Developmental Neuroscience and Child Psychopathology

发育神经科学和儿童精神病理学

基本信息

批准号：
10625103
负责人：
Deanna Barch
金额：
$ 40.9万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10625103
关键词：
Child Development Neurosciences Psychopathology

项目摘要

Developmental neuroscience and psychopathology have great potential to inform the understanding of the causal pathways and mechanisms of mental illness. This T32, which is focused on this domain, is co-led by Drs. Luby and Barch (with complimentary expertise in developmental psychopathology and neuroscience), and has been very successful in the first two cycles of funding, enjoying a highly competitive national applicant pool and successfully launching the young scientists completing the program into research careers and external funding. We seek to renew this training grant, adding new expertise in a wider range of neuroimaging measures, as well as new faculty mentors with expertise in the effects of genetics, the gut microbiome, and sleep/circadian rhythms on neurodevelopment and risk for psychopathology. From a public health perspective, an infusion of new research scientists in the area of developmental neuroscience and psychopathology continues to be a high priority. The proposed multi-disciplinary training approach is guided by a conceptual model that recognizes that the risk, onset, and course of psychiatric disorders arises through a complex interplay of brain developmental processes influenced by environmental, psychosocial, cognitive, affective, genetic, and biological factors that interact beginning in utero and continue throughout development. Numerous investigators at Washington University in St. Louis (WUSTL) have a rich track record of experience in many aspects of child neuroimaging and related methods, including a focus on structural and functional magnetic resonance approaches in very early childhood (including neonates), functional near-infrared spectroscopy (fNIRS), evoked response potentials (ERP) and high density diffuse optical tomography (HD- DOT). Further, WUSTL has an international reputation in psychiatric genetics, gut microbiome work, and sleep/circadian rhythms, with many researchers who can bring their expertise to bear on understanding the neurobiology of developmental psychopathology. The program mentors have a rich body of available databases derived from longitudinal studies, several of which began in early childhood and in utero. Mentors also provide a unique multidisciplinary training environment in which to pursue this exciting domain focused on development, given the established collaborations between child researchers in the WUSTL School of Medicine clinical and basic departments, and the state of the program in neuroscience and neuroimaging at WUSTL that has been at the forefront of developmental cognitive and affective neuroscience. Interactions between researchers in basic and clinical developmental neuroscience offer an ongoing opportunity to help train the next generation of young scientists who can pursue questions about the developmental etiology of psychopathology from the perspective of core psychological and neural mechanisms of human behavior that span traditional boundaries of psychopathology, an approach central to the NIMH Research Domain Criteria Initiative (RDOC).

发展神经科学和精神病理学具有巨大的潜力来帮助理解精神疾病的因果途径和机制。这个专注于这个领域的T32由博士。卢比和巴奇（在发展精神病理学和神经科学方面拥有互补的专业知识），以及在前两轮资助中非常成功，享有高度竞争的全国申请者群体并成功地引导完成该计划的年轻科学家进入研究生涯和外部资金。我们寻求续签这项培训补助金，在更广泛的神经影像领域增加新的专业知识措施，以及在遗传学、肠道微生物组和疾病影响方面具有专业知识的新教师导师睡眠/昼夜节律对神经发育和精神病理学风险的影响。从公共卫生角度来看，发育神经科学和精神病理学领域新研究科学家的注入仍然是一个高度优先事项。拟议的多学科培训方法以概念为指导该模型认识到精神疾病的风险、发作和病程是通过复杂的过程产生的受环境、心理社会、认知、情感、遗传和生物因素从子宫内开始相互作用并在整个发育过程中持续存在。圣路易斯华盛顿大学 (WUSTL) 的众多研究人员拥有丰富的经验记录在儿童神经影像学和相关方法的许多方面，包括对结构和功能的关注幼儿期（包括新生儿）的磁共振方法、功能性近红外光谱 (fNIRS)、诱发反应电位 (ERP) 和高密度漫射光学断层扫描 (HD- 点）。此外，WUSTL 在精神遗传学、肠道微生物组工作和睡眠/昼夜节律，许多研究人员可以利用他们的专业知识来理解睡眠/昼夜节律发育精神病理学的神经生物学。该项目导师拥有丰富的可用资源数据库源自纵向研究，其中一些研究始于幼儿期和子宫内。导师还提供独特的多学科培训环境，在其中追求这个令人兴奋的领域，重点关注鉴于 WUSTL 学院儿童研究人员之间已建立的合作关系，医学临床和基础部门，以及神经科学和神经影像学项目的现状 WUSTL 一直处于发展认知和情感神经科学的前沿。互动基础和临床发育神经科学研究人员之间的合作提供了一个持续的机会来帮助培养下一代年轻科学家，他们可以研究有关发育病因学的问题精神病理学从人类行为的核心心理和神经机制的角度跨越精神病理学的传统界限，这是 NIMH 研究领域标准的核心方法倡议（RDOC）。

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Children's awareness of the context-appropriate nature of emotion regulation strategies across emotions.

儿童对跨情绪的情绪调节策略的上下文适当性质的认识。

DOI：
发表时间：
2020-08
期刊：
影响因子：
2.6
作者：
Quiñones;Davis, Elizabeth L
通讯作者：
Davis, Elizabeth L

Maternal borderline personality disorder symptoms and convergence between observed and reported infant negative emotional expressions.

母亲边缘性人格障碍症状以及观察到的和报告的婴儿负面情绪表达之间的趋同。

DOI：
发表时间：
2015-07
期刊：
影响因子：
0
作者：
Whalen DJ;Kiel EJ;Tull MT;Latzman RD;Gratz KL
通讯作者：
Gratz KL

Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis.

每日皮质醇斜率与身心健康结果：系统评价和荟萃分析。

DOI：
发表时间：
2017-09
期刊：
影响因子：
3.7
作者：
Adam, Emma K;Quinn, Meghan E;Tavernier, Royette;McQuillan, Mollie T;Dahlke, Katie A;Gilbert, Kirsten E
通讯作者：
Gilbert, Kirsten E

I don't want to come back down: Undoing versus maintaining of reward recovery in older adolescents.

我不想回到下面：在年龄较大的青少年中取消与维持奖励恢复。