Ultrahigh-Field MRI of Hip Joint Diseases Leading to Early Osteoarthritis

导致早期骨关节炎的髋关节疾病的超高场 MRI

基本信息

批准号：
10242741
负责人：
Casey Peter Johnson
金额：
$ 12.99万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10242741
关键词：
3-Dimensional Acute Address Arthroscopic Surgical Procedures Basic Science Bone necrosis Brain Diseases Capital Cartilage Child Clinical Clinical Management Clinical Research Clinical Treatment Contralateral Degenerative polyarthritis Development Diagnosis Diagnostic Disease Disease Management Disease Progression Disease model Doctor of Philosophy Dysplasia Early Diagnosis Educational workshop Environment Fibrocartilages Foundations Future Goals Head Hip Joint Hip Osteoarthritis Hip region structure Histologic Histology Hour Image Imaging Device Imaging Techniques Imaging technology Ischemia Joints Legg-Perthes Disease Location Magnetic Resonance Magnetic Resonance Imaging Maps Marrow Measures Mentored Research Scientist Development Award Mentors Minnesota Monitor Morphology Musculoskeletal Musculoskeletal Diseases Musculoskeletal System Noise Operative Surgical Procedures Orthopedic Surgery Outcome Pathologic Pathology Patient Care Patient imaging Patients Phase RF coil Radiology Specialty Relaxation Research Resolution Resources Schedule Sensitivity and Specificity Signal Transduction Site Specimen Structure Techniques Technology Therapeutic Thinness Time Tissues Total Hip Replacement Training Translational Research Treatment Efficacy Universities Validation Vascular Diseases Veterinary Medicine arthropathies bone clinical care clinical imaging contrast imaging disability early onset experience healing imaging modality imaging system improved innovation joint injury magnetic field musculoskeletal imaging non-invasive imaging porcine model pre-clinical preclinical imaging premature prevent programs research study skills support network symposium time use tool transmission process

项目摘要

PROJECT SUMMARY: This K01 award will provide training and protected time for Dr. Casey P. Johnson, PhD, to develop an independent research program to address a critical need for new imaging solutions to improve the clinical management of developmental hip joint diseases that are precursors to osteoarthritis (OA). As there is no cure for OA and end treatment is total hip replacement, it is imperative to diagnose and treat early hip pathologies before irreversible damage occurs to prevent long-term disability and progression to OA. However, management of these diseases, which include (among others) Legg-Calve-Perthes disease (LCPD) and femoroacetabular impingement (FAI), is hindered by a lack of sensitive and high-spatial-resolution imaging tools to evaluate early, potentially treatable, bone and cartilage damage. To address this challenge, Dr. Johnson will develop and validate techniques to quantitatively assess hip damage using ultrahigh-field (UHF) (≥7 Tesla) magnetic resonance imaging (MRI), the technological future for high-spatial-resolution imaging of the musculoskeletal (MSK) system. Dr. Johnson has a strong background in the development of efficient, quantitative, and high-resolution MRI methods and their application to vascular and brain diseases, making him uniquely qualified to advance UHF MRI of multifactorial MSK diseases. During the K01 award’s five-year training period, Dr. Johnson will develop his expertise in MSK imaging research, enhance his professional skills, and establish a network of support within the MSK and MRI research fields. He will be mentored by and collaborate with experts in radiology, orthopaedic surgery, pathology, veterinary medicine, and UHF MRI and receive structured training through coursework, seminars, workshops, scientific conferences, and hands-on experiences. Dr. Johnson’s research will be embedded within the University of Minnesota’s Center for Magnetic Resonance Research, a world-renowned research environment for the development and application of UHF MRI technology. Two specific aims will provide training in: (i) preclinical imaging of specimens using a small-bore 9.4T MRI system with histological validation; and (ii) clinical imaging of patients using a whole-body 7T MRI system with surgical validation. Aim 1 will develop and histologically validate, in a piglet model of LCPD, techniques to quantitatively assess early ischemia-induced changes to femoral head marrow, cartilage, and bone. This will address a need to stage LCPD in children prior to femoral head fragmentation. Aim 2 will develop and arthroscopically validate, in patients with FAI, techniques to quantitatively assess cartilage and labral damage. This will address a need to determine the extent of damage to identify candidates for reparative arthroscopic surgery. UHF MRI development will focus on T2, T2*, and T1ρ mapping using both short and ultrashort echo-time sequences to quantify tissues with both slowly- (cartilage and marrow) and rapidly- (bone and labrum) decaying MRI signals. This research will provide Dr. Johnson with a strong foundation to advance imaging to improve long-term clinical outcomes for young patients with hip and other joint diseases.

项目摘要：该 K01 奖项将为 Casey P. Johnson 博士提供培训和受保护的时间，博士，开发一个独立的研究计划，以满足对新成像解决方案的迫切需求改善骨关节炎 (OA) 前兆的发育性髋关节疾病的临床管理。由于骨关节炎无法治愈，最终治疗是全髋关节置换术，因此诊断和治疗势在必行在发生不可逆损伤之前预防早期髋部病变，以防止长期残疾和进展为 OA。然而，这些疾病的管理，其中包括（除其他外）Legg-Calve-Perthes 病 (LCPD) 和股骨髋臼撞击（FAI），由于缺乏敏感和高分辨率的成像而受到阻碍评估早期、可能可治疗的骨和软骨损伤的工具为了应对这一挑战，博士。约翰逊将开发并验证使用超高场 (UHF) 定量评估髋部损伤的技术 (≥7 Tesla) 磁共振成像 (MRI)，高空间分辨率成像的技术未来约翰逊博士在肌肉骨骼 (MSK) 系统的开发方面拥有深厚的背景。定量、高分辨率 MRI 方法及其在血管和脑部疾病中的应用，使他在 K01 奖的五年期间，具有推动多因素 MSK 疾病的 UHF MRI 发展的独特资格。培训期间，Johnson博士将发展他在MSK影像研究方面的专业知识，提升他的专业水平他将接受 MSK 和 MRI 研究领域的指导。与放射学、骨科手术、病理学、兽医学和 UHF MRI 领域的专家合作通过课程、研讨会、讲习班、科学会议和实践接受结构化培训约翰逊博士的研究将纳入明尼苏达大学的研究中心。磁共振研究，世界知名的开发和应用研究环境 UHF MRI 技术的两个具体目标将提供以下方面的培训：(i) 使用经过组织学验证的小口径 9.4T MRI 系统；以及 (ii) 使用全身对患者进行临床成像经过手术验证的 7T MRI 系统将在仔猪模型中进行开发和组织学验证。 LCPD，定量评估早期缺血引起的股骨头骨髓、软骨变化的技术，这将解决在目标 2 之前对儿童进行 LCPD 分期的需要。开发并在 FAI 患者中通过关节镜验证定量评估软骨和这将解决确定损伤程度以确定修复候选者的需要。关节镜手术的 UHF MRI 开发将侧重于使用短和 T2、T2* 和 T1ρ 映射。超短回波时间序列可量化具有慢速（软骨和骨髓）和快速（骨）的组织这项研究将为约翰逊博士的发展奠定坚实的基础。成像技术可改善患有髋关节和其他关节疾病的年轻患者的长期临床结果。