢复和恢复计划

• 批准号: 10628694
• 负责人: LEIGH R HOCHBERG
• 金额: $ 37.42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628694
• 关键词: Health; Recovery; programs; restoration

Project Summary We seek renewed support for our highly productive postdoctoral Training program in Recovery and Restoration of CNS Health and Function following acute injury. The launch of this program has coincided with rapid growth in the investigation of neurorecovery nationally and internationally. Locally, this training program has been at the center of a substantial expansion of clinical, translational, and research activities in neurorecovery, including the launch of an innovative clinical fellowship and recruitment of several new research faculty. Furthermore, the program has successfully recruited participants in addition to those supported directly through this mechanism, enriching the training experience for faculty and postdoctoral fellows. The overall goals of the Training program in Recovery and Restoration of CNS Health and Function remain to provide essential research training to clinician-scientists, neuroengineers, and computational neuroscientists who can then go on to produce and apply discoveries that can restore function to patients who survive disabling brain injuries. To harness both local and national opportunities for our trainees, we have redesigned the program to create a more focused environment, anchored in the rich ecosystem of Massachusetts General Hospital and Spaulding Rehabilitation Hospital. The Center for Neurotechnology and Neurorecovery will serve as home base for all fellows. We have recruited a distinguished biostatistician to serve on our faculty and executive committee who will oversee a rigorous curriculum in experimental design, statistics, quantitative literacy and approaches. This curriculum will be part of a formal weekly seminar program that we have constructed explicitly for our program trainees. In addition, we have designed a career development curriculum to provide trainees with essential skills in communication, grant-writing, diversity and inclusion, and all other aspects of career development. Recruitment will focus on diversity, including those with disabilities, women and trainees from backgrounds underrepresented in medicine and engineering. Leveraging MGH’s substantial investment in Equity, Diversity and Inclusion, we have integrated this expertise into the Executive Committee, Faculty, and Advisory Committee. The program will continue active participation by an accomplished, multidisciplinary faculty drawn from anesthesia, engineering, computational neuroscience, neurology, neurosurgery, physical medicine and rehabilitation, psychiatry, and radiology. Mentors and research experiences will cover four themes: 1) Clinical Research and Clinical Trials, 2) Computational Neuroscience, 3) From Neural Recording to Neural Imaging, 4) Neural Repair and Neuromodulation. Support is requested for 4 post-doctoral trainees per year, each of whom will be supported for 2 years. Trainees will spend a minimum of 2 years in the program. The program will combine a mentored research project within one of the theme areas with specific coursework tailored to the theme area chosen by the trainee.

项目概要 我们寻求对我们高产的恢复和康复博士后培训项目的新支持 急性损伤后中枢神经系统健康和功能的恢复 该计划的启动恰逢其时。 随着国内和国际上神经恢复研究的快速发展，这种培训。 该计划一直是临床、转化和研究活动大幅扩展的中心 在神经恢复方面，包括启动创新的临床研究金和招募几名新的 此外，该计划还成功招募了除以下人员之外的参与者 通过该机制直接支持，丰富教师和博士后的培养经验 中枢神经系统健康恢复和恢复培训计划的总体目标 其功能仍然是为临床科学家、神经工程师和临床医生提供必要的研究培训 计算神经科学家可以继续产生并应用可以恢复的发现 为脑损伤后幸存的患者提供帮助 利用当地和国家的机会。 对于我们的学员，我们重新设计了该计划，以创造一个更加集中的环境，扎根于 马萨诸塞州总医院和斯波尔丁康复医院的丰富生态系统。 神经技术和神经恢复将作为所有研究员的大本营。 杰出的生物统计学家将在我们的教职员工和执行委员会中任职，他们将监督严格的 实验设计、统计学、定量素养和方法的课程。 这是我们为项目学员明确构建的正式每周研讨会计划的一部分。 此外，我们还设计了职业发展课程，为学员提供以下方面的基本技能： 沟通、资助写作、多样性和包容性以及职业发展的所有其他方面。 招聘将注重多元化，包括残疾人、女性和有背景的学员 利用 MGH 对股权的大量投资， 多元化和包容性，我们已将这些专业知识融入执行委员会、教职员工和 该计划将继续由多学科多才多艺的人士积极参与。 教师来自麻醉、工程学、计算神经科学、神经病学、神经外科、 物理医学和康复、精神病学和放射学将提供导师和研究经验。 涵盖四个主题：1）临床研究和临床试验，2）计算神经科学，3）来自 神经记录到神经成像，4) 需要 4 的神经修复和神经调节支持。 每年招收博士后实习生，每人将获得资助2年。 该计划将在其中一项中结合指导研究项目至少 2 年。 主题领域以及针对受训者选择的主题领域量身定制的具体课程。

项目成果

Cerebral Microvascular Injury in Severe COVID-19.

严重 COVID-19 中的脑微血管损伤。

• 发表时间: 2020-07-24
• 作者: Conklin, John;Frosch, Matthew P;Mukerji, Shibani;Rapalino, Otto;Maher, Mary;Schaefer, Pamela W;Lev, Michael H;Gonzalez, Ramon G;Das, Sudeshna;Champion, Samantha N;Magdamo, Colin;Sen, Pritha;Harrold, George Kyle;Alabsi, Haitham;Normandin, Eri
• 通讯作者: Normandin, Eri

COVID-19 Outpatient Screening: a Prediction Score for Adverse Events.

COVID-19 门诊筛查：不良事件的预测评分。

• 发表时间: 2020-06-22
• 作者: Sun, Haoqi;Jain, Aayushee;Leone, Michael J;Alabsi, Haitham S;Brenner, Laura;Ye, Elissa;Ge, Wendong;Shao, Yu;Boutros, Christine;Wang, Ruopeng;Tesh, Ryan;Magdamo, Colin;Collens, Sarah I;Ganglberger, Wolfgang;Bassett, Ingrid V;Meigs, Jame
• 通讯作者: Meigs, Jame

Differential patterns of default mode network activity associated with negative and positive rumination in bipolar disorder.

与双相情感障碍的消极和积极思考相关的默认模式网络活动的差异模式。

• DOI: 10.1016/j.jad.2022.12.014
• 发表时间: 2022-12-01
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: S. Ghaznavi;Tina Chou;Darin D. Dougherty;A. Nierenberg
• 通讯作者: A. Nierenberg

Emerging Consciousness at a Clinical Crossroads.

临床十字路口的新兴意识。

• 发表时间: 2021-04
• 作者: Young, Michael J;Edlow, Brian L
• 通讯作者: Edlow, Brian L

Fast inference of spinal neuromodulation for motor control using amortized neural networks.

使用摊销神经网络快速推断用于运动控制的脊髓神经调节。

• 发表时间: 2022-10-18
• 作者: Govindarajan, Lakshmi Narasimhan;Calvert, Jonathan S;Parker, Samuel R;Jung, Minju;Darie, Radu;Miranda, Priyanka;Shaaya, Elias;Borton, David A;Serre, Thomas
• 通讯作者: Serre, Thomas