HAWAII CLINICAL RESEARCH NETWORK FOR HEALTH EQUITY

夏威夷健康公平临床研究网络

基本信息

批准号：
10631836
负责人：
Venkataraman Balaraman
金额：
$ 152.18万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-24 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10631836
关键词：
Address Adherence Age Cerebrovascular Disorders Chronic Kidney Failure Clinic Clinical Research Communities Data Databases Development Diabetes Mellitus Disease Disease Management Early Diagnosis Electronic Health Record Enrollment Ensure Ethnic group Fatty Liver Fatty acid glycerol esters Federally Qualified Health Center Filipino General Population Geography Goals Grant Guidelines HIV Hawaii Health Health Disparities Research Health system Homelessness Indigenous Infrastructure Institutional Review Boards Island Link Liver Liver Fibrosis Liver diseases Logistics Longevity Malignant neoplasm of lung Monitor Native Hawaiian Obesity Pacific Islander Pacific Ocean Patients Persons Phase Pilot Projects Policies Population Preparation Prevalence Primary Health Care Procedures Process Protocols documentation Public Health Registries Research Research Design Research Personnel Research Project Grants Risk Rural Community Secure Sexual and Gender Minorities System Translational Research Underinsured Uninsured Update Vulnerable Populations base chronic liver disease clinical research site comorbidity data enclave data repository elastography fatty liver disease gender minority group health care delivery health disparity health equity interest malignant breast neoplasm medically underserved population non-alcoholic fatty liver disease patient safety population based primary care setting racial diversity recruit

项目摘要

Project Summary/Abstract The overall goal of this application is to organize a local consortia of ambulatory primary care settings in Hawaii to form the Hawaii Clinical Research Network for Health Equity (HICRN-HE). The clinical research network will focus on the health disparity needs of the Indigenous Pacific People (IPP)–defined as Native Hawaiians, other Pacific Islanders, and Filipinos. The 2 largest health systems in Hawaii providing primary care to a substantial number of IPP [the Queen’s Health System (QHS) and Hawaii Pacific Health (HPH)] and Federally Qualified Health Centers on Oahu will be invited to join the HICRN-HE. The UG3 (first 2 years of the grant) phase will be devoted to developing the infrastructure for HICRN-HE. A secure analyzable and regularly updated patient data repository derived from electronic health records from QHS and HPH will be established to support database analyses of health disparity issues. A Clinical and Translational Research Registry will be created and maintained to link interested local researchers and their research capabilities with those seeking researchers for clinical research/trials. The HICRN-HE will develop a framework for monitoring the implementation phase of HICRN-HE clinical studies to ensure patient safety, adherence to study protocol, and ability to meet recruitment goals. The UH3 phase (years 3-5 of the grant) will be devoted to implementing 2 projects under the thematic health disparity problem of Non-Alcoholic Fatty Liver Disease (NAFLD). Project 1 will focus on NAFLD over the Lifespan in Hawaii and assess the prevalence, risk, co-morbidities, and age at onset of NAFLD in IPP. Project 2 will focus on rates and risks of NAFLD among our sexual and gender minority groups living with HIV to uncover the HIV-specific factors that may contribute to risk above and beyond those in the general population.

项目概要/摘要该应用程序的总体目标是组织夏威夷流动初级保健机构的当地联盟组建夏威夷健康公平临床研究网络 (HICRN-HE)。关注太平洋原住民 (IPP)（定义为夏威夷原住民、其他人）的健康差异需求夏威夷两个最大的卫生系统为太平洋岛民和菲律宾人提供初级保健。 IPP [女王健康系统 (QHS) 和夏威夷太平洋健康 (HPH)] 和联邦合格的数量欧胡岛的健康中心将受邀加入 HICRN-HE UG3（资助的前 2 年）阶段。致力于开发 HICRN-HE 的基础设施安全可分析且定期更新的患者。将建立源自 QHS 和 HPH 电子健康记录的数据存储库，以支持将创建健康差异问题的数据库分析。并保持将感兴趣的当地研究人员及其研究能力与寻求帮助的人联系起来 HICRN-HE 将开发一个监测框架。 HICRN-HE 临床研究的实施阶段，以确保患者安全、遵守研究方案，以及 UH3 阶段（拨款的第 3-5 年）将致力于实施 2 非酒精性脂肪性肝病 (NAFLD) 主题健康差异问题下的项目 1。将重点关注夏威夷人一生中的 NAFLD，并评估其患病率、风险、合并症和年龄 IPP 中 NAFLD 的发病率项目 2 将重点关注我们的性少数群体中 NAFLD 的发病率和风险。艾滋病毒感染者群体发现可能导致上述风险的艾滋病毒特定因素在一般人群中。