Global Cardiometabolic Disease Training

全球心脏代谢疾病培训

• 批准号: 10270365
• 负责人: Linda S Adair
• 金额: $ 21.78万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270365
• 关键词: Cardiometabolic Disease; Training

Abstract We propose to renew our global cardiometabolic disease (GCMD) predoctoral training program. This cross- disciplinary nutrition-focused program provides specialized training to develop a cadre of researchers who can bridge basic, translational, and population science to reduce the growing burden and disparities in GCMD. There is critical need to reduce this burden in low- and middle-income countries that are disproportionately affected and where more specialized skills and global leadership are most needed. The training program is administered in the Department of Nutrition in the Gillings School of Global Public Health and in the UNC School of Medicine, a logical and well-placed home for a GCMD training grant. Nutrition science integrates “omics” (e.g., genomics, proteomics, metabolomics), behavioral, and population approaches and data to understand complex pathobiological processes and underlying causes of population health differences in GCMD, thus providing a strong platform for training translational global researchers in this field. Our program is co-directed by two senior faculty with strong mentoring records and extensive global experience and leadership in GCMD research. The program is guided by an internal training committee and an external advisory board. Our 22 UNC training faculty are scientists with substantial research support, excellent publication records across a wide range of disciplines, and strong mentoring experience. We request support for 5 predoctoral trainees per year. Trainees complete the PhD in nutrition and GCMD program-specific requirements, including specialized courses in global health and cardiovascular disease and options for in-depth training in (1) specialized methods important for GCMD, (2) translational medicine, or (3) implementation science. All trainees participate in a seminar led by the program directors, mentored research practicums, training in the responsible conduct of research, and mentoring for professional development, including submitting an NIH-style predoctoral and/or F award or similar application for extramural funding, and unique global internships with 15 global mentors who are exceptional CMD researchers working at 13 top universities or research centers in 11 countries. Our training program stands out because of its: (1) focus on nutrition, a major etiologic factor in the global disease burden; (2) life course approach to addressing GCMD; (3) interdisciplinary focus on causes ranging from cellular and molecular to whole organism and accounting for underlying social, economic, political, and environmental determinants; (4) emphasis on integration and translation of basic knowledge and discoveries from nutrition biochemistry, physiology, genetics, and epidemiology, to behavioral and environmental approaches and policies; and (5) outstanding faculty mentors who serve as role models for excellence in GCMD research and leaders working with countries to implement and evaluate large-scale regulatory efforts to prevent cardiometabolic disease. The program is training future leaders in GCMD research.

抽象的 我们建议更新我们的全球心脏代谢疾病（GCMD）博士前培训计划。 以学科营养为重点的计划提供专门培训，以培养一支研究人员队伍 可以弥合基础科学、转化科学和人口科学，以减少日益增长的负担和差距 GCMD 迫切需要减轻低收入和中等收入国家的这一负担。 受影响尤为严重，而且最需要更专业的技能和全球领导力。 培训计划由吉林斯全球公共卫生学院营养系管理 北卡罗来纳大学医学院是 GCMD 营养培训补助金的理想之家。 科学整合了“组学”（例如基因组学、蛋白质组学、代谢组学）、行为学和人口学 了解复杂的病理生物学过程和人口根本原因的方法和数据 GCMD 的健康差异，从而为培训全球转化研究人员提供了一个强大的平台 我们的项目由两位具有丰富指导经验和广泛经验的资深教师共同指导。 GCMD 研究的全球经验和领导力该计划以内部培训为指导。 我们的 22 名 UNC 培训教师都是具有丰富经验的科学家。 研究支持、跨学科的优秀发表记录以及强有力的指导 我们请求每年支持 5 名博士前学员完成营养学博士学位。 和 GCMD 计划的具体要求，包括全球健康和 心血管疾病和深入培训的选择 (1) 对 GCMD 重要的专业方法，(2) 转化医学，或 (3) 实施科学 所有学员参加由该项目主导的研讨会。 主任、指导研究实践、负责任的研究行为培训以及指导 专业发展，包括提交 NIH 式的博士前和/或 F 奖或类似奖项 申请校外资助，并与 15 位杰出的全球导师一起进行独特的全球实习 CMD 研究人员在 11 个国家的 13 所顶尖大学或研究中心工作。 之所以脱颖而出，是因为：(1) 关注营养，这是全球疾病负担的一个主要病因；(2) 生活； (3) 跨学科关注从细胞和 从分子到整个有机体以及对潜在社会、经济、政治和环境的解释 (4)重视营养学基础知识和发现的整合与转化 生物化学、生理学、遗传学和流行病学，行为和环境方法以及 (5) 杰出的导师，他们是 GCMD 研究卓越的榜样 和各国工作领导人实施和评估大规模监管努力，以预防 该项目正在培训 GCMD 研究的未来领导者。