PROSPECTIVE STUDY OF DIET AND COLORECTAL ADENOMAS

饮食与结直肠腺瘤的前瞻性研究

• 批准号: 3423231
• 负责人: Walter C. Willett
• 金额: $ 3.58万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3423231
• 关键词: adenoma; alcoholic beverage consumption; body weight; cancer risk; carotenoids; dietary calcium; dietary fiber; dietary lipid; endoscopy; exercise; gastrointestinal imaging /visualization; human subject; longitudinal human study; neoplasm /cancer diagnosis; nutrition related neoplasm /cancer; nutrition related tag; questionnaires; retinoids; tobacco abuse; tocopherols

We propose to study prospectively the dietary etiologies of colorectal adenomas, precursors of the vast majority of colorectal cancers, in men and women from two large established cohorts, the Nurses' Health Study and the Health Professionals Follow-up Study. Participants in these studies (90,000 women and 52,000 men) have already completed a mailed self-administered semiquantititative food frequency questionnaire in 1986. The questionnaire has been intensively validated in subgroups of both cohorts. The cohort members report newly diagnosed diseases (including colon polyps) on mailed questionnaires every two years. The proposed study population will be restricted to subjects from both cohorts who have colonoscopy or sigmoidoscopy between 1986 and 1990, and will exclude persons who reported polyps before 1986. Cases are subjects with a first diagnosis of colorectal adenoma between 1986 and 1990, and non-cases are defined as subjects who had a endoscopic procedure negative for adenomas in the same time interval. We propose to obtain pathology reports to confirm the diagnosis of adenoma for all cases. We will also validate the pathologic diagnoses by reviewing a sample of the microscopic slides. Using nutrient intakes estimated from the 1986 dietary questionnaires, we plan to test the following hypotheses: high fiber intake reduces the risk and high fat intake increases the risk of developing colorectal adenomas. Other nutrients of interest that we will study are calcium, vitamins C and E, preformed vitamin, A, carotenoids and alcohol intake. We also have information on cigarette smoking, weight and height, exercise, and family history of colorectal cancer. Stratified and multivariate techniques will be used to quantify the age-adjusted relative risk of colorectal adenoma according to level of nutrient intake after controlling for other potentially important confounders. We project that 900 incident cases will be confirmed; this will provide 99% power to detect a relative risk of 1.5 between the high and low quintiles of specific nutrient intakes.

我们建议前瞻性地研究结直肠的饮食病因 腺瘤，绝大多数结直肠癌的前体，男性 以及来自两个大型成立队列的妇女，护士的健康研究 以及卫生专业人员的后续研究。 这些参与者 研究（90,000名女性和52,000名男性）已经完成了邮寄 自我管理的半定量食品频率问卷 1986年。问卷已在 两个队列。 队列成员报告了新诊断的疾病 （包括结肠息肉）每两年邮寄一次邮寄问卷。 这 拟议的研究人群将仅限于两者的受试者 1986年至1990年之间进行结肠镜检查或乙状结肠镜检查的同类群 将排除1986年之前报告息肉的人。病例是 在1986年至 1990年，非案例被定义为具有内镜的受试者 在同一时间间隔内腺瘤的过程为阴性。 我们建议 获得病理报告以确认所有人的腺瘤诊断 案例。我们还将通过审查A来验证病理诊断 微观载玻片的样品。 使用估计的营养摄入 1986年的饮食问卷，我们计划测试以下 假设：高纤维摄入量降低了风险和高脂肪的摄入量 增加了出现结直肠腺瘤的风险。 其他营养 我们将研究的感兴趣的是钙，维生素C和E，已预先形成 维生素，A，类胡萝卜素和酒精摄入量。 我们也有有关 吸烟，体重和身高，运动和家族史 结直肠癌。 将使用分层和多元技术 量化结直肠腺瘤的年龄调整后的相对风险 根据控制其他的养分摄入水平 潜在的重要混杂因素。 我们预测900例事件案件 将被确认；这将提供99％的功率来检测相对风险 特定营养摄入量的高分子和低分子之间的1.5。