Training Program at the Chemistry Biology Interface

化学生物学接口的培训计划

• 批准号: 10623229
• 负责人: Paul Hergenrother
• 金额: $ 63.66万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623229
• 关键词: Biology; Chemistry; Training Programs

PROJECT SUMMARY A fuller understanding of living systems at the molecular level has led to revolutionary changes in the fields of chemistry and biology and has made the boundary between these traditional disciplines less defined. To leverage the exciting scientific advances at the chemistry-biology interface and to be poised to make major contributions to biology and medicine, chemists and biologists must speak a common scientific language. The Chemistry-Biology Interface Training Program (CBI-TP) at the University of Illinois, Urbana-Champaign (UIUC) will offer an environment in which chemists and biologists can acquire interdisciplinary training that enables them to learn a common language and to acquire a shared set of research skills without compromising their ability to acquire deep discipline-specific knowledge in specialized areas of chemistry or biology. Through shared experiences in the classroom and in the laboratory, the CBI-TP is intended to enhance the studies of graduate students enrolled in six departments at UIUC: Chemistry, Chemical and Biomolecular Engineering, Biochemistry, Microbiology, Cell and Developmental Biology, and Molecular and Integrative Physiology. Each year, 12 trainees will be supported by the NIH, in addition to 5 matching positions supported by UIUC. Highlights of the program include courses specifically developed for the CBI-TP (including a hands-on laboratory course), first year laboratory rotations, strong training in rigor and reproducibility, an opportunity for internships, a highly diverse student body, and extremely strong institutional support. The program also offers unique opportunities for professional and career development including (i) a student-run seminar program during which trainees invite, host, and discuss their research with outside seminar speakers, (ii) creation of Individual Development Plans (IDPs) for which trainees are required to research at least three career options, join a professional organization, and attend at least one career-related workshop, (iii) options to earn relevant certifications such as the Certificate in Entrepreneurship and Management, and/or take part in internships, and (iv) participation in multiple career development activities, intended to better prepare graduate students at the chemistry-biology interface for interesting and challenging career paths and opportunities. No matter their ultimate career goals, the CBI-TP platform at UIUC, running for 14 years now, has no equivalent elsewhere on our campus. The goal of the CBI-TP is to arm trainees with the breadth of education necessary to bridge the gap between the chemical and biological sciences. The trainees have been, and will continue to be, among those scientists making significant contributions to biomedicine as participants in and leaders of multidisciplinary teams in industry, government, or academia.

项目概要 在分子水平上对生命系统的更全面的理解导致了以下领域的革命性变化 化学和生物学，使这些传统学科之间的界限变得不那么明确。到 利用化学-生物学界面令人兴奋的科学进步，并准备做出重大贡献 为了对生物学和医学做出贡献，化学家和生物学家必须使用共同的科学语言。这 伊利诺伊大学厄巴纳-香槟分校 (UIUC) 化学-生物界面培训计划 (CBI-TP) 将提供一个环境，让化学家和生物学家能够接受跨学科培训，使 他们学习共同语言并获得一套共享的研究技能，而不影响他们的能力 获得化学或生物学专业领域的深入学科特定知识的能力。通过 在课堂和实验室分享经验，CBI-TP 旨在加强以下方面的研究： UIUC 六个系的研究生：化学、化学和生物分子工程、 生物化学、微生物学、细胞和发育生物学以及分子和综合生理学。每个 今年，除了 UIUC 支持的 5 个匹配职位外，NIH 将支持 12 名实习生。 该计划的亮点包括专门为 CBI-TP 开发的课程（包括实践课程） 实验室课程）、第一年实验室轮换、严格性和可重复性方面的严格培训、 实习、高度多样化的学生群体以及极其强大的机构支持。该计划还提供 独特的专业和职业发展机会，包括（i）学生举办的研讨会计划 在此期间，学员邀请、主持并与外部研讨会发言人讨论他们的研究，(ii) 创建 个人发展计划（IDP），要求学员研究至少三种职业选择， 加入专业组织，并参加至少一次与职业相关的研讨会，(iii) 获得相关职位的选择 诸如创业和管理证书之类的认证，和/或参加实习，以及 (iv) 参与多项职业发展活动，旨在为研究生更好地做好准备 化学-生物学界面，提供有趣且具有挑战性的职业道路和机会。无论他们的 UIUC 的 CBI-TP 平台已经运行了 14 年，在其他地方没有类似的平台 我们的校园。 CBI-TP 的目标是为学员提供必要的广泛教育，以弥合 化学和生物科学之间的差距。学员已经并将继续是 这些科学家作为生物医学的参与者和领导者做出了重大贡献 工业界、政府或学术界的多学科团队。

项目成果

Toward Understanding the Subcellular Distributions of Cholesterol and Sphingolipids Using High-Resolution NanoSIMS Imaging.

使用高分辨率 NanoSIMS 成像了解胆固醇和鞘脂的亚细胞分布。

• 发表时间: 2023-04-04
• 影响因子: 18.3
• 作者: Brunet, Melanie A;Kraft, Mary L
• 通讯作者: Kraft, Mary L

Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation.

通过小分子介导的 MEK 降解克服靶向抗癌治疗的耐药性。

• DOI: 10.1016/j.chembiol.2018.05.008
• 发表时间: 2018-08-16
• 期刊: Cell chemical biology
• 影响因子: 8.6
• 作者: Peh J;Boudreau MW;Smith HM;Hergenrother PJ
• 通讯作者: Hergenrother PJ

The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics.

将仅限革兰氏阳性的化合物转化为广谱抗生素的挑战。

• 发表时间: 2019
• 影响因子: 5.2
• 作者: Richter, Michelle F;Hergenrother, Paul J
• 通讯作者: Hergenrother, Paul J

Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers.

在犬和人脑癌中使用 PAC-1（一种 Procaspase-3 激活剂）作为药物靶标，对 Procaspase-3 过表达进行免疫组织化学表征。

• 发表时间: 2019
• 作者: Schlein, Lisa J;Fadl;Pondenis, Holly C;Lezmi, Stéphane;Eberhart, Charles G;LeBlanc, Amy K;Dickinson, Peter J;Hergenrother, Paul J;Fan, Timothy M
• 通讯作者: Fan, Timothy M

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis.

截短侧耳素的多种化合物可产生硫氧还蛋白抑制剂和铁死亡诱导剂。

• 发表时间: 2019
• 影响因子: 21.8
• 作者: Llabani, Evijola;Hicklin, Robert W;Lee, Hyang Yeon;Motika, Stephen E;Crawford, Lisa A;Weerapana, Eranthie;Hergenrother, Paul J
• 通讯作者: Hergenrother, Paul J