Core 2: Data Science Core

核心 2：数据科学核心

• 批准号: 10629083
• 负责人: SUNGYONG YOU
• 金额: $ 24.2万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629083
• 关键词: Achievement; Address; Animal Experiments; Basic Science; Bioinformatics; Biological; Biometry; Chromosomes; Collaborations; Computational Technique; Computer Analysis; Computer software; Computers; Data; Data Analyses; Data Science; Data Science Core; Data Storage and Retrieval; Database Management Systems; Databases; Development; Ensure; Experimental Designs; Goals; Health Insurance Portability and Accountability Act; Immunity; Institutional Review Boards; Investigation; Malignant neoplasm of urinary bladder; Manuscripts; Methodology; Mining; Multiomic Data; Nature; Outcome; Participant; Pathology; Patients; Procedures; Program Research Project Grants; Randomized; Regulation; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Retrieval; Role; Sample Size; Specimen; Standardization; Structure; System; Testing; Translating; Translational Research; Visualization; Writing; analysis pipeline; anticancer research; central database; computerized data processing; computerized tools; data access; data analysis pipeline; data harmonization; data integration; data management; data quality; design; experimental study; laboratory experiment; mathematical model; member; multidisciplinary; preservation; programs; relational database; research study; sex

CORE 2, DATA SCIENCE – SUMMARY The purpose of the Data Science Core (Core 2) is to provide a comprehensive, multi-disciplinary resource with expertise in biostatistics and bioinformatics. Members of the Core 2 will collaborate closely with investigators from each project in translating their biological hypotheses into testable statistical hypotheses and address the corresponding aims at all levels of investigation. This consists of designing laboratory and animal experiments, storing and managing the resulting data, statistical and bioinformatics data analyses using well-established and pre-tested analysis pipelines, mining and integration of public data, and formulating new hypotheses based on discoveries arising from exploration and visualization of the integrated data. The Core 2 serves as a focal point from which investigators may be assisted with statistical and bioinformatics expertise for planning, management, and analysis of their studies. It also develops, tests, and implements various statistical and computational techniques, including mathematical modeling with special focus on cancer research. Types of research supported include basic science, translational research, and omics data analysis. The large volume of information to be generated in the proposed research projects and cores requires computer-guided approaches for coordination of efforts and management of data. The primary role of the Core 2 will include establishing a centralized relational database system and data management structure that facilitate entry, storage and retrieval of all data generated by the program projects and permits the controlled exchange of information across the projects and cores. De-identified information will be available to all investigators associated with this Program Project Grant (PPG). Due to the sensitive nature of the information stored by the Core 2, we will take extensive precautions to protect the confidentiality of participants. All IRB and HIPAA regulations will be strictly enforced. By providing data access to investigators, sharing technical capabilities, and ensuring the quality of the data, the data management component of this core will facilitate achievement of the project aims and encourage exploratory analyses beyond those stated.

核心 2，数据科学 – 总结 数据科学核心（核心 2）的目的是提供全面的、多学科的资源 核心 2 成员将与研究人员密切合作。 每个项目将其生物学假设转化为可检验的统计假设并解决 各级调查的相应目标包括设计实验室和动物实验， 使用成熟和可靠的方法存储和管理结果数据、统计和生物信息学数据分析 预先测试的分析管道，公共数据的挖掘和整合，并在此基础上制定新的假设 综合数据的探索和可视化所产生的发现是核心 2 的焦点。 调查人员可以在规划方面获得统计和生物信息学专业知识的帮助， 它还开发、测试和实施各种统计和分析。 计算技术，包括特别关注癌症研究类型的数学建模。 支持的研究包括基础科学、转化研究和大量的组学数据分析。 拟议研究项目和核心中生成的信息需要计算机引导的方法 核心 2 的主要作用包括建立工作协调和数据管理。 集中式关系数据库系统和数据管理结构，方便录入、存储和 检索方案项目生成的所有数据并允许受控的信息交换 与此相关的所有调查人员都将可以获得跨项目和核心的去识别化信息。 计划项目资助 (PPG) 由于 Core 2 存储的信息的敏感性，我们将 采取广泛的预防措施来保护参与者的机密。所有 IRB 和 HIPAA 法规都将得到遵守。 通过向调查人员提供数据访问、技术共享能力并确保质量来严格执行。 的数据，该核心的数据管理部分将有助于实现项目目标和 鼓励超出规定的探索性分析。