Huntsman Cancer Institute (HCI) Cancer Genetics, Epigenetics, Models, and Signaling (Cancer GEMS) Training Program

亨斯迈癌症研究所 (HCI) 癌症遗传学、表观遗传学、模型和信号传导（癌症 GEMS）培训计划

• 批准号: 10627604
• 负责人: Donald E Ayer
• 金额: $ 19.69万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627604
• 关键词: Epigenetic Process; Malignant Neoplasms; Modeling; Signal Transduction; Training Programs; cancer genetics

PROJECT SUMMARY We propose the Huntsman Cancer Institute (HCI) Cancer Genetics, Epigenetics, Models, and Signaling (Cancer GEMS) Training Program. HCI is a National Cancer Institute-designated Comprehensive Cancer Center and the official Cancer Center of the State of Utah. Contributing to HCI’s mission of reducing morbidity and mortality from cancer, GEMS provides a robust two-year predoctoral training program that leverages HCI research strengths in cancer genetics and epigenetics, cancer modeling, and cancer cell signaling, plus integrates trainee interactions with cancer patients, cancer clinicians, and our Disease Centers, to provide broad multidisciplinary training in cancer biology. The program goal is to prepare young scientists who are broadly trained in cancer biology and well-versed in multidisciplinary research approaches for impactful and rewarding opportunities in cancer-focused post-doctoral fellowships or other cancer-related research-intensive career paths. We have carefully selected 28 experienced HCI members to serve as training faculty, with an additional 12 promising junior faculty as associate mentors. The GEMS program will support six predoctoral candidates per year. Trainees will be recruited into mentor’s laboratories after entering the University of Utah (U of U) via graduate programs in Molecular Biology, Biological Chemistry, Public Health, and Population Health Science. The program will also recruit students from our MD-PhD program. These graduate programs recruit an average of 69 students annually, ensuring a deep pool of potential GEMS participants. GEMS trainees will be selected based on their academic performance, promise as cancer researchers, and commitment to transdisciplinary cancer training. Training in the GEMS program includes courses in basic and clinical cancer biology and cancer-focused electives. To complement these didactic courses, our trainees will have multiple opportunities to understand cancer from a clinical and patient-centric perspective. These opportunities include broad exposure to cancer as a disease, including interactions with patients, exposure to different operational units within HCI, physician shadowing, and attendance at Treatment Planning Conferences. These activities are buttressed by Research-In-Progress presentations, a career development series, and participation at an annual GEMS trainee retreat. The GEMS program is strengthened by optional training activities, including a Master of Science in Clinical Investigation and a certificate in Genome Sciences. GEMS trainees will receive experimental and career development advice, the latter guided by required Individual Development Plans, from their mentor and their thesis committee. The GEMS leadership team will receive guidance from an External Advisory Committee comprised of leaders of successful NCI T32 programs and a Steering Committee comprised of U of U education leaders. We will use professional evaluation tools to ensure the effectiveness of the GEMS program, and we will track trainees following completion of the program.

项目概要 我们建议亨斯曼癌症研究所 (HCI) 癌症遗传学、表观遗传学、模型和信号转导 （癌症 GEMS）培训计划是美国国家癌症研究所指定的综合癌症培训计划。 中心和犹他州官方癌症中心为 HCI 降低发病率的使命做出贡献。 和癌症死亡率，GEMS 提供了一个强大的、利用 HCI 的为期两年的博士前培训计划 癌症遗传学和表观遗传学、癌症建模和癌细胞信号传导方面的研究优势，以及 整合学员与癌症患者、癌症信徒和我们的疾病中心的互动，以提供 该项目的目标是培养年轻科学家，使其成为癌症生物学方面的广泛的多学科培训。 接受过广泛的癌症生物学培训，精通多学科研究方法，以实现有影响力和 以癌症为重点的博士后奖学金或其他癌症相关研究密集型的奖励机会 我们精心挑选了 28 名经验丰富的 HCI 成员作为培训教师，拥有 另外 12 名有前途的初级教师作为副导师，GEMS 项目将支持 6 名博士生。 每年的候选人将在进入犹他大学后被招募到导师的实验室。 （U of U）通过分子生物学、生物化学、公共卫生和人口研究生课程 该项目还将招收我们的医学博士-博士项目的学生。 每年平均招收 69 名学生，确保有大量潜在的 GEMS 参与者。 将根据学员的学业成绩、作为癌症研究人员的承诺以及 致力于跨学科癌症培训。GEMS 计划的培训包括基础和癌症培训课程。 为了补充这些教学课程，我们的学员将学习临床癌症生物学和以癌症为重点的选修课。 有多种机会从临床和以患者为中心的角度了解癌症。 机会包括广泛接触癌症作为一种疾病，包括与患者的互动、接触 HCI 内的不同运营单位、医生跟踪以及参与治疗计划 这些活动得到正在进行的研究演示和职业发展的支持。 系列，并参加年度 GEMS 实习生静修会 通过可选项目加强了 GEMS 计划。 培训活动，包括临床研究理学硕士学位和基因组科学证书。 GEMS 学员将获得实验和职业发展建议，后者以所需的指导为指导 GEMS 领导团队将制定个人发展计划。 接受由成功的 NCI T32 项目领导者组成的外部咨询委员会的指导 由U of U教育领导组成的指导委员会我们将使用专业的评估工具来进行评估。 确保GEMS项目的有效性，我们将在项目完成后跟踪学员。