Reducing Lung Cancer Risk among Appalachian Women Using Community‐Engaged Intervention Research

利用社区参与干预研究降低阿巴拉契亚女性患肺癌的风险

基本信息

批准号：
10579417
负责人：
Jessica Ruth Thompson
金额：
$ 10.43万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10579417
关键词：
18 year old Active Learning Address Affect Appalachian Region Area Attitude Awareness Behavior Behavior Therapy Behavioral Cancer Center Cancer Etiology Cancer Intervention Cessation of life Chronic Disease Chronic stress Clinical Sciences Collaborations Communities Coping Behavior Country County Development Development Plans Diagnosis Economically Deprived Population Effectiveness of Interventions Enrollment Environment Environmental Exposure Environmental Risk Factor Equity Evidence based intervention Farm Funding Future Gender Goals Health Health Technology High Risk Woman Incidence Individual Insurance Intervention Intervention Studies Intervention Trial Kentucky Knowledge Literature Malignant Neoplasms Malignant neoplasm of lung Mentors Mentorship Methods Mining Modeling NCI-Designated Cancer Center Needs Assessment Participant Passive Smoking Perception Persons Phase Population Postdoctoral Fellow Poverty Preventive Preventive screening Preventive service Process Protocols documentation Psychosocial Factor Quality of life Radon Randomized, Controlled Trials Research Research Methodology Research Personnel Risk Risk Factors Risk Reduction Rural Rural Appalachia Sample Size Science Scientist Self Efficacy Series Smoking Source Specificity Surveys System Targeted Research Training Translational Research Trust United States National Institutes of Health Universities Water Woman cancer health disparity cancer risk care giving burden career development clinical center community center community-level factor disorder prevention experience falls geographic disparity health care availability health disparity health disparity populations health economics health equity human centered design implementation cost implementation science improved intervention mapping intervention refinement lung cancer prevention men model building mortality non-smoker pilot test primary care provider public policy on tobacco satisfaction service providers sex skills social socioeconomic disadvantage socioeconomic disparity therapy development training opportunity

项目摘要

PROJECT SUMMARY Appalachian women are at high risk for lung cancer. Lung cancer is the leading cause of cancer-related death for women in the US, including the Appalachian region. Although lung cancer rates have declined steadily among men since the 1990s, such decreases have not been seen among women, including alarming mortality rates in Central Appalachia. Interventions to reduce lung cancer risk among Appalachian women need to consider social and environmental contexts. Research: This project, titled Reducing Lung Cancer Risk among Appalachian Women Using Community-Engaged Intervention Research, relies on community perspectives to guide the selection, adaptation, and pilot testing of a culturally-targeted intervention to reduce lung cancer risk among Appalachian women. We will employ the NIH model for creating behavioral intervention trials to inform the refinement of an intervention through direct community input (Phase 1a; Aim 1; K99) and to pilot test the selected and adapted intervention protocol using a 2-armed randomized controlled trial (Phase 1b; Aim 2; R00). In the pilot with Central Appalachian KY women, we will demonstrate the feasibility of the adapted intervention protocol, including demand, acceptability, and implementation. The selected intervention will seek to increase knowledge, self-efficacy, and targeted behaviors among Appalachian women thereby reducing their future lung cancer risk and, ultimately, lung cancer disparities among women in the Appalachian region. Candidate: Dr. Jessica Thompson is a postdoctoral scholar in an NCI-designated cancer center at the University of Kentucky (UK) with extensive previous training in community-engaged mixed methods research and chronic disease prevention among Appalachian women. Three training goals will enhance her trajectory toward becoming an independent investigator, including developing expertise in: 1) the use of participatory systems science and community- engaged approaches to select and adapt an intervention; 2) lung cancer prevention and risk reduction interventions; and 3) intervention development and implementation science. Mentors/Environment: Dr. Thompson’s career development plan includes substantial mentorship, didactic training, and experiential learning at the UK Markey Cancer Center (MCC) with additional support from the UK Center for Health Equity Transformation (CHET) and the UK Center for Clinical and Translational Science (CCTS). She will receive direct mentorship from MCC Community Impact Office director Dr. Pamela Hull (Primary Mentor) and CHET director Dr. Nancy Schoenberg (Co-Primary Mentor) with additional mentorship from Dr. Ellen Hahn (Mentor) in lung cancer prevention and risk reduction, Dr. Teresa Waters (Mentor) in assessments of intervention effectiveness and health economics, and Dr. Jessica Burke (Mentor; University of Pittsburgh) in systems science and participatory methods. Overall, the objectives of this K99/R00 application will advance lung cancer intervention research for Appalachian women by providing evidence for a future R01 submission and support Dr. Thompson’s training as an independent scientist in implementing interventions to improve the health of Appalachian women.

项目概要阿巴拉契亚女性患肺癌的风险很高，肺癌是癌症相关死亡的主要原因。尽管美国（包括阿巴拉契亚地区）女性的肺癌发病率稳步下降。自 20 世纪 90 年代以来，男性死亡率下降，但女性死亡率却未见下降，包括令人震惊的死亡率中部阿巴拉契亚地区降低阿巴拉契亚地区女性肺癌风险的干预措施需要考虑社会因素研究：该项目名为“降低阿巴拉契亚地区的肺癌风险”。妇女利用社区参与干预研究，依靠社区观点来指导选择、适应和试点测试针对文化的干预措施，以降低肺癌风险我们将采用 NIH 模型来创建行为干预试验，以告知妇女。通过直接社区投入完善干预措施（阶段 1a；目标 1；K99）并试点测试所选方案并使用 2 组随机对照试验调整干预方案（第 1b 期；目标 2；R00）。与肯塔基州中部阿巴拉契亚地区的女性进行试点，我们将展示改编后的干预方案的可行性，包括需求、可接受性和实施。选定的干预措施将寻求增加知识，阿巴拉契亚女性的自我效能和有针对性的行为可降低她们未来患肺癌的风险最终，阿巴拉契亚地区女性的肺癌差异。候选人：杰西卡博士。 Thompson 是英国肯塔基大学 NCI 指定癌症中心的博士后学者先前在社区参与的混合方法研究和慢性病预防方面接受过广泛的培训阿巴拉契亚女性中的三个培训目标将增强她成为独立人士的轨迹。研究者，包括发展以下方面的专业知识：1）使用参与式系统科学和社区- 2) 选择和调整干预措施的参与方法；2) 肺癌预防和风险降低干预措施；3) 干预措施开发和实施科学。汤普森的职业发展计划包括大量的指导、教学培训和体验式培训在英国马基癌症中心 (MCC) 学习，并获得英国健康公平中心的额外支持她将直接接受转化 (CHET) 和英国临床与转化科学中心 (CCTS) 的资助。 MCC 社区影响办公室主任 Pamela Hull 博士（主要导师）和 CHET 主任的指导 Nancy Schoenberg 博士（联合主要导师）以及 Ellen Hahn 博士（导师）在肺科领域的额外指导癌症预防和降低风险，Teresa Waters 博士（导师）评估干预效果和健康经济学，以及 Jessica Burke 博士（匹兹堡大学导师）在系统科学和总体而言，K99/R00 应用的目标将推进肺癌干预。通过为未来 R01 提交提供证据并支持 Thompson 博士的研究，为阿巴拉契亚女性开展研究作为独立科学家接受培训，实施干预措施以改善阿巴拉契亚妇女的健康。