New methods for the design and evaluation of large HIV prevention interventions

设计和评估大型艾滋病毒预防干预措施的新方法

基本信息

批准号：
8729765
负责人：
DONNA L SPIEGELMAN
金额：
$ 67.18万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8729765
关键词：
AIDS prevention Address Africa Africa South of the Sahara Area Attenuated Botswana Cellular Phone Clinical Trials Design Collaborations Communities Computer software Data Data Analyses Development Discipline Disease Effectiveness Ethics Evaluation HIV HIV Infections HIV prevention trial HIV prevention trials network Health Human Resources Impact evaluation Incidence Intervention Interviewer Investigation Libraries Measurement Methodology Methods Modeling Observational Study Outcome Performance Population Prevention Prevention Research Preventive Intervention Principal Investigator Proxy Randomized Randomized Clinical Trials Recommendation Research Research Design Research Personnel Robin bird Science South Africa Statistical Methods Stratification Structural Models Tanzania Testing Time Uncertainty Vertical Disease Transmission Work Zambia antiretroviral therapy base comparative effectiveness cost cost effectiveness design experience follow-up improved models and simulation novel novel strategies prevent prevention clinical trial prevention evaluation programs randomized trial scale up social tool transmission process treatment center user-friendly validation studies web site

AIDS prevention Address Africa Africa South of the Sahara Area Attenuated Botswana Cellular Phone Clinical Trials Design Collaborations Communities Computer software Data Data Analyses Development Discipline Disease Effectiveness Ethics Evaluation HIV HIV Infections HIV prevention trial HIV prevention trials network Health Human Resources Impact evaluation Incidence Intervention Interviewer Investigation Libraries Measurement Methodology Methods Modeling Observational Study Outcome Performance Population Prevention Prevention Research Preventive Intervention Principal Investigator Proxy Randomized Randomized Clinical Trials Recommendation Research Research Design Research Personnel Robin bird Science South Africa Statistical Methods Stratification Structural Models Tanzania Testing Time Uncertainty Vertical Disease Transmission Work Zambia antiretroviral therapy base comparative effectiveness cost cost effectiveness design experience follow-up improved models and simulation novel novel strategies prevent prevention clinical trial prevention evaluation programs randomized trial scale up social tool transmission process treatment center user-friendly validation studies web site

展开

项目摘要

DESCRIPTION (provided by applicant): The advent of newly discovered efficacious tools for the prevention of HIV creates a new challenge and the need for new paradigms: How do we assess the impact of combinations of HIV prevention tools in ethical ways, when we have evidence that individually they work to reduce HIV transmission? How do we roll out efficacious strategies, but assess their effectiveness and cost-effectiveness in real-world settings at scale? In a powerful collaboration between four of the major HIV preventive interventions currently underway - including Harvard's Botswana Community Prevention Project and Familia Salama study of PMTCT, Vanderbilt and Imperial's PopART project, and the Africa Centre's Treatment as Prevention trial, our proposal, entitled "New methods for the design and evaluation of large HIV prevention interventions" will address key gaps in the available methodologies for the design and analysis of these large- scale HIV preventive intervention projects. After extensive dialogue with the Principal Investigators and other key personnel on these projects (three of whom are Co-investigators of this proposal), we have identified our specific aims as: 1) To develop and validate novel network methods to improve the evaluation of large combination prevention clinical trials 2) To develop advanced statistical methods to improve the design and evaluation of large- scale HIV prevention studies. 3) To augment prevention trial designs to adjust for bias due to loss to follow-up and to assess infectiousness and indirect effects. 4) To disentangle and evaluate the effects of specific interventions that comprise a 'package' as in the Harvard-Botswana and HPTN 061/PopART trials

描述（由申请人提供）：新发现的有效工具的出现来预防艾滋病毒会带来新的挑战和对新范式的需求：我们如何评估以道德方式以道德方式评估预防艾滋病毒预防工具的影响，而当我们有证据表明它们单独工作以减少艾滋病毒的传播？我们如何制定有效的策略，但要评估其在现实世界中的有效性和成本效益？在目前正在进行的四项主要艾滋病毒预防干预措施之间进行了强有力的合作 - 包括哈佛大学的博茨瓦纳社区预防项目和对PMTCT，范德比尔特和帝国的Popart项目的Familia Salama研究，以及非洲中心作为预防试验的待遇，我们的建议，我们的建议，我们有权“用于大型HIV预测干预措施的新方法”，这些方法是针对大型HIV预测式赫斯特的研究。预防干预项目。 After extensive dialogue with the Principal Investigators and other key personnel on these projects (three of whom are Co-investigators of this proposal), we have identified our specific aims as: 1) To develop and validate novel network methods to improve the evaluation of large combination prevention clinical trials 2) To develop advanced statistical methods to improve the design and evaluation of large- scale HIV prevention studies. 3）增加预防试验设计，以调整由于失去随访并评估传染性和间接影响而导致的偏见。 4）除了哈佛 - 博茨瓦纳和HPTN 061/popart试验中，构成“包装”的特定干预措施的效果