A 5minute motion-corrected pediatric brain MRI protocol

5 分钟运动校正儿童脑部 MRI 方案

• 批准号: 9112219
• 负责人: Michael E Moseley
• 金额: $ 19.75万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9112219
• 关键词: Acute Brain Injuries; Algorithms; Anxiety; Attenuated; Base of the Brain; Brain; Brain Neoplasms; Brain imaging; Caring; Cerebrospinal Fluid; Child; Childhood; Clinical; Confined Spaces; Coupling; Development; Diagnosis; Diagnostic; Diagnostic tests; Diffusion Magnetic Resonance Imaging; Disadvantaged; Early treatment; Echo-Planar Imaging; Environment; Failure; Family; General Anesthesia; Goals; Gold; Grant; Health Care Costs; Healthcare; Hour; Image; Imaging Techniques; Immune; Institution; Lead; Liquid substance; Magnetic Resonance Imaging; Maps; Methods; Morphologic artifacts; Motion; Outcome; Patients; Plague; Population; Predisposition; Process; Protocols documentation; Recovery; Research; Resolution; Risk; Safety; Scanning; Sedation procedure; Speed; T2 weighted imaging; Testing; Time; Weight; Work; base; compliance behavior; cost; imaging modality; improved; magnetic field; neonate; novel; patient safety; pediatric patients; prototype; public health relevance; reconstruction; volunteer

 DESCRIPTION (provided by applicant): The main disadvantage of MRI is its long scan time, taking up to one hour at our institution. For children, MRI can be particularly frightening because of long scan times within a noisy and confined space that can increase anxiety and risk of motion artifacts in the acquired images. In cases of excessive motion, MRI sequences are often repeated, further increasing scan time, or requiring patient revisit to the MRI suite. Alternativel, general anesthesia (GA) is used - which reduces the overall patient comfort, safety, throughput, and adding to the cost of care. As a result of these major issues, there is an immediate need for a fast MRI protocol that parallels the diagnostic capacity of the standard MRI. The methods here will overcome a set of well-known problems with the use of fast imaging using Echo Planar Imaging (EPI) through the use of a family of `short axis EPI' motion-correctable MRI methods. The 5minute exam we will develop based on these methods will reduce the scan failure rate through a rapid non-sedated brain exam with high diagnostic quality - potentially leading to detecting abnormalities in patients who otherwise cannot be reliably scanned with MRI. By obviating the need for patient sedation, improving patient comfort and reducing the scan time by up to 35min per patient, we propose to dramatically increase patient throughput, comfort, reduce scan failure rate, and the cost of healthcare.

 描述（由适用提供）：MRI的主要灾难是其长时间的扫描时间，在我们的机构中​​最多需要一个小时。对于孩子来说，MRI可能特别令人恐惧，因为 在噪音和狭窄空间内长期扫描时间，可以增加获得图像中运动伪影的焦虑和风险。在运动过多的情况下，经常重复MRI序列，进一步增加扫描时间或要求患者重新访问MRI套件。使用替代性麻醉（GA） - 降低了患者的整体舒适性，安全性，吞吐量并增加了护理费用。由于这些主要问题，即时需要快速的MRI协议，与标准MRI的诊断能力相同。这里的方法将通过使用“短轴EPI”运动可校正MRI方法的家族使用回声平面成像（EPI）来克服一组知名问题。我们将根据这些方法进行的5分钟考试将通过快速的非诊断脑检查降低扫描失败率，并具有很高的诊断质量 - 可能导致检测到其他MRI无法可靠地扫描的患者的异常。通过消除对患者镇静的需求，改善患者舒适度并减少每位患者最多35分钟的扫描时间，我们建议大幅提高患者吞吐量，舒适度，降低扫描失败率以及医疗保健成本。