Cardiometabolic Core

心脏代谢核心

• 批准号: 10579230
• 负责人: Sarah H. Lindsey
• 金额: $ 45.03万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10579230
• 关键词: Animal Feed; Animals; Area; Biological Markers; Blood Pressure; Body Composition; Body Weight; Calendar; Cardiac; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cognitive aging; Communities; Data; Data Collection; Dedications; Diet; Disease; Disease model; Engineering; Ensure; Enzyme-Linked Immunosorbent Assay; Equipment; Estrogens; Experimental Designs; Extramural Activities; Female; Glucagon; Glucose tolerance test; Goals; Health; High Fat Diet; Housing; Human Resources; Insulin; Maintenance; Measurement; Metabolic; Metabolic Diseases; Metabolic hormone; Monitor; Mus; Phytoestrogens; Procedures; Protocols documentation; Radioimmunoassay; Rattus; Renin-Angiotensin System; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Reservations; Resources; Sampling; Schedule; Schools; Science; Services; Standardization; System; Tissue Banks; Tissues; cardiometabolism; experience; feeding; forest; improved; in vivo; insulin tolerance; medical schools; meetings; programs; sample collection; standardize measure; synergism; ultrasound; web site

Cardiometabolic Core (Core B) Summary The Cardiometabolic Core (Core B) will allow for the careful planning and coordination of research designs, disease models, and data collection among the four Research Projects. The Core will be utilized for the induction, maintenance, and analysis of cardiometabolic diseases in rats and mice. Core B will be a newly established facility housing the equipment and personnel for standardized measures in the proposed Research Projects. The specific functions of Core B are organized into three Aims. Aim 1 will employ standardized animal diets and specimen collection across all four projects. It will ensure that feeding, monitoring, and tissue collection are consistent across projects and will establish a tissue bank available to Tulane and extramural researchers. Aim 2 will employ standardized metabolic measurements across all four projects to provide the same metabolic conditions and measurements. Aim 3 will employ standardized cardiovascular measurements across all four projects to ensure that cardiovascular disease is implemented equally in rats and mice. This coordination among the projects will improve the scope of the research by allowing inferences between studies that could not be made if each project introduced new variables. In addition, Core B will maintain standardized protocols and procedures to allow comparison of data across studies and thereby will improve rigor and reproducibility.

心脏代谢核心（核心 B）总结 心脏代谢核心（核心 B）将允许仔细规划和协调研究设计， 疾病模型以及四个研究项目之间的数据收集。核心将用于感应， 大鼠和小鼠心脏代谢疾病的维护和分析。核心B将是一个新成立的 容纳拟议研究项目中标准化措施的设备和人员的设施。 核心B的具体功能分为三个目标。目标 1 将采用标准化动物饮食 所有四个项目的样本收集。它将确保喂养、监测和组织采集 各个项目保持一致，并将建立一个可供杜兰大学和校外研究人员使用的组织库。目的 2 将在所有四个项目中采用标准化代谢测量，以提供相同的代谢 条件和测量。目标 3 将在所有四个方面采用标准化心血管测量 确保心血管疾病在大鼠和小鼠中平等实施的项目。这种协调 这些项目将通过允许无法进行的研究之间的推论来扩大研究范围 如果每个项目引入新变量。此外，Core B 将维护标准化协议和 程序允许比较研究之间的数据，从而提高严谨性和可重复性。