Exercising language: Behavioral and neurophysiological changes after high-intensity exercise training in post-stroke aphasia.

运动语言：中风后失语症高强度运动训练后的行为和神经生理变化。

基本信息

批准号：
10862024
负责人：
Maria V. Ivanova
金额：
$ 71.25万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10862024
关键词：
Adjuvant Aerobic Affect Aftercare Anxiety Aphasia Attention Behavioral Blood Blood Vessels Blood flow Brain Cerebrovascular Circulation Cerebrum Chronic Clinical Cognition Cognitive Comprehension Dose Effectiveness Emotional Evaluation Exercise Family Friends Gait Health Health Benefit Individual Intervention Knowledge Language Language Disorders Language Therapy Lead Learning Life Maintenance Measures Mediating Memory Mental Depression Motor Motor Skills Names Neuronal Plasticity Outcome Outcome Measure Participant Patients Pattern Performance Perfusion Personal Satisfaction Persons Physical Exercise Physical Fitness Physiological Population Production Quality of life Recovery Speech Stroke Thinking Treatment Protocols Up-Regulation Vascular blood supply Well in self Work aphasia recovery behavioral outcome brain health cardiorespiratory fitness cerebrovascular cognitive ability cognitive benefits cognitive enhancement cognitive performance cost efficient design executive function exercise intensity exercise intervention exercise program exercise training fitness improved innovation insight language outcome motor recovery nervous system disorder neural neuroimaging neurophysiology neurovascular novel novel strategies physical conditioning post intervention programs psychologic psychosocial recruit response skills sleep quality social engagement stroke survivor stroke-induced aphasia tool traditional therapy

项目摘要

Project Summary/Abstract Losing the ability to speak and understand language is devastating for patients with aphasia and their families, negatively impacting multiple aspects of life and emotional well-being. Unfortunately, individuals with aphasia rarely regain their language skills in full. Novel approaches are required that boost the effects of traditional therapies, leading to better outcomes for people with aphasia. The proposed study seeks to evaluate the effects of a promising adjuvant intervention - physical exercise training - on recovery in aphasia. A new exercise program, specifically designed for individuals with post-stroke aphasia, will be the means of providing a safe, stroke- and aphasia-friendly physical exercise intervention to achieve optimal physical fitness gains. This will also be the first large scale study in aphasia to systematically examine the additive and enhancing effects of combining physical exercise training with traditional language therapy. Innovative outcome measures will include not only language and cognitive measures but also measures of motor skills and psychological and psychosocial outcomes that will assess the benefits of physical exercise. Another cutting-edge aspect of the study is the inclusion of advanced physiological fitness measures and neuroimaging metrics of blood flow and cerebrovascular reactivity as outcome measures to afford a deeper understanding of the exercise-mediated behavioral and neural effects in stroke survivors. We will recruit 110 individuals with aphasia to evaluate the multifaceted impact of exercise on behavioral and physical outcomes in isolation and in combination with traditional speech-language therapy. First, the benefits of physical exercise for language, cognition, motor, and emotional and psychological well-being in individuals with aphasia will be established. Of particular importance will be an enhanced understanding of how exercise can boost the effects of existing speech-language therapies. Second, determining how exercise-induced changes in physical fitness are related to changes in language and cognitive measures will provide insight into key ingredients of successful exercise interventions. Third, evaluation of the exercise-induced neurovascular changes that relate to behavioral improvements, as measured with novel blood supply neuroimaging tools, will advance our knowledge about the brain mechanisms of the observed cognitive benefits. Finally, the validated physical exercise intervention, resulting from this project, will offer a new tool to clinicians seeking to help individuals with aphasia, either as a free-standing program to enhance physical health, cognition, and well-being, or as an adjunct therapy to standard speech-language therapy. Ultimately, this work could significantly alter our thinking about adjuvant aphasia therapies that can benefit those affected by stroke and aphasia through non- traditional means, in this case, a promising, safe, and cost-efficient adjunct intervention that can enhance all levels of functioning from general health to language to social engagement.

项目概要/摘要失去说话和理解语言的能力对于失语症患者及其家人来说是毁灭性的家庭，对生活和情感健康的多个方面产生负面影响。不幸的是，个人失语症很少能完全恢复语言能力。需要新的方法来增强效果传统疗法可为失语症患者带来更好的结果。拟议的研究旨在评估一种有前景的辅助干预措施——体育锻炼的效果失语症康复培训。专为中风后患者设计的新锻炼计划失语症，将成为为中风和失语症患者提供安全、有利于中风和失语症的体育锻炼干预的方法实现最佳的身体健康收益。这也将是第一个大规模系统性失语症研究检验体育锻炼与传统语言相结合的叠加和增强效果治疗。创新的结果测量不仅包括语言和认知测量，还包括测量运动技能以及心理和社会心理结果将评估体育锻炼的益处。该研究的另一个前沿方面是纳入了先进的生理健康措施和血流和脑血管反应性的神经影像学指标作为结果测量，以提供更深入的研究了解运动介导的中风幸存者的行为和神经效应。我们将招募 110 名失语症患者来评估运动对行为的多方面影响以及单独和与传统言语治疗相结合的身体结果。首先，体育锻炼对语言、认知、运动、情感和心理健康的益处将建立失语症个体。特别重要的是加深对如何锻炼可以增强现有言语疗法的效果。二、确定运动诱发的方式身体健康的变化与语言的变化有关，认知测量将提供洞察力成功运动干预的关键要素。三、运动诱发神经血管的评估通过新型血液供应神经成像工具测量，与行为改善相关的变化将增进我们对观察到的认知益处的大脑机制的了解。最后，经过验证该项目产生的体育锻炼干预将为寻求帮助的临床医生提供一种新工具失语症患者，或者作为一个独立的项目来增强身体健康、认知和福祉，或作为标准言语治疗的辅助治疗。最终，这项工作可能会显着改变我们的思考失语症辅助疗法可以通过非非治疗手段使中风和失语症患者受益。在这种情况下，传统手段是一种有前途、安全且具有成本效益的辅助干预措施，可以增强所有从总体健康到语言再到社会参与的功能水平。