ENNCF - Viral Vector Core

ENNCF - 病毒载体核心

• 批准号: 9116317
• 负责人: KERRY J. RESSLER
• 金额: $ 18万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9116317
• 关键词: Collaborations; Consultations; Core Facility; Custom; Data; Data Analyses; Education; Educational workshop; Emerging Technologies; Environment; Experimental Designs; Faculty; Fostering; Funding; Gene Delivery; Generations; Genes; Goals; Group Meetings; Human Resources; In Vitro; Interdisciplinary Study; Lentivirus Vector; Methodology; Mission; National Institute of Neurological Disorders and Stroke; Neurosciences; Neurosciences Research; Recombinants; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Retroviral Vector; Serotyping; Training; Viral; Viral Vector; Virus; adeno-associated viral vector; base; design; design and construction; gene delivery system; in vivo; innovation; member; recombinant adenovirus; technique development; translational neuroscience; vector; web site

SUMMARY The mission of the Viral Vector Core is to pave the way for gene delivery in neuroscience research. The Viral Vector Core has become an important technological resource for all NINDS funded investigators at Emory. The primary objectives of the ENNCF Viral Vector Core are to provide: (1) access to state-of-the-art, high-titer, custom designed, 2nd and 3rd generation lentiviral vectors and retroviral vectors, as well as recombinant adenovirus-associated viral (rAAV) vectors of a variety of serotypes, including AAV serotypes 1, 2, 5, 9 and chimeric AAV1/2 vectors, (2) expertise and guidance in the design and construction of viral vectors, optimal use of all viral vectors in vitro and in vivo, guidance on the selection of appropriate viral based gene-delivery systems and trouble-shooting and interpretation of data with direct consultation with core director and personnel, and (3) an outstanding research environment that provides infrastructure, education and resources to foster collaborations between investigators and cores, as well as a resource for entry vectors used to generate lentiviral and rAAV vectors through fostering collaborations and interactions amongst investigators with similar research objectives, and through organization of data clubs and seminar presentations. This environment will facilitate interactions between researchers across labs, departments and centers and provide trainees and junior faculty members with additional opportunities for collaboration. These objectives, implemented by the Viral Vector Core, have proven to stimulate multidisciplinary research and innovation in basic and translational neuroscience.

概括 病毒载体核心的使命是为神经科学研究中的基因递送铺平道路。病毒 向量核心已成为Emory的所有NINDS资助的研究人员的重要技术资源。这 ENNCF病毒矢量核心的主要目标是提供：（1）访问最先进的高点， 定制设计，第二代和第三代慢病毒载体和逆转录病毒载体以及重组 各种血清型的腺病毒相关病毒（RAAV）载体，包括AAV血清型1、2、5、9和 嵌合AAV1/2向量，（2）病毒载体设计和构建的专业知识和指导，最佳 在体外和体内使用所有病毒载体 通过与核心董事直接咨询数据的系统和故障射击和解释数据 人员，以及（3）提供基础设施，教育和 促进调查人员与核心之间合作的资源，以及入门向量的资源 用于通过促进合作和互动来生成慢病毒和RAAV载体 具有类似研究目标的研究人员，以及通过组织俱乐部和研讨会的组织 演讲。这种环境将促进实验室，部门和部门之间的研究人员之间的互动 中心并为学员和初级教师提供其他合作机会。 这些目标是由病毒媒介核心实施的，已被证明可以刺激多学科研究 以及基本和转化神经科学的创新。