Intervention and Implementation Science Core

干预和实施科学核心

• 批准号: 9343106
• 负责人: Susan M. KEGELES
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9343106
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adherence; Adoption; Area; Awareness; Basic Science; Behavior Therapy; Behavioral; Caring; Clinical; Clinical Trials Data Monitoring Committees; Collaborations; Complement; Consultations; Development; Discipline; Ensure; Epidemic; Ethics; Evolution; Fostering; Goals; HIV; Health Technology; Individual; International; Intervention; Intervention Studies; Investigation; Knowledge; Life; Literature; Mental Health; Mission; Modality; Policies; Policy Research; Prevention; Prevention approach; Prevention program; Preventive Intervention; Public Health; Research; Research Project Grants; Resources; Science; Scientist; Social Change; Structure; Technology; Testing; Translating; Translations; Treatment outcome; Work; World Health Organization; base; behavioral/social science; effective intervention; efficacy trial; health disparity; human subject; implementation research; implementation science; innovation; meetings; multidisciplinary; next generation; scale up; skills; social; social disparities; therapy design; therapy development; tool

PROJECT SUMMARY HIV prevention science is in a period of marked evolution, prompted by the introduction of biomedical prevention modalities to complement traditional behavioral strategies. The new strategies have created synergies between HIV prevention and treatment outcomes, based on the recognition that there now exists a set of tools that, if utilized in the right combination, could stop the spread of the epidemic and effectively treat the vast majority of individuals living with HIV. Recent policy initiatives place a critical focus on closing the gaps in prevention and care, and on translating interventions into effective practice. We are proposing the addition of the new Intervention and Implementation Science (I&I) Core, to drive the scientific evolution in HIV prevention by integrating research across the spectrum of HIV intervention science, including basic research, efficacy trials, and implementation research. The I&I Core will be guided by the following aims: (1) To galvanize interdisciplinary advances across the spectrum of HIV intervention science, achieved by leveraging the latest findings in basic and HIV-related biomedical, social/behavioral, mental health, public health, and technology- related academic disciplines to inform innovations in HIV intervention design, testing, and scale-up; by identifying areas of complementariness and synergy among clinical, social, and behavioral intervention strategies to support enhanced combination and bio-behavioral HIV prevention approaches; and by fostering collaboration among multidisciplinary scientists to conduct innovative intervention research and guide the translation of effective interventions into practice. (2) To hone the skills among CAPS and its affiliated scientists for working along the spectrum of HIV intervention and implementation science, achieved by increasing knowledge about conventional and cutting-edge intervention development and implementation approaches that are culturally competent, and can be used to address myriad prevention targets, from behavioral, structural, and social change to adoption of and adherence to biomedical advances; and by developing fluency to study and work within diverse organizational, political, and social structures to foster the translation of effective interventions into practice. (3) To assure that CAPS research, including intervention and implementation research, meets the highest ethical standards, achieved by providing consultations on ethical and human subjects issues arising in research projects; increasing awareness about ethical and human subjects issues in this era of greater use of technology; and providing assistance in the formation of Data and Safety Monitoring Boards.

项目摘要 艾滋病毒预防科学在一个明显的进化时期，是由生物医学引入的 预防方式补充传统行为策略。新策略已经创建了 基于认识到现在存在的，预防艾滋病毒和治疗结果之间的协同作用 一组工具，如果在正确的组合中使用，可以停止流行病的传播并有效治疗 绝大多数患有艾滋病毒的人。最近的政策举措将关键的重点放在缩小差距上 在预防和护理中，并将干预措施转化为有效的实践。我们正在提议添加 新的干预和实施科学（I＆I）核心，以推动预防艾滋病毒的科学进化 通过整合跨HIV干预科学范围的研究，包括基础研究，功效 试验和实施研究。 I＆I核心将受到以下目的的指导：（1）镀锌 通过利用最新的艾滋病毒干预科学领域的跨学科进步 基础和HIV相关的生物医学，社会/行为，心理健康，公共卫生和技术的发现 - 相关学科，以告知HIV干预设计，测试和扩大规模的创新；经过 识别临床，社会和行为干预之间的互补性和协同作用领域 支持增强组合和生物行为预防艾滋病毒的方法的策略；并通过寄养 多学科科学家之间的合作，以进行创新的干预研究并指导 将有效的干预措施翻译成实践。 （2）磨练帽子之间的技能及其附属机构 科学家沿着艾滋病毒干预和实施科学的范围工作，由 增加有关常规和尖端干预开发和实施的知识 具有文化胜任的方法，可用于解决众多预防目标 行为，结构和社会变革，对生物医学进步的采用和遵守；和 开发流利的组织，在各种组织，政治和社会结构中进行研究，以促进 将有效的干预措施翻译成实践。 （3）确保限制研究，包​​括干预和 实施研究符合最高的道德标准，通过提供有关道德的咨询而实现的 和人类受试者在研究项目中产生的问题；提高对道德和人类的认识 在这个时代，受试者的技术更多地使用技术；并在形成数据和 安全监控板。