Comprehensive Translational Science Analytics Tools for the Global Health Agenda

全球健康议程的综合转化科学分析工具

• 批准号: 8928183
• 负责人: DONNA L SPIEGELMAN
• 金额: $ 80.75万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-16 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8928183
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adoption; Biomedical Research; Books; Child Mortality; Computer software; Decision Making; Development; Educational Curriculum; Educational process of instructing; Effectiveness; Epidemic; Evaluation; Evidence based practice; Federal Government; Goals; HIV; Health; Health Policy; Health Professional; Hospitals; Human; Intention; Intervention; Investments; Local Government; Medicare; Methodology; Methods; Monograph; Outcome; Peer Review; Principal Investigator; Public Health; Publications; Relative (related person); Research; Research Personnel; Resources; Science; State Government; Translational Research; Translations; United States; United States National Institutes of Health; career; clinical practice; cost effectiveness; evidence base; global health; implementation science; improved; innovation; intervention program; meetings; novel; programs; sound; tool

DESCRIPTION (provided by applicant): The NIH has declared its intention to leverage the power of science to identify health interventions that yield the greatest benefits by assessing their relative effectiveness and cost-effectiveness in real- world settings. Thus, evidence-based approaches will guide the translation of basic biomedical research into routine clinical practice and public health policy. The NIH's commitment aligns with the Sydney Declaration, signed by more than 2,000 public health professionals worldwide. This Declaration recommends that 10% of all resources dedicated to HIV programming be used for research towards optimizing interventions utilized and health outcomes achieved, and asserts that without such a sustained effort, ending the HIV/AIDS epidemic will not be possible. Despite calls for greater investment, substantive innovation in implementation science methodology has not yet materialized. Development of relevant and accessible methodology and software to enable sound evidence-based practice stands to contribute importantly to meeting the Millennium Development Goals; specifically, ending the HIV/AIDS epidemic, providing universal access to AIDS treatment, and reducing maternal and under-5 child mortality. The United States, as the world's leading funder of HIV/AIDS relief and other global health initiatives, has a vital stake in an evidence-based deployment of this massive investment in improving health and alleviating human suffering worldwide. The purpose of this proposal is to advance the emerging field of implementation science by developing a comprehensive translational science analytics toolkit-a much needed resource for investigators, practitioners, and policymakers who seek to drive today's global and domestic health agenda through the integration of research findings and evidence into healthcare policy and practice. The principal investigator will undertake a fundamental shift in her career trajectory, to develop new methods and adapt existin

描述（由申请人提供）：NIH宣布打算利用科学的力量来确定健康干预措施，从而通过评估其相对效率和成本效益在现实世界环境中获得最大的收益。因此，基于证据的方法将指导将基本生物医学研究转化为常规临床实践和公共卫生政策。 NIH的承诺与悉尼宣言相吻合，该声明由全球2,000多名公共卫生专业人员签署。该声明建议将专门用于HIV计划的所有资源的10％用于研究，用于优化所利用的干预措施和实现的健康成果，并断言，如果不持续的努力，就无法结束HIV/AIDS流行病。尽管呼吁进行更大的投资，但实施科学方法论的实质创新尚未实现。开发相关且可访问的方法和软件，以使循证实践能够为实现千年发展目标做出重要贡献；具体而言，结束艾滋病毒/艾滋病流行，提供了普遍获得艾滋病治疗的机会，并降低了孕产妇和5岁以下儿童死亡率。作为全球艾滋病毒/艾滋病救济和其他全球健康计划的全球领先资助者，美国在基于证据的部署这一大规模投资方面具有至关重要的股份，以改善健康和减轻全球人类苦难。 该提案的目的是通过开发全面的转化科学分析工具包来推进新兴的实施科学领域 - 为研究人员，从业人员和政策制定者提供了急需的资源，这些资源通过将研究发现和证据整合到医疗保健政策和实践中，试图推动当今的全球和家庭医疗议程。首席调查员将在她的职业轨迹上进行基本转变，以开发新方法和适应