ShEEP Request for Vevo 3100 Imaging System

ShEEP 请求 Vevo 3100 成像系统

• 批准号: 9213727
• 负责人: DAVID M ROTH
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9213727
• 关键词: Address; Age-Years; Animals; Blood flow; Cardiovascular system; Data Quality; Disease; Equipment; Female; Frequencies; Gene Delivery; Goals; Health; Heart Diseases; Image; Injection of therapeutic agent; Intervention; Investigation; Kidney; Left; Link; Measures; Morphologic artifacts; Mus; Myocardial; Myocardial Ischemia; Nephrology; Organ; Oryctolagus cuniculus; Pelvis; Phase; Population; Post-Traumatic Stress Disorders; Rattus; Renal Tissue; Reporting; Research; Research Personnel; Resolution; Services; Staging; Structure; System; Techniques; Technology; Time; Tissues; Ultrasonography; Ventricular; Veterans; Virus; Visual; agent orange; burden of illness; clinical investigation; cost efficient; data acquisition; high throughput analysis; image processing; imaging modality; imaging system; improved; male; non-invasive imaging; novel; pre-clinical; response; statistics; vector

Medical ultrasound techniques are widely used for pre-clinical investigations. These non-invasive imaging modalities are crucial for researchers to observe changes in organ/tissue structure, size, and blood flow during disease stages as well as in response to pharmacological interventions. The requested equipment is an ultra high-frequency ultrasound machine (Vevo3100, FUJIFILM, VisualSonics) specifically manufactured to image mice, rats, and rabbits. The Vevo 3100 system will be equipped with a linear phased array ultrasound probe specific for animals in the size range of rabbits that is not currently available on our existing equipment. The Vevo 3100 system also has several upgrades in the ultrasound technology including; 1) improved resolution, 2) reduced artifact, 3) real time image processing, 4) left ventricular tracing, 5) improved workflow for rapid data acquisition, 6) speckle tracking analysis (for strain analysis), 7) an imaging station equipped with injection mount (for echo guided tissue injections), and 8) a high throughput analysis. All these functionalities would make this system a necessary part of our goal to produce high quality data in a time and cost efficient manner. Additionally, the Vevo 3100 system with high- resolution ultrasound has applications in nephrology by providing excellent delineation of renal tissues, the technology to quantify and analyze kidney size, and the ability to measure blood flow throughout the pelvic region. The functionality of this novel Vevo 3100 will allow our cardiovascular research groups (Drs. Roth, Patel, Dillmann, Hammond, Ross, and Mahata) as well as our colleagues in the nephrology department (Drs. Sharma, Singh, and Rajasekaran) the opportunities to expand their experimental capabilities.

医学超声技术被广泛用于临床前研究。这些无创 成像方式对于研究人员观察器官/组织结构，大小和 疾病阶段的血流以及对药理干预措施的响应。 请求的设备是一台超高频超声机器（VEVO3100，富士， 专门为小鼠，大鼠和兔子制造而制造的Visualsonics）。 VEVO 3100系统将配备一个线性相分析阵列超声探针特定于 当前我们现有设备上目前尚不可用的兔子大小范围的动物。这 VEVO 3100系统在超声技术中还具有多次升级，包括： 1）改进 分辨率，2）减少伪像，3）实时图像处理，4）左心室示踪，5）改进 快速数据获取的工作流程，6）斑点跟踪分析（用于应变分析），7）成像 装有注入安装的站（用于回声引导的组织注射）和8）高吞吐量 分析。所有这些功能将使该系统成为我们生产的必要部分 高质量的数据和成本效益的方式。此外，具有高的VEVO 3100系统 分辨率超声通过提供肾脏的出色描述在肾脏科中应用 组织，量化和分析肾脏大小的技术以及测量血流的能力 整个骨盆区域。 这个新颖的VEVO 3100的功能将允许我们的心血管研究小组（Roth Dr. Roth， Patel，Dillmann，Hammond，Ross和Mahata）以及我们的同事 部门（Sharma Dr. Sharma，Singh和Rajasekaran）有机会扩大实验性 功能。