NONGAUSSIAN DIFFUSION BEHAVIOR IN BRAIN

大脑中的非高斯扩散行为

• 批准号: 7358744
• 负责人: Michael E Moseley
• 金额: $ 2.49万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358744
• 关键词: NONGAUSSIAN; DIFFUSION; BEHAVIOR; BRAIN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research is to develop models of non-random diffusion in the human body using diffusion tensor imaging (DTI) for the investigators and collaborators on the P41 RR09784 ?Center for Advanced MR Technology at Stanford? effort. Studies using high levels of diffusion sensitization (b 2000 sec/mm2) appear to indicate that the ADC has separate components, producing a non-monoexponential signal decay with diffusion sensitization at the higher b values. Studies of proton diffusion at high b values, however, may provide tissue contrast from a ?slower? ADC component (of the biexponential model) that may more relevant to the expanding intracellular compartment (also seen as cytotoxic edema), since it may be in exchange with the ?fast? ADC water population. Upon modeling this, we find that this occurs mostly in white matter where fibers may be crossing, producing non-random diffusion. A faster ADC component dominates at low b values, while at higher b-values, a second, slower ADC component becomes apparent. It is striking to note the large differences and the lack of any observable slow FA tissue contrast. We have finished all anticipated work on this effort and have submitted these results as a published abstract supporting our models.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的目的是使用扩散张量成像（DTI）为P41 RR09784？斯坦福大学高级MR Technology中心的研究人员和合作者开发人体非随机扩散模型吗？努力。使用高水平的扩散敏化（B 2000 sec/mm2）的研究似乎表明ADC具有单独的成分，在较高的B值下产生了具有扩散敏化的非单声指数信号衰减。但是，对高​​B值的质子扩散的研究可能会从A较慢的组织对比度？ ADC分量（Biexpential模型的）可能与扩展的细胞内室（也被视为细胞毒性水肿）更相关，因为它可能与？快速交换？ ADC水数量。对此进行建模后，我们发现这主要发生在纤维可能越过的白质中，从而产生非随机扩散。更快的ADC分量在低B值下占主导地位，而在较高的B值下，第二个较慢的ADC组件变得显而易见。注意到巨大的差异以及缺乏任何可观察到的慢速FA组织对比度。我们已经完成了这项工作的所有预期工作，并将这些结果作为支持我们的模型的已发表摘要。