The Developmental Psychopathology of Suicidal Ideations and Cognitions in Childhood

童年自杀意念和认知的发展精神病理学

基本信息

批准号：
10593936
负责人：
Deanna Barch
金额：
$ 62.47万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10593936
关键词：
11 year old 7 year old Accounting Adolescence Adolescent African American Age Award Behavior assessment Behavioral Bipolar Disorder Brain Case Study Cause of Death Centers for Disease Control and Prevention (U.S.)Cessation of life Characteristics Child Child Rearing Childhood Climacteric Cognition Corpus striatum structure Data Death Rate Depressed mood Development Early Intervention Early identification Event Event-Related Potentials Evolution Exhibits Family Family history of Feedback Feeling Feeling hopeless Feeling suicidal Frequencies Funding Guilt Hospitals Impulsivity Injury Investigation Life Literature Longitudinal Studies Maps Measures Mediating Mediator Mental Depression Methods Modeling National Institute of Mental Health Nursery Schools Pain Threshold Parents Preschool Child Prevalence Prevention Psychopathology Psychosocial Factor Publishing Recording of previous events Reporting Research Domain Criteria Rewards Risk Risk Factors Sampling School-Age Population Self-Injurious Behavior Severities Shame Stimulus Suicide Suicide attempt Testing Thinking Time Visit aged boys bullying design early adolescence early childhood early onset emotion dysregulation experience follow-up girls indexing longitudinal course middle childhood neural neural correlate non-suicidal self injury peer peer victimization prepuberty prospective protective factors psychologic psychosocial response risk sharing social suicidal suicidal behavior suicidal morbidity suicide rate

项目摘要

Abstract: A marked increase in suicidal thoughts and behaviors (STB) among pre-pubertal children over the last decade has been reported by the CDC. Death by suicide in children ages 10-14 more than doubled between 2007 and 2014 with rates of non-lethal self-inflicted injuries doubling during the same period. Despite these dramatic rises in STB rates, there has been little investigation of the prevalence, timing of onset, or correlates and causes of STB or non-suicidal self-injury (NSSI) in pre-pubertal children. In a longitudinal study of preschool depression, we reported that preschool-onset STB shows stability across childhood. Outside of case reports, there are no other published data on STB or NSSI in early childhood. Our findings, taken together with the CDC data, support the critical need for studies of STB and NSSI that start in early childhood to identify the predictors of STB and NSSI in middle childhood and adolescence. In a sample of 3-7 year olds screened for a treatment study of depression we again found alarmingly high rates of NSSI (21.3%) and STB (19.4%) at baseline. Supplemental NIMH funding was awarded to investigate the characteristics and neural and behavioral correlates of STB and NSSI in this depressed sample, and to add age matched healthy controls. We found both common and unique risk factors for STB and NSSI in young children, consistent with the extant adolescent literature. Building on these findings, we propose to follow this well characterized sample into school age and early adolescence to test developmental models of these phenomena. We will investigate the longitudinal course, mediators and moderators, and neural correlates of early onset STB and NSSI. We will conduct behavioral and ERP assessments at two time points, 18-months apart in our sample of N=314 who have data from the preschool period. We will also sample the frequency, intensity, and proximal precipitants of STB/NSSI using weekly mini-assessments (WMA). Building on preliminary findings, we will use ERPs to test hypotheses about RDoC constructs that map to the risk factors that may contribute to STB and NSSI, including responses to negative and positive feedback to reward, errors, and peer rejection. We will test specific hypotheses about both shared risk factors for NSSI and STB (greater depression, peer rejection, adverse life events, and harsh parenting, as well as stronger ERP responses to loss and peer rejection, and blunted ERP responses to wins and social acceptance) as well as risk factors that may be more selective for NSSI (greater shame, irritability, self-criticism and higher pain tolerance) versus STB (reduced belongingness, greater hopelessness and a family history of suicide). Given the young age of the ascertained sample at baseline, we also have the opportunity to investigate differences in risk as a function of developmental stage. The proposed study provides an unprecedented opportunity to follow the largest ever sample of young children with STB and NSSI to investigate developmental trajectories into school age and early adolescence, potentially identifying early developmental targets for earlier intervention.

摘要：青春期前儿童的自杀想法和行为（STB）显着增加。疾病预防控制中心（CDC）报告了过去十年的情况。 10-14岁儿童自杀死亡人数增加了一倍多 2007 年至 2014 年间，非致命性自伤发生率同期翻了一番。尽管尽管 STB 发病率急剧上升，但对患病率、发病时间或青春期前儿童 STB 或非自杀性自伤 (NSSI) 的相关性和原因。在一项纵向研究中对于学前抑郁症，我们报告说，学前发病的 STB 在整个童年时期表现出稳定性。之外病例报告中，没有关于幼儿期 STB 或 NSSI 的其他已发表数据。我们的发现与 CDC 数据一起，支持从幼儿期开始进行 STB 和 NSSI 研究的迫切需要确定儿童中期和青春期 STB 和 NSSI 的预测因素。以3-7岁儿童为样本在一项抑郁症治疗研究筛选中，我们再次发现 NSSI (21.3%) 和 STB 的发病率高得惊人 (19.4%) 为基线。 NIMH 提供补充资金用于研究特征和神经以及该抑郁样本中 STB 和 NSSI 的行为相关性，并添加年龄匹配的健康人群控制。我们发现幼儿中 STB 和 NSSI 的常见和独特危险因素，与现存的青少年文学。基于这些发现，我们建议遵循这个特征良好的样本进入学龄期和青春期早期来测试这些现象的发展模型。我们将调查早发性 STB 和 NSSI 的纵向过程、中介因素和调节因素以及神经相关因素。我们将在我们的 N=314 名样本中，相隔 18 个月的两个时间点进行行为和 ERP 评估有学龄前时期的数据。我们还将对频率、强度和近端沉淀物进行采样 STB/NSSI 使用每周小型评估 (WMA)。根据初步调查结果，我们将使用 ERP 进行测试关于 RDoC 构造的假设映射到可能导致 STB 和 NSSI 的风险因素，包括对奖励、错误和同伴拒绝的消极和积极反馈的反应。我们将具体测试关于 NSSI 和 STB 的共同危险因素（严重抑郁、同伴排斥、不良生活）的假设事件、严厉的养育，以及 ERP 对损失和同伴拒绝的更强反应，以及 ERP 的迟钝对胜利和社会接受度的反应）以及 NSSI 可能更具选择性的风险因素（更大羞耻、易怒、自我批评和更高的疼痛耐受性）与 STB（归属感降低、更强的绝望和自杀家族史）。鉴于基线时确定的样本年龄较小，我们也有机会调查不同发育阶段的风险差异。拟议的研究提供了前所未有的机会来追踪有史以来最大的 STB 幼儿样本 NSSI 将调查学龄期和青春期早期的发育轨迹，可能确定早期干预的早期发展目标。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neural signatures of data-driven psychopathology dimensions at the transition to adolescence.

向青春期过渡时数据驱动的精神病理学维度的神经特征。

DOI：
发表时间：
2022-01-24
期刊：
影响因子：
0
作者：
Modabbernia, Amirhossein;Michelini, Giorgia;Reichenberg, Abraham;Kotov, Roman;Barch, Deanna;Frangou, Sophia
通讯作者：
Frangou, Sophia

Preschool-Onset Major Depressive Disorder as a Strong Predictor of Suicidal Ideation and Behaviors Into Preadolescence.

学龄前发病的重度抑郁症是青春期前自杀意念和行为的有力预测因素。

DOI：
发表时间：
2023-12-07
期刊：
影响因子：
13.3
作者：
Hennefield, Laura;Whalen, Diana J;Tillman, Rebecca;Barch, Deanna M;Luby, Joan L
通讯作者：
Luby, Joan L

Preschool Depression: a Diagnostic Reality.

学前抑郁症：诊断现实。

DOI：
发表时间：
2019-11-20
期刊：
影响因子：
6.7
作者：
Donohue, Meghan Rose;Whalen, Diana J;Gilbert, Kirsten E;Hennefield, Laura;Barch, Deanna M;Luby, Joan
通讯作者：
Luby, Joan