Enhancing Vivarium Efficiency and Safety at South Dakota State University with a Modernized Pass-Through Autoclave

使用现代化的直通式高压灭菌器提高南达科他州立大学动物饲养场的效率和安全性

• 批准号: 10737439
• 负责人: Michele Rene Mucciante
• 金额: $ 25.81万
• 依托单位: SOUTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10737439
• 关键词: 20 year old; Affect; Animal Experimentation; Animal Welfare; Animals; Award; Biological; Biology; Biomedical Research; Centers of Research Excellence; Charge; Chemistry; Communities; Contracts; Dedications; Discipline; Equipment; Failure; Funding; Gnotobiotic; Industry Standard; Infectious Diseases Research; Infrastructure; Investments; Laboratory Animal Production and Facilities; Lead; Maintenance; Modeling; Modernization; Personal Satisfaction; Pharmacy facility; Phase; Positioning Attribute; Procedures; Process; Reporter; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Risk; Safety; Savings; Scheme; Science; Services; South Dakota; Sterilization; Training; United States National Institutes of Health; Universities; Vendor; Veterinarians; Veterinary Medicine; Work; animal breeding; animal care; biosecurity; cost; end of life; energy efficiency; improved; occupational health/safety; operation; programs; service providers; square foot; surgical service

Project Summary/Abstract The shared-use animal research facility (vivarium) at South Dakota State University (SDSU) aims to improve occupational health and safety of staff and support growing the capacity and variety of biomedical research with the installation of a modern, large capacity pass-through autoclave. The current small, single-door model autoclave is near end-of-life with 20+ years of service and increased maintenance costs. This increased risk of failure or extended downtime due to maintenance could jeopardize research projects, including those supported by a $10.8 million NIH COBRE Phase 1 award. The SDSU vivarium supports research across multiple disciplines from biology, chemistry, and pharmacy to veterinary medicine and animal science. Among those supported by NIH, SDSU investigators currently lead 10 projects with $5.3+ million in active awards (NIH RePORTER, accessed Nov. 4, 2022). More than half of this funding supports investigators who currently use the vivarium for their research. The vivarium’s modernization effort is driven by not only the needs of NIH-funded investigators’ but of the overall needs of investigators using the shared-use facility. The university has responded with investing in and prioritizing infrastructure for biomedical research needs. Specifically, the 33,495-square foot facility supports BSL1, BSL2, BSL 2+ (BSL = Biological Safety Levels) and gnotobiotic animal research programs for the university and surrounding research community. The university veterinarian, the vivarium manager, and technicians work directly with researchers in daily and on-going research support needs. Services include a range of options from basic animal care and breeding colony management to complete gnotobiotic and surgical services. The university’s strategic priority of improving research infrastructure guides the modernization of the facility in recent years and has required a high level of oversight and management by the university veterinarian and vivarium staff. In modernizing the autoclave, a core piece of equipment, the vivarium will increase efficiencies in biosecurity, animal welfare and compliance, staff labor and support services, equipment operations and maintenance. This will provide researchers more comprehensive use of the vivarium, opportunity for expanding their projects, and increased capacity to support the university’s growing biomedical research.

项目概要/摘要 南达科他州立大学的共享动物研究设施（动物园） (SDSU) 旨在改善员工的职业健康和安全，并支持发展 通过安装现代化的大型生物医学研究能力和多样性 目前的小型单门型高压灭菌器即将问世。 使用寿命已超过 20 年，且维护成本增加。 由于维护而出现故障或延长停机时间的风险可能会危及研究 项目，包括由 NIH COBRE 第一阶段奖金 1080 万美元支持的项目。 SDSU 动物园支持生物学、 其中包括化学、药学、兽医学和动物科学。 在 NIH 的支持下，SDSU 的研究人员目前领导着 10 个项目，总投资超过 530 万美元。 积极奖励（NIH Reporter，2022 年 11 月 4 日访问）超过一半的资金。 支持目前使用动物园进行研究的研究人员。 现代化的努力不仅是由 NIH 资助的研究人员的需求驱动的，而且是由 大学研究人员使用共享设施的总体需求。 对此，我们投资并优先考虑了满足生物医学研究需求的基础设施。 具体来说，这个占地 33,495 平方英尺的设施支持 BSL1、BSL2、BSL 2+（BSL = 生物安全水平）和大学的限生动物研究项目 和周围的研究社区大学兽医、动物园。 管理人员和技术人员直接与研究人员一起进行日常和正在进行的研究 支持需求。服务包括基本动物护理和育种等一系列选择。 群体管理以完成大学的生殖和外科服务。 完善科研基础设施是引领科研现代化的战略重点 近年来，该设施需要高水平的监督和管理 大学兽医和动物园工作人员。 在对核心设备高压灭菌器进行现代化改造时，动物园将增加 生物安全、动物福利和合规性、员工劳动力和支持方面的效率 这将为研究人员提供更多服务、设备操作和维护。 综合利用动物园、扩大项目的机会，以及 提高支持大学不断发展的生物医学研究的能力。