Animal Models Core

动物模型核心

基本信息

批准号：
10628214
负责人：
MYRON E HINSDALE
金额：
$ 13.84万
依托单位：
OKLAHOMA STATE UNIVERSITY STILLWATER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-05 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628214
关键词：
Address Animal Experiments Animal Model Animal Welfare Animals Antiviral Agents Applications Grants Breeding COVID-19 pandemic COVID-19 vaccine Centers of Research Excellence Collaborations Communicable Diseases Communities Contracts Coronavirus Discipline Documentation Ensure Equipment Extramural Activities Faculty Fee-for-Service Plans Fostering Foundations Funding Genotype Goals Hand functions Housing IACUC Immunology Industry Infection Infectious Diseases Research Infrastructure Institution Instruction Knock-in Knock-out Letters Medical Research Mission Modeling Mycobacterium tuberculosis Oklahoma Phase Phenotype Pilot Projects Productivity Protocols documentation Qualifying Regulation Research Research Personnel Research Project Grants Respiratory Center Respiratory Disease Respiratory Function Tests Schedule Services Technology Training Transgenic Animals Universities Vaccines Viral Viral Pathogenesis Work base biosafety level 3 facility emerging pathogen industry partner infectious disease model interdisciplinary collaboration member pathogen pre-clinical programs prospective research clinical testing respiratory respiratory pathogen success virology

项目摘要

Animal Models Core Project Summary: Centers of Biomedical Research Excellence Phase I and II funding for the animal models core (AMC) established a research core with expertise in respiratory and infectious diseases, including state-of-the-art equipment and animal biosafety level 2 (ABSL-2) housing and procedural facilities. With Phase III the AMC will be expanding its services for the ABSL-2 studies with new cutting-edge equipment for phenotyping of animal models of respiratory and infectious disease. In addition, the AMC will be expanding its services to ABSL-3 animal models to better address the urgent needs for BSL3 research at the state level as well as the national level. The central objective of this Phase III proposal is to strengthen the existing BSL2 infrastructure and services and enhance the AMC with ABSL-3 capabilities to adapt to the expanding needs in respiratory and infectious disease research in Oklahoma. The aims of this proposal are: i) Aim 1: Provide a state-of-the-art ABSL-2/3 service to CoBRE pilot projects and other Oklahoma researchers; ii) Aim 2: Provide ABSL-2/3 experimental and regulatory training to CoBRE investigators; iii) Aim 3: Develop a sustainable and independent ABSL-2/3 AMC for use beyond Phase III funding. As a result of Phase III activities, the AMC will increase interdisciplinary interactions between and training of Oklahoma Center for Respiratory Infectious Disease (OCRID) researchers at Oklahoma State University, University of Oklahoma and Oklahoma Medical Research Foundation.

动物模型核心项目概要：生物医学研究卓越中心为动物模型核心（AMC）提供第一期和第二期资助建立了一个拥有呼吸系统和传染病专业知识的研究核心，包括最先进的设备和动物生物安全 2 级 (ABSL-2) 住房和程序设施。在第三阶段，AMC 将通过用于动物表型分析的新尖端设备扩大其对 ABSL-2 研究的服务呼吸道和传染病模型。此外，AMC 还将把其服务扩展到 ABSL-3 动物模型，以更好地解决州级和国家级 BSL3 研究的迫切需求等级。该第三阶段提案的中心目标是加强现有的 BSL2 基础设施和服务并通过 ABSL-3 能力增强 AMC，以适应呼吸和疾病领域不断扩大的需求俄克拉荷马州的传染病研究。该提案的目标是： i) 目标 1：提供最先进的 ABSL-2/3 为 CoBRE 试点项目和其他俄克拉荷马州研究人员提供服务； ii) 目标 2：提供 ABSL-2/3 对 CoBRE 研究人员进行实验和监管培训； iii) 目标 3：发展可持续的、独立的 ABSL-2/3 AMC，用于 III 期资金之外的用途。作为第三阶段活动的结果，AMC 将增加俄克拉荷马州呼吸道传染病中心之间的跨学科互动和培训俄克拉荷马州立大学、俄克拉荷马大学和俄克拉荷马医学院的疾病 (OCRID) 研究人员研究基金会。